ESR detection and dosimetric properties of irradiated naproxen sodium

Free radicals properties of gamma-irradiated penicillin-derived antibiotics: piperacillin, ampicillin, and crystalline penicillin

“…Free radicals formed in sterilized drugs may have an effect not only on the pharmacological activity of the drug (Polat and Korkmaz 2003), but also on its pharmacokinetic properties (Gibella et al 2000), which is often neglected in the scientific literature.…”

“…Unfortunately, it is not possible to predict the influence of ionizing radiation on the stability of radicals even if the considered compounds are similar, because even minor changes in molecular structure may have a significant influence on processes observed by EPR spectroscopy (Polat and Korkmaz 2003). As expected, even though they belong to the same group of antibiotics, the sterilized substances investigated in the present study show very different properties under the influence of gamma radiation.…”

Sterility and Radio Stability of Amoxicillin and Cefaclor Antibiotics Sterilized by Gamma Irradiation

“…These collective results disagree with those obtained by [28] who reported that the sterilized penicillin-derived antibiotics: piperacillin, ampicillin, and crystalline penicillin antibiotics drugs following gamma sterilization showed very different properties therefore may reduce the therapeutic properties of the pharmaceuticals. Free radicals formed in sterilized drugs may have an not on the activity of the drug [29], but also on its pharmacokinetic properties [30], which is often neglected in the scientific literature.…”

Effect of gamma radiation on amlodis and its potential for radiosterilization

“…Gamma radiation processing is a well-proven technique for achieving safe and effective sterilization of disposable medical devices and other medicinal products and also for improvement of the hygienic quality of foods [1][2][3][4][5][6][7]. Its major advantage is due to its high penetrating power and the very small temperature rise induced.…”

“…In this context, it is necessary to find methods of distinguishing between irradiated and non-irradiated pharmaceuticals. Electron spin resonance (ESR), which is a very sensitive method for detection of free radicals, can be used for detection of irradiated drugs [7,[9][10][11][12][13][14] as already used elsewhere for foodstuffs irradiated [15][16][17].…”