Erythrocyte cholinesterase titers in hematologic disease states

Sabine, Jean C.

doi:10.1016/0002-9343(59)90063-4

Cited by 31 publications

(9 citation statements)

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“…High activity was found in the reticulocyte-rich and low activity in the reticulocytepoor fractions. Sabine [87,88] obtained similar results by applying the same procedure to blood from patients with various hematologic disorders. By transfusing erythrocytes of group O into A-type normal recipients, and then isolating the donor's cells, Allison and Burn [2] demonstrated that the loss in acetylcholinesterase activity with time was compatible with an exponential decay curve with the assumption that in normal subjects cells of all ages are present in equal quantities.…”

Section: Acetylcholinesterase In the Erythrocytementioning

confidence: 73%

A Review: Human Erythrocyte Acetylcholinesterase

Herz

Kaplan

1973

Pediatr Res

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Section: Acetylcholinesterase In the Erythrocytementioning

confidence: 73%

A Review: Human Erythrocyte Acetylcholinesterase

Herz

Kaplan

1973

Pediatr Res

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“…Yritchard (1949) found that repeated exsanguination of rats resulted in a 30 per cent reticulocytosis and an increase in the red-cell cholinesterase of 50-70 per cent. The relation of this enzyme to human blood disorders was also studied by Sabine (1959). Sass, Vorsanger and Spear (1964, who also investigated a number of enzymes as possible parameters of red-cell age, concluded that glutamic-oxaloacetic transaminase was the most sensitive for this purpose, the activity of this enzyme in young cells being two-to three-fold greater than in old cells.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Age on the Creatine in Red Cells

Griffiths

Fitzpatrick

1967

Br J Haematol

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SUMMARY The creatine in packed red cells was estimated by the diacetyl‐i‐naphthol technique. The error due to the presence of other guanidino compounds in the cells was found to be small. The mean value for creatine in the packed red cells of normal females was found to be 5.6 (S.D. ± 1.3) mg. per 100 ml., and in normal males 4.4 (S.D. ± 1.5) mg. per 100 ml. The sex difference is statistically significant. When red cells were segregated according to age by centrifugation the young red cells contained more creatine than the old cells. The creatine in the mixed population of red cells of patients under treatment for anaemia in whom there was increased erythropoiesis was greatly elevated; values as high as 50 mg. per 100 ml. were observed. With a decline in marrow activity and reticulocytosis there was a persistence of the high red‐cell creatine for a long time, suggesting that the loss of creatine from the cells with age is a gradual process. It is concluded that the level of creatine in the circulating red cells is a sensitive parameter of the mean age of the population.

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“…The finding of normal GSH stability in these two children in the 'S' Family does not lead to any conclusion about the 'M' Family, one of whom had chronic haemolytic disease. A * The relationship between RBC ChE and erythropoietic function and the results in haemolytic disease were reviewed recently (Sabine, 1959). Recent observations have shown that patients with haernolytic crisis associated with RBC G6PD deficiency have high RBC ChE as do persons with erythropoietic response to other types of haemolytic disease.…”

Section: Discussionmentioning

confidence: 99%