2004
DOI: 10.1002/ijc.20267
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Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression

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Cited by 75 publications
(37 citation statements)
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“…Overexpression of PCNA, a biomarker for cell proliferation (Kimos et al 2004), was observed in 87.76% (43/49) of the tumor tissues compared with the adjacent…”
Section: Correlation Between Level Of Ezrin Protein and Cell Prolifermentioning
confidence: 99%
“…Overexpression of PCNA, a biomarker for cell proliferation (Kimos et al 2004), was observed in 87.76% (43/49) of the tumor tissues compared with the adjacent…”
Section: Correlation Between Level Of Ezrin Protein and Cell Prolifermentioning
confidence: 99%
“…Expression levels of PCNA correlate positively with other pathological indices in prostate cancer (Mulligan et al, 1997) and can serve as an independent prognosis marker (Miyamoto et al, 2006). Overexpression of PCNA is also a reliable biomarker for other tumor types (Kimos et al, 2004;Cappello et al, 2006;Stuart-Harris et al, 2008). These findings suggest that PCNA could be a valuable target for cancer therapy.…”
Section: Introductionmentioning
confidence: 98%
“…PCNA gene deregulation and post-translational modulation are hallmarks of malignant cells. Tumor cells, regardless of their origins, express higher levels of PCNA (Celis and Olsen, 1994;Kallakury et al, 1999;Kimos et al, 2004;Malkas et al, 2006;Miyamoto et al, 2006;Naryzhny and Lee, 2007;Eltz et al, 2008;Naryzhny, 2008;Stuart-Harris et al, 2008;Zhong et al, 2008;Stoimenov and Helleday, 2009). Expression levels of PCNA correlate positively with other pathological indices in prostate cancer (Mulligan et al, 1997) and can serve as an independent prognosis marker (Miyamoto et al, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…Tumor cells, regardless of their origin, express high levels of PCNA, presumably to accommodate their high degree of uncontrolled replication (21). For these reasons, PCNA is a reliable diagnostic and prognostic biomarker (21)(22)(23)(24)(25)(26)(27)(28).…”
Section: Introductionmentioning
confidence: 99%