Esophagitis in Frail Elderly People

Cardin, Franco; Minicuci, Nadia; Siviero, Paola; Bertolio, Serena; Gasparini, Giulia; Inelmen, Eminè Meral; Terranova, O.

doi:10.1097/01.mcg.0000225611.48728.1e

Cited by 13 publications

(7 citation statements)

References 18 publications

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“…In addition, at present, it is not fully understood which additional risk factors contribute to the development of reflux esophagitis or what influence these factors might have on disease severity. Possible risk factors reported include overweight, male gender, history of GERD, smoking habit, absence of Helicobacter pylori or presence of hiatal hernia 1–3, 10–13 . As far as severe esophagitis is concerned, the clinical data suggest a relationship with severity of symptoms, presence of heartburn for more than five years, obesity, presence of hiatal hernia, male gender and Caucasian ethnicity 14 , 15 …”

Section: Introductionmentioning

confidence: 99%

“…14,15 Finally, the role of drugs in the pathogenesis of severe esophagitis is especially controversial and has been only partially evaluated. While the use of PPIs is considered to be a protective factor, 11,16 the role of other drugs such as anticholinergics, 17 nitrates 11,18 and tricyclic antidepressants, calcium antagonists or sulcralfate 11 is more debatable. In particular, the results of studies of the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) have been contradictory.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of severe esophagitis in Spain. Results of the PRESS study (Prevalence and Risk factors for Esophagitis in Spain: A cross‐sectional study)

et al. 2016

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Background: The current prevalence of esophagitis in southern Europe is unknown. In addition, the risk factors for reflux esophagitis are not fully understood. Objective: The objective of this article is to assess the prevalence and risk factors for esophagitis in Spain. Methods: A prospective, observational, cross-sectional, multicenter study (PRESS study) was conducted among 31 gastrointestinal endoscopy units throughout Spain. A total of 1361 patients undergoing upper gastrointestinal endoscopy were enrolled. Sociodemographic, clinical and treatment data were recorded. Results: A total of 95% of patients were Caucasian and 52% were male (mean age: 53 AE 17 years). The most frequent symptoms prompting endoscopy were heartburn (40%), regurgitation (26%) and dysphagia (15%). Fifty-four percent of patients undergoing endoscopy were receiving proton pump inhibitor (PPI) treatment. Esophagitis (mainly mild-moderate) was present in 154 (12.4%) patients. The severe form was recorded in only 11 (0.8%) patients. Multivariate analysis results indicated that the likelihood of esophagitis was higher in men (OR ¼ 1.91, 95% CI ¼ 1.31-2.78), in patients with high GERD-Q scores (OR ¼ 1.256, 95% CI ¼ 1.176-1.343), weight increase (OR ¼ 1.014, 95% CI ¼ 1.003-1.025) and high alcohol consumption (OR ¼ 2.49, 95% CI ¼ 1. 16-5.36). Conclusion: Severe esophagitis is a rare finding in the Spanish population. Male gender, high GERD-Q score, weight increase and high alcohol consumption are main risk factors for its appearance.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of severe esophagitis in Spain. Results of the PRESS study (Prevalence and Risk factors for Esophagitis in Spain: A cross‐sectional study)

et al. 2016

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“…In our study, osteoporosis and sarcopenia were associated with frailty in a univariate analysis, so GERD symptom generation due to osteoporosis and sarcopenia may be related to the onset of frailty. Cardin et al reported that being bedridden was an independent risk factor for esophagitis, that esophagitis exacerbates frailty in hospitalized elderly people, and that its identification may be helpful in these patients ( 23 ). Therefore, the management of GERD symptoms may be important for the prevention of frailty.…”

Section: Discussionmentioning

confidence: 99%

The Association between Frailty and Abdominal Symptoms: A Hospital-based Cross-sectional Study

et al. 2020

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Objective The association between frailty and abdominal symptoms has not been evaluated. Methods We conducted a hospital-based, retrospective cross-sectional study of consecutive outpatients ≥65 years old at the Department of Gastroenterology, Juntendo Tokyo Koto Geriatric Medical Center from 2017 to 2019. Patients were included in the study if all of the following information was available from their medical records: patient's profile, the evaluation of osteoporosis, sarcopenia, frailty, nutritional status, findings of upper gastrointestinal endoscopy, and questionnaire results for abdominal symptoms [Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (FSSG) and Constipation Scoring System (CSS)]. We divided the subjects into frailty and non-frailty groups and investigated the risk factors for frailty. Results Of the 313 eligible study subjects [134 men (42.8%) and 179 women (57.2%); mean age, 75.7±6.0 years; mean body mass index, 22.8±3.6 kg/m 2 ], frailty was noted in 71 cases (22.7%). In a univariate analysis, an older age (p<0.001), female gender (p=0.010), successful eradication of Helicobacter pylori (p=0.049), proton pump inhibitor (PPI) use (p<0.001), laxative/prokinetics use (p=0.008), sarcopenia (p<0.001), osteoporosis (p<0.001), hypozincemia (p=0.002), hypoalbuminemia (p<0.001), low lymphocytes (p=0.004), a high CONUT score (p<0.001), a high FSSG score (p=0.001), and a high CSS score (p<0.001) were significantly associated with frailty. A multivariate logistic regression analysis showed that an older age [odds ratio (OR) 1.16; 95% confidence interval (CI) 1.08-1.24, p<0.001], PPI use (OR 2.42; 95% CI 1.18-4.98, p=0.016), sarcopenia (OR 7.35; 95% CI 3.30-16.40, p<0.001), hypozincemia (OR 0.96; 95% CI 0.92-0.99, p=0.027), a high FSSG score (OR 1.08; 95% CI 1.01-1.16, p=0.021), and a high CSS score (OR 1.13; 95% CI 1.03-1.23, p=0.007) were significantly associated with frailty. Conclusion Advanced age, PPI user, sarcopenia, hypozincemia, a high FSSG score, and high CSS score are associated with frailty.

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“…Eine diagnostizierte Frailty anhand etablierter Frailty−Instru− mente beeinflusst weiter per se den Verlauf einer vorbestehen− den chronischen Erkrankung in negativer Weise. Dies gilt für die koronare Herzkrankheit [13], Schlaganfall [14], Alzheimer'sche Demenz [15], Morbus Parkinson [16], venöse Thrombosen [17] sowie die Ösophagitis [18]. Kürzlich konnte am Beispiel des Prostatakarzinoms und einer hormonsupprimierenden Therapie bei älteren Männern die sinnhafte Anwendbarkeit der Frailty−Diagnose für therapeuti− sche Indikationsstellungen aufgezeigt werden [19].…”

Section: Definitionen Von Frailtyunclassified

Frailty: Ein geriatrisches Syndrom im Fokus der Ernährungsmedizin

Sieber¹

2008

Akt Ernähr Med

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Esophagitis in Frail Elderly People

Abstract: These findings seem to substantiate the theory that esophagitis is a characteristic which exacerbates frailty in hospitalized elderly people and its identification may be helpful in these patients.

Cited by 13 publications

References 18 publications

Prevalence of severe esophagitis in Spain. Results of the PRESS study (Prevalence and Risk factors for Esophagitis in Spain: A cross‐sectional study)

Prevalence of severe esophagitis in Spain. Results of the PRESS study (Prevalence and Risk factors for Esophagitis in Spain: A cross‐sectional study)

The Association between Frailty and Abdominal Symptoms: A Hospital-based Cross-sectional Study

Frailty: Ein geriatrisches Syndrom im Fokus der Ernährungsmedizin

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