Essential Dynamic Transformation as Specific Highly Characterizable Indices of Progression of the Initial Mild Cognitive Impairment Phase of Alzheimer Patients

Abstract

Dynamics of transforming potential underlie the systems of heterogeneous progression to a final demented state in Alzheimer patients. Such dynamics reflect many of the attributes of an essentially variable vascular series of substrates that implicate various component systems of the blood brain barrier as endothelium and also of the subcortical structures and cortex as further delineated by systems of heterogeneous nature in progression of the mild cognitive impairment of Alzheimer type. Transforming dynamics of initial mild phases of cognitive impairment come to assume a dominant profile determination that characterises the subsequent emergence of neuronal lesions and of neuronal cell loss as suggested by development of synaptic pathology and as further projected by the development of neuritic plaques and neurofibrillary tangles. Amyloid-beta is a recognizable feature of Alzheimer pathology that evolves as accumulative dimensions of such Alzheimer pathology.