Erythrodermic pustular psoriasis triggered by intravesical bacillus Calmette-Guérin immunotherapy

Wee, J. S.; Natkunarajah, J.; Moosa, Y.; Marsden, R.A.

doi:10.1111/j.1365-2230.2011.04183.x

Cited by 8 publications

(6 citation statements)

References 6 publications

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“…Psoriasis can be triggered post BCG vaccination [54,55]. BCG has also been used as local immunotherapy for bladder cancer, and a case of erythrodermic pustular psoriasis induced by BCG immunotherapy has been reported [56]. In a retrospective study, psoriasis was found to more frequently occur after adenovirus vaccination [57].…”

Section: Extrinsic Risk Factorsmentioning

confidence: 99%

Risk Factors for the Development of Psoriasis

Kamiya

Kishimoto

Sugai

et al. 2019

IJMS

421

306

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Psoriasis is an immune-mediated genetic skin disease. The underlying pathomechanisms involve complex interaction between the innate and adaptive immune system. T cells interact with dendritic cells, macrophages, and keratinocytes, which can be mediated by their secreted cytokines. In the past decade, biologics targeting tumor necrosis factor-α, interleukin (IL)-23, and IL-17 have been developed and approved for the treatment of psoriasis. These biologics have dramatically changed the treatment and management of psoriasis. In contrast, various triggering factors can elicit the disease in genetically predisposed individuals. Recent studies suggest that the exacerbation of psoriasis can lead to systemic inflammation and cardiovascular comorbidity. In addition, psoriasis may be associated with other auto-inflammatory and auto-immune diseases. In this review, we summarize the risk factors, which can be divided into two groups (namely, extrinsic and intrinsic risk factors), responsible for the onset and exacerbation of psoriasis in order to facilitate its prevention.

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Section: Extrinsic Risk Factorsmentioning

confidence: 99%

Risk Factors for the Development of Psoriasis

Kamiya

Kishimoto

Sugai

et al. 2019

IJMS

421

306

View full text Add to dashboard Cite

show abstract

“…However, there are few case reports that have demonstrated erythrodermic pustular psoriasis triggered by intravesical Bacillus Calmette-Guerin (BCG) immunotherapy [2], the development of psoriatic arthropathy after BCG immunotherapy for bladder carcinoma [3], and the development of sub-acute thyroiditis and dyserythropoesis after influenza vaccination suggesting immune dysregulation [4]. It is possible that the flu immunization vaccine caused a "genetic mimicry" that triggered the auto-immune response of the psoriatic patient.…”

Section: Discussionmentioning

confidence: 99%

Erythrodermic Pustular Psoriasis Triggered by Subcutaneous Flu Vaccine

Blum

Suleiman²,

Shalabi³

2013

J Clin Case Rep

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A 59-year old man was admitted with severe pustular psoriasis all over his body that was triggered by a flu vaccine injection 8 days before admission. Until then, his psoriasis was under control and was noticed slightly only on extensor tendons of the hands and around the elbows. He was treated with steroids and the skin eruption disappeared slowly within 3 days. This is the first report of a patient with psoriasis who had a flare up of the autoimmune skin disease following vaccination.

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“…In addition, an 80-year-old man with bladder carcinoma was reported with erythrodermic pustular psoriasis triggered by intravesical BCG immunotherapy. The similar mechanism with Th1 and Th17 cells generation after BCG vaccination was thought to play an important role in the pathogenesis of psoriasis [32].…”

Section: Bcg Vaccinationmentioning

confidence: 94%

“…BCG is a live attenuated strain of Mycobacterium bovis, which has been used as local immunotherapy for bladder cancer since 1976 [32]. In 1955, a psoriasis case was described following BCG vaccination under the name of 'psoriasis vaccinalis' [33].…”

Section: Bcg Vaccinationmentioning

confidence: 99%

A Review of Possible Triggering or Therapeutic Effects of Antimicrobial Vaccines on Psoriasis

Akarsu¹,

Avci²

2017

An Interdisciplinary Approach to Psoriasis

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Psoriasis is a chronic, immune-mediated disease resulting from interactions of genetic background with environmental triggering factors, such as trauma, infections and drugs. Dendritic cells, activated T-cells toward a Th1 and Th17 response and inflammatory cytokines [tumor necrosis factor (TNF)-alpha, are the key factors in psoriasis pathogenesis. Patients diagnosed with psoriasis are at increased risk of infection due to the nature of disease and immunosuppressive therapies. Vaccination is recommended to prevent infections in patients with psoriasis. Additionally, vaccines such as Mycobacterium vaccae, live attenuated varicella zoster virus and Leishmania amastigotes have been reported to induce improvement in psoriasis patients. It has been suggested that vaccines, targeting molecules in the immunopathogenesis of psoriasis, may be a new treatment option for psoriasis patients without any serious side effects. However, induction or worsening of the psoriasis and psoriatic arthritis followed by some vaccines (e.g., influenza, rubella, tetanus, BCG) has also been reported in the literature. In this review, we focus on the vaccines in psoriasis in terms of their both triggering and therapeutic effects.

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Erythrodermic pustular psoriasis triggered by intravesical bacillus Calmette-Guérin immunotherapy

Cited by 8 publications

References 6 publications

Risk Factors for the Development of Psoriasis

Risk Factors for the Development of Psoriasis

Erythrodermic Pustular Psoriasis Triggered by Subcutaneous Flu Vaccine

A Review of Possible Triggering or Therapeutic Effects of Antimicrobial Vaccines on Psoriasis

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