Erythema elevatum diutinum as a paraneoplastic syndrome in a patient with pulmonary lymphoepithelioma-like carcinoma

Liu, Ta‐Chiang; Chen, I-Shu; Lin, Ting Wei; Lee, J. Yu-Yun; Kirn, David H.; Tsao, Chao-Jung

doi:10.1016/j.lungcan.2008.05.006

Cited by 9 publications

(6 citation statements)

References 11 publications

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“…Therefore, it is rather difficult to draw a robust conclusion. Two of the three lymphoma cases, non‐Hodgkin's lymphoma and pulmonary lymphoepithelioma‐like carcinoma, exhibited parallel EED lesions that resolved after successful chemotherapy of underlying lymphoma . This suggests EED's role as that of a paraneoplastic syndrome.…”

Section: Discussionmentioning

confidence: 87%

Erythema elevatum diutinum: a case report and review of literature

Doktor¹,

Hadi

Phelps

et al. 2018

Int J Dermatology

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Erythema elevatum diutinum (EED) is a rare cutaneous leukocytoclastic vasculitis thought to be related to increased levels of circulating antibodies. It has been shown to be associated with HIV infection, tuberculosis, as well as various autoimmune diseases. A retrospective review of all cases of EED indexed in PubMed between 1990 and 2014 was performed. Inclusion criteria for articles was availability of full text in English and a biopsy-confirmed diagnosis of EED. All other articles were excluded. Cases were stratified by age and anatomic location of the lesions. Treatment response was coded as "complete," "partial," and "none." A total of 133 cases of EED with 381 lesions detailed in case reports and case series were included. Twenty-one cases were associated with HIV. Of 47 patients with reported paraproteinemias, IgA paraproteinemia was found in 57.45%, IgG paraproteinemia in 29.8%, IgM paraproteinemia in 10.6%, and IgD paraproteinemia in 2.1% of cases. Of 40 (30.1%) patients with reported comorbid autoimmune disease, rheumatoid arthritis was associated with 10 cases. Cancer was found to be associated with 9.77% of cases. Seventy-five patients were treated with dapsone, with 36 (48%) achieving complete treatment response, 24 (32%) achieving partial response, and seven (9.3%) achieving no response. Keeping the clinical associations of EED in mind, especially malignancy, is critical in management of the disease. More structured studies need to take place in order to fully define the mechanisms and strength of these associations.

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Section: Discussionmentioning

confidence: 87%

Erythema elevatum diutinum: a case report and review of literature

Doktor¹,

Hadi

Phelps

et al. 2018

Int J Dermatology

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“…Many case reports have also documented improvement in EED with treatment of underlying conditions including inflammatory diseases, blood cell dyscrasias, or malignancies. [7][8][9][10][11][12] Finally, successful surgical excision of persistent lesions has been documented in multiple cases, which presumably are those of toxin hyaline. 13,14 EED often follows a prolonged course with periods of relative exacerbation, and persistence of disease for greater than 30 years has been described.…”

Section: Discussionmentioning

confidence: 99%

Persistent Papules in Erythema Elevatum Diutinum Treated With Dapsone: Answer

Olvera,

Hurley,

Jeter

et al. 2024

The American Journal of Dermatopathology

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“…The skin lesions didn’t fade at all after topical steroid treatment. Combination of chemotherapy and radiotherapy achieved over 3 years of disease-free survival and marked relief of EED [ 44 ]. We concluded some data of the two cases in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

Polymyositis as a paraneoplastic syndrome of a patient with primary pulmonary lymphoepithelioma-like carcinoma: a case report and literature review

Lei

Liu

Wan

et al. 2022

J Cardiothorac Surg

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Background Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of non-small cell lung cancer, which mostly occurred in non-smoking Asian populations. The prognosis of this tumor is better than other lung cancers. Polymyositis, a kind of idiopathic inflammatory myopathies, may negatively affect the prognosis of patients with lung cancer as a paraneoplastic syndrome (PNPS). LELC is seldomly accompanied by PNPS, thus the treatment strategy and prognosis should be discussed. Case presentation We report a 49-year-old female patient who was hospitalized for “symmetric limb weakness and pain for more than 2 months”. Glucocorticoid-based anti-inflammatory therapy had been performed for over 3 weeks before the patient was hospitalized, however, in vain. The result of serum autoimmune antibody showed Anti-nRNP/Sm ( +). The serum level of myoglobin, lactate dehydrogenase and creatine kinase elevated significantly. An electromyogram revealed peripheral nerves injury and myogenic damages. Imaging showed a mass in the posterior basal segment of the left lung. A percutaneous transthoracic needle biopsy was performed and the pathological result was LELC. The patient was diagnosed with pulmonary LELC accompanied by polymyositis. Positron emission tomography-computed tomography (PET-CT) showed only ipsilateral hilar and mediastinal lymph nodes metastasis. Video-assisted thoracoscopic left lower lobectomy and systematic mediastinal lymphadenectomy were performed. The postoperative pathological stage was T2N2M0, IIIA (UICC 8th), and the patient received adjuvant chemotherapy and subsequent radiotherapy. The patient was followed up for 5 months with no recurrence of tumor and the limb weakness and pain were relieved apparently after the successful comprehensive treatment of her primary tumor. Conclusion Pulmonary LELC is a rare subtype of non-small cell lung cancer seldomly accompanied by PNPS. Though polymyositis is associated with lung cancer, it is easy to ignore this relationship when a patient is diagnosed with LELC in the clinic. Surgery based comprehensive treatment of primary tumor can lead to a prospective prognosis in pulmonary LELC patients with PNPS. And successful treatment of pulmonary LELC can also improve symptoms of PNPS.

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Erythema elevatum diutinum as a paraneoplastic syndrome in a patient with pulmonary lymphoepithelioma-like carcinoma

Cited by 9 publications

References 11 publications

Erythema elevatum diutinum: a case report and review of literature

Erythema elevatum diutinum: a case report and review of literature

Persistent Papules in Erythema Elevatum Diutinum Treated With Dapsone: Answer

Polymyositis as a paraneoplastic syndrome of a patient with primary pulmonary lymphoepithelioma-like carcinoma: a case report and literature review

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