Erythrocyte microRNAs: a tiny magic bullet with great potential for sickle cell disease therapy

Verma, Henu Kumar; Ratre, Yashwant Kumar; Bhaskar, L. V. K. S.; Colombatti, Raffaella

doi:10.1007/s00277-020-04390-y

Cited by 8 publications

(5 citation statements)

References 59 publications

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“…Among the several erythrocytic miRNAs, miR-451 is extensively studied to understand the erythrocytic physiology under various pathophysiological conditions (19,20,23,29,36). Many studies have been conducted to determine its significance and to establish as a biomarker or therapeutic agents in various erythrocytes related disorders or diseased conditions including malaria (19,20,30,31,37). Translocation of ~100 erythrocytic miRNAs have been found in the PV formed by the parasite inside the erythrocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports indicated that, miR-451 is found to be elevated in sickle cell erythrocytes (19,76), and is associated with significantly reduced parasitaemia (19,20,77). miRNAs profile of HbAS and HbSS erythrocytes may significantly affect the parasite growth and survival (20,30,76,77). Thus, this may be the one of the protective mechanisms mediated by the host erythrocytes, which affects the intracellular parasite growth and survival (20).…”

Section: Discussionmentioning

confidence: 99%

“…This study revealed numerous interactions of miR-451a on crucial gene targets of P. falciparum, required for its growth, Erythrocytic miRNAs found in Pf-infected erythrocytes (iEs) and its connection with the pathogenesis caused by P. falciparum were identified from the literature studies on PubMed and Scopus database. Among the various erythrocytic miRNAs, miR-451a focused (15,(19)(20)(21)23,(28)(29)(30)(31) to study its regulatory role during host parasitic interactions.…”

Section: Introductionmentioning

confidence: 99%

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Functional prediction of human erythrocytic miR-451a on Plasmodium falciparum 3D7 transcriptome—an in-silico study

Joshi¹,

Patel²,

Pandya³

et al. 2021

ExRNA

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Background: Plasmodium falciparum (P. falciparum) is one of the deadliest species responsible for the major deaths related to malaria. Recently emerging research has focused on small noncoding RNAs especially mature microRNAs (miRNAs) (19-25 nts) which play regulatory role chiefly by targeting mRNAs' cleavage or translational repression. During infection, parasitic Plasmodium invades and takes command of the host cell for its survival and develops into its various life stages. Seeing that host, miRNAs considered as chief regulators of various physiological functions of the cell itself. During erythrocytic stages, possible interactions between the erythrocytic miRNAs and Plasmodium mRNAs may affect parasite biology and its survival inside the host cell. It has been also reported that during erythrocytic stages of P. falciparum, erythrocytic miRNAs may translocate into the parasite phosphorous vacuole, some of them may forming a chimera with Plasmodium mRNAs to get involved in post transcriptional regulation.Methods: In this study, one of the most abundant human erythrocytic miR-451a retrieved from miRbase and targeted on P. falciparum 3D7 transcriptome to find out the target genes and followed by annotation studies performed of targeted genes.Results: We identified crucial gene targets of P. falciparum using PSRNA target tool. Functional annotation of targeted genes and their protein products help us to understand the possible protein-protein interaction during the course of infection as well as analysis of their functions at molecular/cellular/biological level shows the significant contribution from the cytoskeletal genes which codes for the proteins like Plasmodium falciparum 3D7 erythrocyte membrane protein 1 (PfEMP1), rifin, etc. which are involved in the host membrane modifications.Conclusions: Computational approach to elucidate the erythrocytic microRNA (miRNA) targeted genes and their functional annotation studies will help to understand the possible interactions and miRNA regulatory network in malaria.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functional prediction of human erythrocytic miR-451a on Plasmodium falciparum 3D7 transcriptome—an in-silico study

Joshi¹,

Patel²,

Pandya³

et al. 2021

ExRNA

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“…Increased blood viscosity, related to HbS, may further restrict blood flow via constricted blood vessels or in normal brain capillaries. 3 – 7 …”

Section: Introductionmentioning

confidence: 99%

“…Increased blood viscosity, related to HbS, may further restrict blood flow via constricted blood vessels or in normal brain capillaries. [3][4][5][6][7] Neurological complications such as ischemic stroke, silent cerebral infarction (SCI), headache, and cognitive dysfunction are also very common in SCD. Cognitive abnormalities in SCD manifest in various aspects such as working memory, verbal learning, visuomotor function, inadequacies in general intellectual functioning, executive functions, language, and attention.…”

Section: Introductionmentioning

confidence: 99%

Neurocognitive Changes in Sickle Cell Disease: A Comprehensive Review

Sahu

Pande

Sinha

et al. 2022

Annals of Neurosciences

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Background: Sickle cell disease (SCD) is a type of hemoglobinopathy characterized by abnormal hemoglobin molecules, which includes numerous acute and chronic complications. Ischemic stroke, silent cerebral infarction, headache, and neurocognitive impairment are the most common neurological complications associated with SCD. Summary: Acute anemia because of SCD can cause cognitive impairments because of cerebral hypoxia. Cognitive abnormalities in SCD manifest in various aspects such as working memory, verbal learning, executive functions, and attention. These neurocognitive impairments have been associated with poor functional results, such as transitioning from juvenile to adult care, adherence to medications, and unemployment. Key message: In this review, we focus on neurocognitive aspects of SCD patients based on different imaging techniques, psychological batteries, associated neuromarkers, and interventions for managing of cognitive deficiencies..

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