Erythrocyte deformability profile evaluated by laser diffractometry in patients with multiple myeloma: Re-examination of our cases

Caimi, Gregorio; Presti, Rosalia Lo; Mancuso, Salvatrice; Siragusa, Sergio; Carlisi, Melania

doi:10.1016/j.mvr.2022.104473

Cited by 6 publications

(6 citation statements)

References 56 publications

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“…Indicating the heterogeneity of the volume of erythrocytes, RDW is a simple and immediately inflammatory marker and it reflects the increase of some cytokines, such as IL-6 and tumor necrosis factor-alpha (TNF-alpha), but also of hepcidin in the blood [ 42 , 43 ]. It is possible that the increase in this predictor may affect the erythrocyte deformability of MM patients, also considering that in some of our previous research [ 18 , 19 , 20 , 21 ], this hemorheological determinant was reduced compared with the control group. In this regard, in a cohort of 298 normal adults, some authors found a negative correlation between RDW and erythrocyte deformability, and only when the RDW value exceeded 14% was the reduction of this hemorheological determinant highlighted [ 44 ].…”

Section: Discussionmentioning

confidence: 78%

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Calculated Whole Blood Viscosity and Albumin/Fibrinogen Ratio in Patients with a New Diagnosis of Multiple Myeloma: Relationships with Some Prognostic Predictors

et al. 2023

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Background: In this single center study, we retrospectively evaluated the calculated hemorheological profile in patients with a new diagnosis of multiple myeloma, with the aim to evaluate possible relationships with some prognostic predictors, such as ISS, albumin levels, beta2-microglobulin, red cell distribution width, and bone marrow plasma cell infiltration. Methods: In a cohort of 190 patients, we examined the calculated blood viscosity using the de Simone formula, and the albumin/fibrinogen ratio as a surrogate of erythrocyte aggregation, and then we related these parameters to prognostic factors, using the Kruskal–Wallis and the Mann–Whitney tests, respectively. Results: From our analysis, it emerged that the evaluated hemorheological pattern differed in the three isotypes of multiple myeloma, and the whole blood viscosity was higher in IgA and IgG isotypes with respect to the light chain multiple myeloma (p < 0.001). Moreover, we observed that, as the ISS stage progressed, the albumin/fibrinogen ratio was reduced, and the same hemorheological trend was traced in subgroups with lower albumin levels, higher beta2-microglobulin and red cell distribution width RDW values, and in the presence of a greater bone marrow plasma cell infiltrate. Conclusions: Through the changes in blood viscosity in relation to different prognostic factors, this analysis might underline the role of the hemorheological pattern in multiple myeloma.

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Section: Discussionmentioning

confidence: 78%

“…Finally, in the MM setting, the hemorheological pattern can play a significant role, especially in terms of whole blood viscosity (WBV) and erythrocytes deformability and aggregation [ 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Calculated Whole Blood Viscosity and Albumin/Fibrinogen Ratio in Patients with a New Diagnosis of Multiple Myeloma: Relationships with Some Prognostic Predictors

et al. 2023

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“…In another study of Caimi et al compared the results of EI in blood samples obtained from 29 MM patients and found out that its values were significantly lower compared with healthy subjects, especially in lower values of shear stress and were not depending on stage of the disease. However, as the study included only 5 patients in remission stage, it is difficult to compare its results with those we received 27 .…”

Section: Discussionmentioning

confidence: 99%

Rheological properties of blood in multiple myeloma patients

Ptaszek,

Podsiadło,

Jandziś

et al. 2024

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Multiple myeloma (MM) is considered to be one of the hematological malignancies formed by excessive and abnormal proliferation of plasmocytes. Among other parameters, several blood tests are used to diagnose multiple myeloma. The hemorheological profile in multiple myeloma is not widely studied. Hemorheology includes the study of measuring the deformability and aggregation of erythrocytes, blood viscosity, and sedimentation rate. The degree of deformability of blood cells is necessary to maintain proper vital functions. Proper deformability of red blood cells ensures proper blood circulation, tissue oxidation and carbon dioxide uptake. The aim of the study was to compare morphology and blood rheology parameters in patients with MM and healthy individuals. The study included 33 patients with MM, and 33 healthy subjects of the same age. The hematological blood parameters were evaluated using ABX MICROS 60 hematology analyzer. The LORCA Analyzer to study erythrocyte aggregation and deformability. Patients with MM had lower red blood cells count (RBC) (9.11%) (p < 0.001) and half time of total aggregation (T1/2) (94.29%) (p < 0.001) values and higher mean corpuscular volume (MCV) (5.50%) (p < 0.001), aggregation index (AI) (68.60%) (p < 0.001), total extent of aggregation (AMP) (87.92%) (p < 0.001) values than the healthy control group. Aggregation in patients with MM is different compared to healthy individuals. It was observed that the percentage of cell aggregation is almost 50% higher than in the control group. The study of morphology, aggregation and deformability of erythrocytes in patients with suspected MM may be helpful in making clinical decisions.

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“…However, while in healthy subjects and in patients with hematological neoplasms the correlation between these two parameters was significantly negative, in other clinical disorders the same correlation was positive and not easy to interpret. In our study population, represented by 190 patients with newly diagnosed MM, we do not have any data on erythrocyte deformability, but previously, although in a limited number of MM patients, we have highlighted a reduction of erythrocyte deformability with diffractometric technique 56 – 60 . So far, we have charged this alteration to anomalies of the dynamic properties of the membrane, and particularly, to its lipid composition and to the behaviour of phosphatidylserine that tend to move from the inner to the outer leaflet.…”

Section: Discussionmentioning

confidence: 99%

Changes in RDW according to prognostic predictors in newly diagnosed multiple myeloma

Carlisi,

Presti,

Plano

et al. 2024

Sci Rep

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RDW is an erythrocyte index that increase in multiple myeloma, in which it appears to have an important role in predicting outcome. For this reason, we performed a retrospective analysis to evaluate the relationships of RDW with some important prognostic predictors. Specifically, in a cohort of 190 newly diagnosed multiple myeloma patients, we have examined the behaviour of RDW and its trend in relation to the ISS stage and other prognostic factors, such as albumin, beta-2 microglobulin, LDH and bone marrow plasma cell infiltration. We performed the analysis in the entire cohort of patients and in the three different disease isotypes (Light chain, IgA, and IgG multiple myeloma). The evaluation of RDW in the different isotypes was made with the Kruskal–Wallis test, integrated by the Dunn test. The comparison between the subgroups allocated above and below the median value of each prognostic factor, was made with the Mann–Whitney test. From our analysis, we observed that RDW is higher in the IgA multiple myeloma, and it increases significantly from ISS I to III. Moreover, RDW increases in the presence of lower albumin values, higher levels of beta2-microglobulin and LDH and in the presence of a greater bone marrow plasma cell infiltrate.

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Erythrocyte deformability profile evaluated by laser diffractometry in patients with multiple myeloma: Re-examination of our cases

Cited by 6 publications

References 56 publications

Calculated Whole Blood Viscosity and Albumin/Fibrinogen Ratio in Patients with a New Diagnosis of Multiple Myeloma: Relationships with Some Prognostic Predictors

Calculated Whole Blood Viscosity and Albumin/Fibrinogen Ratio in Patients with a New Diagnosis of Multiple Myeloma: Relationships with Some Prognostic Predictors

Rheological properties of blood in multiple myeloma patients

Changes in RDW according to prognostic predictors in newly diagnosed multiple myeloma

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