Erythromycin potentiates PR interval prolonging effect of verapamil in the rat: A pharmacodynamic drug interaction

Dakhel, Yaman; Jamali, Fakhreddin

doi:10.1016/j.taap.2005.11.012

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…A pharmacodynamic interaction between erythromycin and verapamil with prolongation of the PR interval has been described in rats. 48 One case of total AV block caused by concomitant use of verapamil and erythromycin has been described. 40 Erythromycin has been associated with increased risk of sudden death from cardiac causes especially in those who concurrently used CYP3A inhibitors.…”

Section: Clinical Use Of Verapamil In Cluster Headachementioning

confidence: 99%

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Verapamil for Cluster Headache. Clinical Pharmacology and Possible Mode of Action

Tfelt‐Hansen

2009

Headache

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Verapamil is used mainly in cardiovascular diseases. High-dose verapamil (360-720 mg) is, however, currently the mainstay in the prophylactic treatment of cluster headache. The oral pharmacokinetics are variable. The pharmacodynamic effect of verapamil, the effect on blood pressure, also varies considerably among subjects. The dose of verapamil used for cluster headache is approximately double the dose used in cardiovascular disease, most likely because verapamil is a substrate for the efflux transporter P-glycoprotein in the blood-brain barrier. The access of verapamil to the central nervous system is therefore limited. The clinical use of verapamil in cluster headache is reviewed and several relevant drug interactions are mentioned. Finally, its possible mode of action in cluster headache is discussed. The effect of verapamil in cluster headache most likely takes place in the hypothalamus.Verapamil is an L-type calcium channel blocker but it is also a blocker of other calcium channels (T-, P-, and possibly N-and Q-type Ca 2+ channels) and the human ether-a-go-go-related gene potassium channel. With so many different actions of verapamil, it is impossible at the present time to single out a certain mode of action of the drug in cluster headache.

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Section: Clinical Use Of Verapamil In Cluster Headachementioning

confidence: 99%

“…A pharmacodynamic interaction between erythromycin and verapamil with prolongation of the PR interval has been described in rats 48 . One case of total AV block caused by concomitant use of verapamil and erythromycin has been described 40 .…”

Section: Clinical Use Of Verapamil In Cluster Headachementioning

confidence: 99%