Erythrocyte membranes beta-adrenoreactivity changes after renal denervation in patients with resistant hypertension, relationship with antihypertensive and cardioprotective intervention efficacy

Zyubanova, I.; Falkovskaya, A.; Mordovin, V.; Manukyan, М. A.; Pekarskij, S. E.; Lichikaki, V.; Shalishev, I. G.; Rebrova, Т. Yu.; Муслимова, Э. Ф.; Afanasiev, S. A.

doi:10.18087/cardio.2021.8.n1556

Cited by 13 publications

(3 citation statements)

References 16 publications

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“…Thus, in one of the studies it has been found that patients with high risk of cardiac complications have the EMA highest values. 15 In this study has been shown that the EMA express determination can be used as one of the criteria for the risk of adverse cardiovascular events in cardiac patients.…”

Section: Discussionmentioning

confidence: 96%

Ventricular tachycardia incidence and erythrocyte membranes β‐adrenoreactivity in patients with implanted cardioverter‐defibrillator

Atabekov

Баталов

Rebrova

et al. 2022

Pacing Clinical Electrophis

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Background:In patients with high risk of ventricular tachycardia (VT) the proven beneficial therapy is the implantable cardioverter defibrillator (ICD). It has been shown that the coronary artery disease (CAD) and VT development are accompanied by a persistent change of the sympathoadrenal system activity. This leads to a decrease in the total density of the erythrocyte membrane β-adrenergic receptors. The purpose of this study was to identify the relationship of the erythrocyte membranes βadrenoreactivity (EMA) with VT development in patients with CAD and ICD.Method: Sixty-three patients (male -53, age -66.6 ± 9.2 years) with CAD and ICD were included to the study. EMA was studied using a method for assessing erythrocyte osmoresistance increase as a result of β-adrenergic receptors blockade by a selective β-adrenergic blocker. VT and ventricular fibrillation (VF) events recorded by ICD were evaluated. Results:The 1 st group consist of 23 patients with VT/VF events recorded by ICD during 27.0 [14.0; 53.0] months follow-up period. EMA indicator in this group was 41.54% [27.15; 51.26]. The 2 nd group consist of 40 patients without VT/VF events and the same indicator was significantly higher -55. 42% [35.67; 62.33] (p = .04). The ROC-analysis (AUC = 0.657; Sen = 78.26; Spe = 55.00; p = .031) and binary logistic regression (OR = 0.9679; 95% CI: 0.9384-0.9983; p = .038) showed that EMA indicator 51.26% or lower was the independent predictor of VT events. Conclusions:In patients with CAD and ICD erythrocyte membranes βadrenoreactivity indicator 51.26% or lower is the predictor of VT episodes.

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Section: Discussionmentioning

confidence: 96%

Ventricular tachycardia incidence and erythrocyte membranes β‐adrenoreactivity in patients with implanted cardioverter‐defibrillator

Atabekov

Баталов

Rebrova

et al. 2022

Pacing Clinical Electrophis

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“…Связывание соответствующих лигандов с этими рецепторами способно влиять на свойства эритроцитов (осмотическую резистентность, скорость агглютинации и др.) [39,40].…”

Section: Discussionunclassified

Changes in the electrical and viscoelastic parameters of erythrocytes in patients with manifestations of metabolic syndrome, COVID-19 convalescents, when exposed to citicoline in an in vitro experiment

Kruchinina,

Gromov,

Kruchinina

et al. 2024

Consilium Medicum

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Aim. To study changes in the electrical and viscoelastic parameters of erythrocytes using the method of dielectrophoresis in patients with manifestations of the metabolic syndrome who underwent COVID-19, when exposed to the drug citicoline in an in vitro experiment to reduce the severity of microcirculatory disorders. Materials and methods. 31 men were examined with manifestations of metabolic syndrome (50.6±9.9 years), COVID-19 convalescences, within 8 to 12 months after the disease, the diagnosis was confirmed by PCR, ELISA. The electrical and viscoelastic parameters of erythrocytes were studied by dielectrophoresis twice: the initial levels of indicators were determined and after 30 minutes of exposure with after 30 minutes of exposure to a solution of the drug Ronocyte (oral solution with the active substance citicoline sodium – 104.50 mg., which is equivalent to 100.00 mg citicoline at a concentration of 0.01 µl per 0.3 µl of red blood cell suspension in 0.3M sucrose solution (pH 7.36). Results. Exposure of erythrocyte suspension of patients with Ronocyte solution led to change in the levels of electrical, viscoelastic parameters: an increase in the average cell diameter (p=0.0003), the proportion of discocytes (p=0.0004), the amplitude of cell deformation at high frequencies of the electric field (p=0.000002), cell capacity (p=0.000007), the velocity of erythrocytes to the electrodes (p=0.003), dipole moment (p=0.002), polarizability at 106 and 0.5×106 Hz (p=0.000019 and p=0.0015, respectively), relative polarizability (p0.05) and, conversely, to reduce summarized rigidity (p=0.000003), viscosity (p=0.000002), electrical conductivity (p0.000001), aggregation indices (p=0.00003), destruction at frequencies of 106 Hz (p=0.003), 0.5x106 Hz (p=0.00002), 0.1×106 Hz (p0.00001), polarizability at low frequencies of the electric field (p=0.02). Under the influence of the drug, the equilibrium frequency of erythrocytes shifted to the low-frequency range compared to the initial values (p0.0000001). The revealed changes indicate an increase in the surface charge of erythrocytes, their ability to deform, and cell resistance under the action of citicoline. Conclusion. For the first time, the effect of the drug with the active substance citicoline, improving the rheological properties of erythrocytes, was discovered. Preparations with the active substance - citicoline should be considered promising for conducting a full-fledged clinical study to study the reduction of circulatory disorders at the microcirculatory level in patients with manifestations of metabolic syndrome who have undergone COVID-19 coronavirus infection.

