Escherichia coli

Narayan, K. G.; Sinha, Dharmendra Kumar; Singh, Dhirendra Kumar

doi:10.1007/978-981-19-7800-5_29

Cited by 2 publications

(1 citation statement)

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“…This has posed a formidable challenge in the healthcare sector due to the limited therapeutic alternatives available. Various infections caused by these pathogens such as gastroenteritis, neonatal meningitis, UTI, hemolytic-uremic syndrome, peritonitis, mastitis, pneumonia, and septicemia by E. coli [3]; septicemia, urinary tract infection (UTI), bloodstream infection, and pneumonia by K. pneumoniae [4]; cystic fibrosis, ventilator-associated pneumonia, central line-associated bloodstream infection, and catheter-related infection by P. aeruginosa [5]; meningitis, bacteremia, and pneumonia by A. baumannii [6] among the immunocompromised and hospitalized individuals are particularly troublesome from a treatment point of view. These GNB species are the primary causes of the most difficult-to-treat infections reported in India [7].…”

Section: Introductionmentioning

confidence: 99%

Colistin resistance among the Gram-negative nosocomial pathogens in India: A systematic review and meta-analysis

Dwibedy,

Padhy,

Panda

et al. 2024

Preprint

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Background The rapid rise of nosocomial infections and the growing ineffectiveness of frontline antibiotics against Gram-negative bacteria (GNB) have put the healthcare sector under unprecedented stress. In this scenario, colistin, an antibiotic of the polymyxin class, has become the last resort treatment option. The unrestricted use of colistin in the preceding decades has led to the emergence of colistin-resistant (ColR) bacterial strains. Unfortunately, comprehensive data on the prevalence of ColR nosocomial pathogens in India are lacking. This study was conducted to address this information gap and to determine the prevalence of ColR among the nosocomial GNB species in India. Methods A systematic review and meta-analysis were conducted to determine the prevalence of ColR among the nosocomial GNB species in India and their geographical distribution. A systematic search of the online databases was performed and eligible studies meeting the inclusion criteria were used for qualitative synthesis. The combined event rate and 95% confidence interval were estimated using forest plot with a random-effect model. Cochrane Q statistics and I2 statistics were used to detect possible heterogeneity. Results From a total of 1865 retrieved records from 4 databases, 36 studies were included in the study. Among the most common nosocomial pathogens, K. pneumoniae showed a rate of ColR at 17.4%, followed by P. aeruginosa (14.1%), E. coli (12.3%), and A. baumannii (12.2%). Interestingly, our analysis revealed that E. cloacae has the highest rate of ColR at 28.5%. Conclusions The level of resistance displayed by K. pneumoniae, P. aeruginosa, and to a lesser extent, E. coli and A. baumannii in the Indian subcontinent poses a challenge for public health management. Though prevalence may differ among regions and over time, continued surveillance, and efforts to curb the spread of resistance are crucial to ensure the continued effectiveness of this critical antibiotic.

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