Escalation of intravenous fentanyl self-administration and assessment of withdrawal behavior in male and female mice
Yueyi Chen,
Tiange Xiao,
Adam Kimbrough
Abstract:BackgroundThe rise in overdose deaths from synthetic opioids, especially fentanyl, necessitates the development of preclinical models to study fentanyl use disorder (FUD). While there has been progress with rodent models, additional translationally relevant models are needed to examine excessive fentanyl intake and withdrawal symptoms.MethodsThe study performed intravenous self-administration (IVSA) of fentanyl in male and female C57BL/6J mice for 14 days. Mechanical pain sensitivity during withdrawal was asse… Show more
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