Erste Erfahrungen mit medizinischem Honig in der Wundbehandlung im Kopf-Hals-Bereich

Knipping, S.; Grunewald, Barbara; Hirt, R.

doi:10.1007/s00106-012-2503-4

Cited by 4 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To preserve the effectiveness of antibiotics and to treat infections caused by resistant bacteria, alternative approaches are required that can be used instead of antibiotics or after they have failed. One possible alternative currently being investigated for some applications is honey (Descottes, 2009; Knipping et al, 2012; Vandamme et al, 2013). Produced by the honey bee, Apis mellifera , honey has a long history in human medicine (Breasted, 1948) and has remained a staple treatment in traditional medicine.…”

Section: Introductionmentioning

confidence: 99%

Evolution of honey resistance in experimental populations of bacteria depends on the type of honey and has no major side effects for antibiotic susceptibility

Bischofberger

Pfrunder‐Cardozo

Baumgärtner

et al. 2021

Evolutionary Applications

View full text Add to dashboard Cite

With rising antibiotic resistance, alternative treatments for communicable diseases are increasingly relevant. One possible alternative for some types of infections is honey, used in wound care since before 2000 BCE and more recently in licensed, medical‐grade products. However, it is unclear whether medical application of honey results in the evolution of bacterial honey resistance and whether this has collateral effects on other bacterial traits such as antibiotic resistance. Here, we used single‐step screening assays and serial transfer at increasing concentrations to isolate honey‐resistant mutants of Escherichia coli. We only detected bacteria with consistently increased resistance to the honey they evolved in for two of the four tested honey products, and the observed increases were small (maximum twofold increase in IC90). Genomic sequencing and experiments with single‐gene knockouts showed a key mechanism by which bacteria increased their honey resistance was by mutating genes involved in detoxifying methylglyoxal, which contributes to the antibacterial activity of Leptospermum honeys. Crucially, we found no evidence that honey adaptation conferred cross‐resistance or collateral sensitivity against nine antibiotics from six different classes. These results reveal constraints on bacterial adaptation to different types of honey, improving our ability to predict downstream consequences of wider honey application in medicine.

show abstract

Section: Introductionmentioning

confidence: 99%

Evolution of honey resistance in experimental populations of bacteria depends on the type of honey and has no major side effects for antibiotic susceptibility

Bischofberger

Pfrunder‐Cardozo

Baumgärtner

et al. 2021

Evolutionary Applications

View full text Add to dashboard Cite

show abstract

“…To preserve the effectiveness of antibiotics and to treat infections caused by resistant bacteria, alternative approaches are required that can be used instead of antibiotics or after they have failed. One possible alternative currently being investigated for some applications is honey (Descottes, 2009;Knipping et al, 2012;Vandamme et al, 2013). Produced by the honey bee, Apis mellifera, honey has a long history in human medicine (Breasted, 1948) and has remained a staple treatment in traditional medicine.…”

Section: Introductionmentioning

confidence: 99%

Evolution of Honey Resistance in Experimental Populations of Bacteria Depends on the Type of Honey, and Has no Major Side Effects for Antibiotic Susceptibility

Bischofberger

Pfrunder‐Cardozo

Baumgärtner

et al. 2020

Preprint

View full text Add to dashboard Cite

With rising antibiotic resistance, alternative treatments for communicable diseases are increasingly relevant. One possible alternative for some types of infections is honey, used in wound care since before 2000 BCE and more recently in licensed, medical-grade products. However, it is unclear whether medical application of honey results in the evolution of bacterial honey resistance, and whether this has collateral effects on other bacterial traits such as antibiotic resistance. Here, we used single-step screening assays and serial transfer at increasing concentrations to isolate honey-resistant mutants of Escherichia coli. We only detected bacteria with consistently increased resistance to the honey they evolved in with two of the four tested honey products, and the observed increases were small (maximum two-fold increase in IC90). Genomic sequencing and experiments with single-gene knockouts showed a key mechanism by which bacteria increased their honey resistance was by mutating genes involved in detoxifying methylglyoxal, which contributes to the antibacterial activity of Leptospermum honeys. Crucially, we found no evidence that honey adaptation conferred cross-resistance or collateral sensitivity against nine antibiotics from six different classes. These results reveal constraints on bacterial adaptation to different types of honey, improving our ability to predict downstream consequences of wider honey application in medicine.

show abstract

“…Hierzu gehören Verbrennungen, diabetische Ulzera aber auch die Psoriasis und chronische Wunden bei Tumorpatienten[ 25 ] . In einer randomisiert angelegten klinischen Studie konnte beispielsweise gezeigt werden, dass es bei einer vergleichbar hohen MRSA-Keimbesiedlung durch die prophylaktische postoperative Anwendung von medizinischem Honig auf den Operationswunden es zu einer signifi kanten Reduktion der stationären Aufenthaltsdauer gekommen ist[ 27 ] .…”

unclassified

Die Behandlung chronischer Wunden im Kopf-Hals-Bereich nach Radiatio mit medizinischem Honig

et al. 2014

View full text Add to dashboard Cite

show abstract

Erste Erfahrungen mit medizinischem Honig in der Wundbehandlung im Kopf-Hals-Bereich

Abstract: In the treatment of poorly healing and infected wounds within the head and neck area, medical honey can be used successfully without problems as an effective alternative to conventional treatment options.

Cited by 4 publications

References 15 publications

Evolution of honey resistance in experimental populations of bacteria depends on the type of honey and has no major side effects for antibiotic susceptibility

Evolution of honey resistance in experimental populations of bacteria depends on the type of honey and has no major side effects for antibiotic susceptibility

Evolution of Honey Resistance in Experimental Populations of Bacteria Depends on the Type of Honey, and Has no Major Side Effects for Antibiotic Susceptibility

Die Behandlung chronischer Wunden im Kopf-Hals-Bereich nach Radiatio mit medizinischem Honig

Contact Info

Product

Resources

About