Esomeprazole-based sequential therapy and probiotic for Helicobacter pylori eradication

Abstract

PURPOSE: The objective of the present study was to determine the effectiveness of esomeprazole-based sequential therapy and Bio Gaya probiotic for the treatment of Helicobacter pylori-infection (Hp-infection) with associated gastroduodenal diseases. MATERIAL AND METHODS:The study covered 104 patients with dominating upper dyspeptic syndrome and Hp-infection examined by means of two or more methods. Esomeprazole-based sequential therapy consisted in amoxycillin in a dose of 1,0 g two times daily for the first five days followed by clarithromycin and metronidazole in a dose of 500 mg two times daily for the next 5 days. A Bio Gaya probiotic was added during the 10-day treatment. RESULTS: Hp-infection was successfully treated in 98 patients (94,2%) and in 79 out of 81 naive ones (97% of the cases). This therapy proved effective in