Erythrocyte Cation Content, Globin Chain Synthesis and Glucose Metabolism in Dysmyelopoietic Syndromes

Cetto, Gian Luigi; Vettore, L.; Matteis, M. C. De; Piga, Andrea; Verona, Giuseppe

doi:10.1159/000206963

Cited by 13 publications

(3 citation statements)

References 13 publications

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“…The association of glucose and MDS requires further investigation. It is worth mentioning that impaired glucose metabolism in red blood cells, 45 and involvement of glucose metabolism in the erythropoiesis in MDS patients, has already been reported. [46][47][48] MCV in diabetes has been investigated but no definitive conclusions made.…”

Section: Discussionmentioning

confidence: 93%

A predictive algorithm using clinical and laboratory parameters may assist in ruling out and in diagnosing MDS

et al. 2021

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We present a noninvasive Web-based app to help exclude or diagnose myelodysplastic syndrome (MDS), a bone marrow (BM) disorder with cytopenias and leukemic risk, diagnosed by BM examination. A sample of 502 MDS patients from the European MDS (EUMDS) registry (n > 2600) was combined with 502 controls (all BM proven). Gradient-boosted models (GBMs) were used to predict/exclude MDS using demographic, clinical, and laboratory variables. Area under the receiver operating characteristic curve (AUC), sensitivity, and specificity were used to evaluate the models, and performance was validated using 100 times fivefold cross-validation. Model stability was assessed by repeating its fit using different randomly chosen groups of 502 EUMDS cases. AUC was 0.96 (95% confidence interval, 0.95-0.97). MDS is predicted/excluded accurately in 86% of patients with unexplained anemia. A GBM score (range, 0-1) of less than 0.68 (GBM < 0.68) resulted in a negative predictive value of 0.94, that is, MDS was excluded. GBM ≥ 0.82 provided a positive predictive value of 0.88, that is, MDS. The diagnosis of the remaining patients (0.68 ≤ GBM < 0.82) is indeterminate. The discriminating variables: age, sex, hemoglobin, white blood cells, platelets, mean corpuscular volume, neutrophils, monocytes, glucose, and creatinine. A Web-based app was developed; physicians could use it to exclude or predict MDS noninvasively in most patients without a BM examination. Future work will add peripheral blood cytogenetics/genetics, EUMDS-based prospective validation, and prognostication.

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Section: Discussionmentioning

confidence: 93%

A predictive algorithm using clinical and laboratory parameters may assist in ruling out and in diagnosing MDS

et al. 2021

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“…The addition of exogenous haem (0 4 mmol/l) to the incubation mixture in reticulocytes in 16 cases with MDS (table 1) resulted in a significant (p < 0 01) increase in the mean value of the a:fl ratio from 0-91 (0 48) (sample A) to 11 (0 44) (sample B). The observed positive haem effect was more evident in group I compared with groups II and III (p = 0 01) and was not associated with serum iron concentration or with bone marrow iron storage.…”

Section: Effect Of Haemin On the Ocf: Ratiomentioning

confidence: 98%

Globin chain synthesis in myelodysplastic syndromes.

et al. 1991

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Globin chain synthesis was studied in the reticulocytes of 30 patients with various myelodysplastic syndromes (MDS) to determine the ca:f globin chain synthetic ratio and its probable prognostic value.The mean (SD) value of the total az:# ratio was 0l82 (0 45) ranging from 0 05 to 1-73. The same ratio in 10 normal controls was 1 01 (0 04). This difference was significant. Furthermore, the %:P ratios were lower than normal in 14 patients (acthalassaemia-like) (group I), almost within normal limits in 11 (group II), and higher than normal in five (fithalassaemia-like) (group III). In each group almost all the FAB subtypes were represented. The addition of exogenous haem in several of the test samples resulted in a slight to pronounced increase in the m:f ratios, particularly in group I. In 92% of the high risk cases (refractory anaemia with excess blasts (RAEB), chronic myelomonocytic leukaemia (CMML)) or 87-5% of patients who finally developed acute non-lyphoid leukaemia (ANLL) low or normal a:f ratios were found. No significant correlation was noticed between a:f ratios and various haematological variables or survival.It is concluded that in MDS the z:f ratio varied enormously across the entire population of patients, as well as within each FAB subtype, thereby restricting its prognostic value. Although haem deficiency may be implicated in some cases of MDS, why this should be remains unclear.

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“…There may be a variety of metabolic abnormalities (Valentine et al, 1973;Cetto et al, 1982), the reappearance of haemoglobin F (Richard et al, 1979), acquired haemoglobin H (Boehme et al, 1978) and changes in membrane antigens (Levine et al, 1984). These changes are associated with gross dyserythropoietic appearances in the bone marrow with both nuclear and cytoplasmic abnormalities.…”

Section: Clinical Datamentioning

confidence: 99%

Human preleukaemia: do we have a model?

Jacobs¹

1987

Br J Cancer

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Erythrocyte Cation Content, Globin Chain Synthesis and Glucose Metabolism in Dysmyelopoietic Syndromes

Cited by 13 publications

References 13 publications

A predictive algorithm using clinical and laboratory parameters may assist in ruling out and in diagnosing MDS

A predictive algorithm using clinical and laboratory parameters may assist in ruling out and in diagnosing MDS

Globin chain synthesis in myelodysplastic syndromes.

Human preleukaemia: do we have a model?

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