Erythrocyte-erythrocyte aggregation dynamics under shear flow

Abbasi, Mehdi; Farutin, Alexander; Ez‐Zahraouy, H.; Benyoussef, A.; Misbah, Chaouqi

doi:10.1103/physrevfluids.6.023602

Cited by 20 publications

(10 citation statements)

References 45 publications

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“…We also observe an adhesive effect between the two JP vesicles that is set up by the hydrophobic attraction (figure 10c). Similar dynamics have been observed between a pair of adhering vesicles in a shear flow (Quaife et al 2019;Abbasi et al 2021). This adhesive behaviour is absent when two JP vesicles are well-separated.…”

Section: Stretching and Permeabilitysupporting

confidence: 74%

Two-dimensional hydrodynamics of a Janus particle vesicle

Quaife

Ryham

et al. 2022

J. Fluid Mech.

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We develop a new model, to our knowledge, for the many-body hydrodynamics of amphiphilic Janus particles suspended in a viscous background flow. The Janus particles interact through a hydrophobic attraction potential that leads to self-assembly into bilayer structures. We adopt an efficient integral equation method for solving the screened Laplace equation for hydrophobic attraction and for solving the mobility problem for hydrodynamic interactions. The integral equation formulation accurately captures both interactions for near touched boundaries. Under a linear shear flow, we observe the tank-treading deformation in a two-dimensional vesicle made of Janus particles. The results yield measurements of intermonolayer friction, membrane permeability and, at large shear rates, membrane rupture. The simulation studies include a Janus particle vesicle in both linear and parabolic shear flows, and interactions between two Janus particle vesicles in shear and extensional flows. The hydrodynamics of the Janus particle vesicle is similar to the behaviour of an inextensible, elastic vesicle membrane with permeability.

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Section: Stretching and Permeabilitysupporting

confidence: 74%

Two-dimensional hydrodynamics of a Janus particle vesicle

Quaife

Ryham

et al. 2022

J. Fluid Mech.

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“…This has been recently confirmed by simulations in Ref. [31]. Furthermore, Brust et al [10] have shown that rouleaux induced by fibrinogen and dextran persist even at the microvascular circulation level.…”

Section: Discussionsupporting

confidence: 52%

“…Dupire et al [54] also found a hysteresis with the shear rate in the fluidized regime. The cells transition from tank-treading to tumbling intermittently while decreasing _ c, and the tumbling evolves to rolling, and then the transition to tank-treading occurs via a transient Frisbee-like spinning motion with increasing _ c. The tank-treading motion also plays an important roll in the disaggregation process of doublets [30,31]. However, in our setup we were not able to observe the tank-treading motion, though we do not exclude its contribution as we are in the fluidized regime.…”

Section: Discussionmentioning

confidence: 99%

“…A possible explanation is that most studies were in bulk rheology and the model macromolecules used to induce an attractive force between the RBCs show contradicting evidence [27][28][29]. The studies performed at a cell-to-cell level show that tank-treading is essential in the disaggregation process [30,31] and the minimal drag force during shearing is in the range 0.5-5 pN [6,32]. Thus, in this work, we will study the breakup of aggregates of two RBCs (a doublet) in shear flow by combining a home-build counter-rotating cone-plate shear cell with transmission microscopy imaging to enable visualization of the structures while shearing.…”

Section: Introductionmentioning

confidence: 99%

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“…The nondimensional internal energy of a thin inextensible plateletẼ int = E int (θ )/(γ ηa 3 ) is given by (see, for example, Refs. [65][66][67][68])Ẽ…”

Section: Appendix: Derivation Of the Force And Torque Balance Equationsmentioning

confidence: 99%

Alignment of a flexible platelike particle in shear flow: Effect of surface slip and edges

2021

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Rigid platelike particles displaying interfacial slip can attain a constant orientation in a shear flow when the slip length is sufficiently large. But actual thin particles such as single-layer graphene are flexible and prone to bending deformations when exposed to shear stress. To study the effect of bending deformation on the dynamics of flexible platelike particles with large interfacial slip in a shear flow, we develop a two-dimensional (2D) fluid-structure interaction model. Our model is based on coupling the Euler-Bernoulli beam equation with a boundary integral method to solve the hydrodynamic stress at the particle surface. Emphasis is placed on resolving accurately the stress distribution at the edges of the particle. We find that (i) a stable alignment occurs even for relatively flexible particles and that (ii) edges effects on the shape of the plate are important for values of the length-to-thickness aspect ratio as large as 100. Our results are particularly relevant in view of recent research on the hydrodynamics of suspended flexible sheets made of 2D nanomaterials.

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Erythrocyte-erythrocyte aggregation dynamics under shear flow

Cited by 20 publications

References 45 publications

Two-dimensional hydrodynamics of a Janus particle vesicle

Two-dimensional hydrodynamics of a Janus particle vesicle

DataSheet1.pdf

Alignment of a flexible platelike particle in shear flow: Effect of surface slip and edges

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