Escherichia Coli Meningitis Treated With Sulfadiazine

The Effects of Intramuscular and Intrathecal Administration of Streptomycin in Normal Dogs and in Dogs With Meningitis Due to Escherichia Coli

“…The use of sulfonamides led to a number of reports of recovery in isolated cases,2' 6,7 but the development of streptomycin by Waksman and his associates8 offers hope of an even more effective therapy of this and related forms of meningitis. Many of the gram-negative pathogenic organisms are highly susceptible to the antibiotic effects of streptomycin and most strains of E. coli are especially sensitive to the drug (Buggs, Bronstein, Hirshfeld and Pilling9).…”