Erythrocyte membrane fatty acid composition in children with atopic dermatitis compared to age‐matched controls

Biagi, P L; Hrelia, Silvana; Celadon, M.; Turchetto, E; Masi, Massimo; Ricci, Giorgio; Specchia, Fernando; Cannella, MV; Horrobin, D.F.; Bordoni, Alessandra

doi:10.1111/j.1651-2227.1993.tb12559.x

Cited by 28 publications

(20 citation statements)

References 7 publications

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“…Differences in the composition of colostrum, transitional milk, and mature milk during the lactation period (49,50,53) clearly indicate that milk sampling should be standardized not only with regard to sampling procedure (45) but also with regard to period of lactation. The PUFA composition of transitional human milk, however, agrees well with the reported low levels of n-6 and n-3 LC-PUFA (i.e., DHGLA, AA, EPA, DPA, and DHA) in plasma (19,20,24,57) and membrane (19,21,26,33) phospholipids in atopic children and adults.…”

Section: Human Milk Fatty Acids and Atopy-a Clue To A Further Understsupporting

confidence: 80%

“…Abnormalities in PUFA composition have been reported consistently in cellular membranes from atopic individuals (21,22,26,32,33), even in studies in which the PUFA levels in plasma phospholids were similar in atopic and nonatopic individuals (26). Although the results vary in different cells, higher LA and lower n-6 LC-PUFA and n-3 LC-PUFA are consistently found in atopic individuals (Table 3).…”

Section: Pufa and Atopic Diseasementioning

confidence: 59%

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Polyunsaturated n−3 fatty acids and the development of atopic disease

Duchén

Björkstén

2001

Lipids

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The relationship between polyunsaturated longchain fatty acids and atopy has been discussed for decades. Higher levels of the essential fatty acids linoleic acid and alpha-linolenic acid and lower levels of their longer metabolites in plasma phospholipids of atopic as compared to nonatopic individuals have been reported by several, but not all, studies. Largely similar findings have been reported in studies of cell membranes from immunological cells from atopics and non-atopics despite differences in methodology, study groups, and definitions of atopy. An imbalance in the metabolism of the n-6 fatty acids, particularly arachidonic acid and dihomo-gamma-linolenic acid, leading to an inappropriate synthesis of prostaglandin (PG) E2 and PGE1 was hypothesized early on but has not been corroborated. The fatty acid composition of human milk is dependent on the time of lactation not only during a breast meal but also the time of the day and the period of lactation. This explains the discrepancies in reported findings regarding the relationship between milk fatty acids and atopic disease in the mother. Prospective studies show disturbances in both the n-6 and n-3 fatty acid composition between milk from atopic and nonatopic mothers. Only the composition of long-chain polyunsaturated n-3 fatty acids was related to atopic development in the children, however. A relationship between lower levels of n-3 fatty acids, particularly eicosapentaenoic acid (20:5 n-3), and early development of atopic disease is hypothesized.

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Section: Human Milk Fatty Acids and Atopy-a Clue To A Further Understsupporting

confidence: 80%

Section: Pufa and Atopic Diseasementioning

confidence: 59%

Polyunsaturated n−3 fatty acids and the development of atopic disease

Duchén

Björkstén

2001

Lipids

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“…Although differences exist in the composition of colostrum, transitional and mature milk [62,66] , most studies agree on altered levels of -6 and -3 LC-PUFAs in milk of atopic mothers compared to non-atopic mothers [47,62,63] . The LC-PUFA composition of transitional human milk agrees especially well with the reported low levels of -6 and -3 LC-PUFAs in plasma [35,36,40] and membrane phospholipids [37,43,67] in atopic children and adults. The composition of LC-PUFAs in maternal milk affects the PUFA status of the child, as has been shown by several studies [68][69][70] .…”

Section: Fads Gene Cluster Polymorphisms May Modulate the Developmentsupporting

confidence: 74%

<i>FADS</i> Gene Cluster Polymorphisms: Important Modulators of Fatty Acid Levels and Their Impact on Atopic Diseases

et al. 2009

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Long-chain polyunsaturated fatty acids (LC-PUFAs) play an important role in several physiological processes and their concentration in phospholipids has been associated with several complex diseases, such as atopic disease. The level and composition of LC-PUFAs in the human body is highly dependent on their intake in the diet or on the intake of fatty acid precursors, which are endogenously elongated and desaturated to physiologically active LC-PUFAs. The most important enzymes in this reaction cascade are the Δ⁵ and Δ⁶ desaturase. Several studies in the last few years have revealed that single nucleotide polymorphisms (SNPs) in the 2 desaturase encoding genes (FADS1 and FADS2) are highly associated with the concentration of ω–6 and ω–3 fatty acids, showing that beside nutrition, genetic factors also play an important role in the regulation of LC-PUFAs. This review focuses on current knowledge of the impact of genetic polymorphisms on LC-PUFA metabolism and on their potential role in the development of atopic diseases.

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“…In particular, disorders of EFA metabolism have been evidenced, with a possible inhibition of the enzymatic activity of desaturases (3,5,(33)(34)(35). Although changes of less than 1% of the total FA were reported, they were considered to influence the normal prostaglandin production significantly (36).…”

Section: Resultsmentioning

confidence: 99%

Trans fatty acids and atopic eczema/dermatitis syndrome: The relationship with a free radical cis‐trans isomerization of membrane lipids

Ferreri

Angelini

Chatgilialoglu

et al. 2005

Lipids

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The formation of trans FA residues in membrane phospholipids may be due to a free radical-catalyzed isomerization process occurring to the cis unsaturated FA moieties. Radical stress is well documented in inflammatory processes of atopic diseases, but no data are yet available about a possible association with trans FA detected in these patients. We investigated the presence of trans lipid isomers in the erythrocyte and T-lymphocyte membranes of 26 children affected by atopic eczema/dermatitis syndrome (AEDS). Trans lipid isomers were found in both cell membranes, up to a total content of 2.7 and 4.9% of the FA composition, respectively. By using the geometrical trans lipid library derived from in vitro models of thiyl radical-catalyzed isomerization, oleic and arachidonic acid isomers were detected. The statistical significance was evaluated by comparison with an age-matched control group. These results suggest the role of an endogenous free radical isomerization path occurring to membrane unsaturated lipids, complementary to the dietary contribution, which can be involved in the lipid impairment in AEDS. This study contributes to lipidomic research regarding the double bond structure and the influence of a geometrical change of membrane lipids in physiology and diseases.

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Erythrocyte membrane fatty acid composition in children with atopic dermatitis compared to age‐matched controls

Cited by 28 publications

References 7 publications

Polyunsaturated n−3 fatty acids and the development of atopic disease

Polyunsaturated n−3 fatty acids and the development of atopic disease

<i>FADS</i> Gene Cluster Polymorphisms: Important Modulators of Fatty Acid Levels and Their Impact on Atopic Diseases

Trans fatty acids and atopic eczema/dermatitis syndrome: The relationship with a free radical cis‐trans isomerization of membrane lipids

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