Escherichia coli STb enterotoxin

Dubreuil, J. Daniel

doi:10.1099/00221287-143-6-1783

Cited by 52 publications

(41 citation statements)

References 80 publications

(140 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…coli appartient à cette catégorie, dont l'action initiale conduit à l'augmentation du taux de Ca 2+ dans le cytosol [32]. Seules les étapes se déroulant dans les cellules épithéliales seraient dépendantes du calcium, alors que le mécanisme de libération de la 5-hydroxytryptamine (5-HT) par les cellules entéro-chromaffines de la base des villosités serait indépendant du calcium [61].…”

Section: Voie Du Calciumunclassified

Les récepteurs des entérotoxines bactériennes

Rousset

2000

Vet. Res.

View full text Add to dashboard Cite

-Bacterial enterotoxin receptors. Enteric bacterial toxins display a great diversity in their structure, molecular weight and mechanism of action. The interaction of enterotoxins with the intestinal mucosa either leads to a direct effect on the cell membrane or an effect on signal transduction within eukaryotic cells. However, before a toxin can affect a cell, it must after its secretion by a microorganism, recognise and bind to a specific surface molecule, its receptor. Membrane receptors of bacterial enterotoxins have been identified as protein, glycoprotein or glycolipid in nature. The chemical nature of the molecules acting as receptors is crucial and during evolution they have been carefully selected. Some toxins, after their interaction with a receptor molecule, will transduce a signal across the cell membrane while remaining at the cell surface. Other toxins, after this initial binding step with a receptor, will be internalised. Others can form pores leading to leakage of cellular components and cell lysis. Receptors that have been identified often comprise a saccharidic chain that is directly involved in the recognition and binding of the toxin. Today, models explaining toxin-receptor interactions are more complex, including multistep events. This review summarises the knowledge of the interactions between bacterial toxins and membrane receptors present on intestinal mucosa. receptor / intestine / enterotoxin / binding epitope / glycosphingolipidRésumé -Les toxines bactériennes entériques présentent une grande diversité autant dans leur structure que dans leur poids moléculaire et leur mécanisme d'action. L'interaction des entérotoxines avec la muqueuse intestinale conduit soit à un effet direct sur la paroi cellulaire de la cellule hôte, soit à un dérèglement des voies de signalisation de celle-ci. Toutefois, avant même d'affecter la cellule cible, la toxine sécrétée par le micro-organisme devra reconnaître et s'attacher à une molécule présente à la surface cellulaire, son récepteur. Les récepteurs membranaires des entérotoxines bactériennes peuvent être de nature protéique, glycoprotéique ou glycolipidique. La nature chimique de ces récepteurs, sur laquelle repose la spécificité, est primordiale et au cours de l'évolution ceuxci ont été soigneusement sélectionnés. Certaines toxines, une fois en contact avec leur récepteur, envoient un signal à l'intérieur de la cellule tout en demeurant à la surface alors que d'autres toxines sont internalisées. Enfin, certaines toxines bactériennes peuvent former des pores dans la membrane Vet. Res. 31 (2000)

show abstract

Section: Voie Du Calciumunclassified

Les récepteurs des entérotoxines bactériennes

Rousset

2000

Vet. Res.

View full text Add to dashboard Cite

show abstract

“…Activation of the ENS by PGE 2 and 5-HT was observed for STb (Sears and Kaper, 1996;Dubreuil, 1997). The release of 5-HT can act on the ENS to contract smooth muscle in the intestinal wall to augment the peristaltism (Guttman and Finlay, 2008).…”

Section: Stbmentioning

confidence: 99%

“…STb has been reported in human isolates (Lortie et al, 1991;Handl and Flock, 1992;Okamoto et al, 1993) but this toxin is mostly associated with porcine ETEC and the majority of porcine ETEC produces STb (Dubreuil, 1997).…”

Section: Stbmentioning

confidence: 99%

The Whole Shebang: The Gastrointestinal Tract,Escherichia coliEnterotoxins and Secretion

2012

Current Issues in Molecular Biology

View full text Add to dashboard Cite

This review focuses on diarrhea caused by toxins released by enterotoxigenic Escherichia coli. These bacteria are known to produce toxins that have adverse effects on the intestinal tissue in Man and animals. E. coli is contracted through the ingestion of water or food contaminated by this bacterium. Generally, E. coli colonizes the intestinal mucosa where it multiplies and causes damage to the target cells or interferes with the homeostasis that prevails in the gastrointestinal tract. Enteropathogens such as E. coli are only able to exhibit their effects after colonization of the intestinal mucosa from where they release their toxins. These bacteria mainly affect chloride ions secretion through second messenger pathways resulting in secretory diarrhea. In this review, the association of bacteria with the gastrointestinal tract as pathogens and the resulting effects on the various systems of the intestine, including the nervous system and mediators leading to secretion and diarrhea are examined.

show abstract

“…Heat-stable enterotoxin b (STb) is one of the toxins produced by ETEC strains responsible for the induction of diarrhea and is most commonly associated with post-weaning diarrhea in piglets aged over one week [3,4].…”

Section: Introductionmentioning

confidence: 99%