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“…Преимуществом данного метода, определяющим его доступность для реальной клинической практики, является простота использования, высокая информативность и низкая стоимость расходных материалов. В настоящее время накоплены данные об особенностях β-АРМэ у больных после инфаркта миокарда (ИМ) [8][9][10], у пациентов с хронической сердечной недостаточностью (СН) [11], а также у больных РАГ [12]. Тем не менее сведения о степени выраженности симпатической гиперактивации на основе β-АРМэ в селективной группе больных с рфАГ как крайнего фенотипа неконтролируемой АГ до настоящего времени отсутствуют.…”

Section: Beta-adrenergic Reactivity Of Erythrocyte Membranes In Vario...unclassified

Beta-adrenergic reactivity of erythrocyte membranes in various phenotypes of uncontrolled hypertension

Manukyan,

Falkovskaya,

Mordovin

et al. 2024

Russ J Cardiol

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Aim. To assess the functional state of the sympathetic nervous system according to β-adrenergic reactivity of erythrocyte membranes (EM) in patients with refractory (rfHTN) and resistant hypertension (rHTN) in relation to target organ damage.Material and methods. The cross-sectional comparative study included 78 patients with uncontrolled hypertension (mean age, 57,4±9,3 years (33 men)) with 24-hour blood pressure (BP) (systolic/diastolic) of 160,0±18,8/88,1±17,3 mm Hg. Thirty-nine (50%) patients had type 2 diabetes (T2D). At baseline, patients were divided into 2 groups depending on the phenotype of uncontrolled hypertension. The first group consisted of patients with rfHTN (n=26 (33,3%)), the second — with rHTN (uncontrolled BP with 3-4 agent therapy) (n=52 (66,7%)). In all patients, office and mean 24-hour blood pressure, EM β-adrenergic reactivity and target organ damage were assessed.Results. The compared groups did not differ in sex and age composition, prevalence of T2D and basic clinical data. However, despite comparable levels of office and mean 24-hour blood pressure, the incidence of left ventricular (LV) hypertrophy according to echocardiography in rfHTN was significantly higher than in rHTN (96,2% vs 76,9%, p=0,027, respectively). An increase in EM β-adrenergic reactivity (>20 conventional units) was documented in 87,1% of patients in the general group. Moreover, the mean EM β-adrenergic reactivity in the rfHTN group was significantly higher than in the rHTN group (51,5±18,7 vs 39,3±18,2, p=0,008). According to ROC analysis, the threshold value of EM β-adrenergic reactivity corresponding to rfHTN was ≥44,8 conventional units (sensitivity — 69,2%, specificity — 64,5%, area under the ROC curve — 0,687). The mean EM β-adrenergic reactivity in the rfHTN group did not have a direct relationship with the LV mass index, but correlated with increased pulse pressure.Conclusion. RfHTN is associated with higher EM β-adrenergic reactivity values than in patients with rHTN, which may indirectly confirm more pronounced sympathetic activity and explain the higher prevalence of LVH, realized through an increase in vascular stiffness and load on the LV.

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Erythrocyte membranes beta-adrenoreactivity changes after renal denervation in patients with resistant hypertension, relationship with antihypertensive and cardioprotective intervention efficacy

Cited by 13 publications

References 16 publications

Ventricular tachycardia incidence and erythrocyte membranes β‐adrenoreactivity in patients with implanted cardioverter‐defibrillator

Ventricular tachycardia incidence and erythrocyte membranes β‐adrenoreactivity in patients with implanted cardioverter‐defibrillator

Changes in the electrical and viscoelastic parameters of erythrocytes in patients with manifestations of metabolic syndrome, COVID-19 convalescents, when exposed to citicoline in an in vitro experiment

Beta-adrenergic reactivity of erythrocyte membranes in various phenotypes of uncontrolled hypertension

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