Esomeprazole 40 mg administered intravenously (IV) as a 3-minute injection or 30-minute infusion provides the same effective acid control in healthy subjects

Wilder‐Smith, Clive H.; Röhss, Kerstin; Bondarov, Patrik; Lundin, Christina; Nilsson-Pieschl, Catharina

doi:10.1016/s0016-5085(03)81171-x

Cited by 6 publications

(10 citation statements)

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“…One report showed that 3- or 30-minute intravenous esomeprazole (40 mg) provides similar levels of intragastric acid control to the oral formulation, [23,24] although little is known about the pharmacokinetic profile of esomeprazole after intravenous administration (whereas that of the oral formulation is well characterized). [1,2] Niazi et al [25] demonstrated that a higher infusion rate of intravenous esomeprazole showed higher C max values, but did not affect other values such as the plasma concentration–time curve, plasma elimination half-life ( t 1/2 ), or plasma clearance in healthy volunteers.…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis associated with single-dose intravenous esomeprazole administration

Jeon

Kim

et al. 2016

Medicine

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Background:Proton pump inhibitors are usually safe, although serious adverse effects can occur. We report the first case of rhabdomyolysis associated with single-dose intravenous esomeprozole administration.Methods:A 45-year-old Korean male visited our emergency room because of persistent lower chest discomfort that started 10 hours before. He had been diagnosed with diabetes and coronary heart disease, but discontinued oral hypoglycemic agents 1 month earlier. He continued to take medications for coronary heart disease. There was no abnormality on an electrocardiogram or in cardiac enzymes. Initial laboratory findings did not show abnormalities for muscle enzymes. Esomeprozole 40 mg was administrated intravenously for the control of his ambiguous chest discomfort. Then, 12 hours later, he complained of abrupt severe right buttock pain. An area of tender muscle swelling 8 cm in diameter was seen on his right buttock area. Creatine kinase and lactate dehydrogenase were elevated to 40,538 and 1326 U/L, respectively. A bone scan using 20 mCi of 99mTc-hydroxymethylene diphosphonate was compatible with rhabdomyolysis.Results:His muscular symptoms, signs, and laboratory findings improved markedly with conservative management, including hydration and urine alkalinization. He is being followed in the outpatient department with no evidence of recurrence.Conclusion:We should keep in mind that single-dose intravenous administration of esomeprazole can induce rhabdomyolysis.

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Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis associated with single-dose intravenous esomeprazole administration

Jeon

Kim

et al. 2016

Medicine

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“…infusion of esomeprazole 40 mg has been shown to provide a similar level of acid control to oral administration in healthy subjects and to provide a slightly faster onset of action on day 1 of dosing 14 . It has also been shown that a 3‐min injection and a 30‐min infusion provide similar levels of intragastric acid control 15 . The i.v.…”

Section: Introductionmentioning

confidence: 98%

Esomeprazole 40 mg i.v. provides faster and more effective intragastric acid control than pantoprazole 40 mg i.v.: results of a randomized study

Wilder‐Smith

Röhss

Bondarov

et al. 2004

Aliment Pharmacol Ther

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SUMMARYBackground: Oral esomeprazole 40 mg provides greater acid control than oral pantoprazole 40 mg. Aim: To compare the effects on intragastric acid control of esomeprazole 40 mg administered intravenously with pantoprazole 40 mg intravenously. Methods: Healthy Helicobacter pylori-negative male and female subjects were enrolled into this single-centre, open, randomized, two-way crossover study. Esomeprazole 40 mg intravenously and pantoprazole 40 mg intravenously were administered as 15-min infusions once daily at 09:00 hours for 5 days. Continuous 24-h intragastric pH monitoring was carried out at baseline and on days 1 and 5.

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“…Data from previous studies using i.v. administration of esomeprazole have revealed no difference in acid control when the infusion time was changed between 3 and 30 min [6]. Thus, in this study, infusions in group A and B lasted for 15 min as in previous pantoprazole i.v.…”

Section: Methodsmentioning

confidence: 57%

“…Data from previous studies have revealed no differences in acid control when, for i.v. administration of esomeprazole, infusion time was extended from 3 to 30 min [6]. In the previously conducted studies using pantoprazole i.v., the medication was given in a 15-min infusion [7,8].…”

Section: Discussionmentioning

confidence: 99%

Effect of intravenous application of esomeprazole 40???mg versus pantoprazole 40???mg on 24-hour intragastric pH in healthy adults

Hartmann

Eickhoff

Damian

et al. 2007

European Journal of Gastroenterology & Hepatology

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Esomeprazole 40 mg administered intravenously (IV) as a 3-minute injection or 30-minute infusion provides the same effective acid control in healthy subjects

Cited by 6 publications

References 0 publications

Rhabdomyolysis associated with single-dose intravenous esomeprazole administration

Rhabdomyolysis associated with single-dose intravenous esomeprazole administration

Esomeprazole 40 mg i.v. provides faster and more effective intragastric acid control than pantoprazole 40 mg i.v.: results of a randomized study

Effect of intravenous application of esomeprazole 40???mg versus pantoprazole 40???mg on 24-hour intragastric pH in healthy adults

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