Essential Oil and Phenolic Compounds ofArtemisia herba-alba(Asso.): Composition, Antioxidant, Antiacetylcholinesterase, and Antibacterial Activities

Abstract

Total phenols, flavonoids, flavonols, and flavanols of the methanolic extract of the aerial part of Artemisia herba-alba were determined. The extract was analyzed by liquid chromatography with photodiode array coupled with electrospray ionisation mass spectrometry and allowed to identify of 10 phenolic compounds. Apigenin-6-C-glycosyl flavonoids and caffeoylquinic acids were identified. Chlorogenic acid and 1,4 dicaffeoylquinic acid being the major constituents. The essential oil obtained by hydrodistillation was analyzed by gas chromatography-mass spectrometry. Twenty-three compounds, representing 97.8% of the total oil, were identified. The most abundant components were βthujone (41.9%), α-thujone (18.4%), and camphor (13.2%). Methanolic extract and essential oil exhibited a considerable antioxidant activity as evaluated by 2,2-diphenyl-pycrilhydrazil hydrate scavenging activity, reducing power, β-carotene bleaching test, and chelating ability. The methanolic extract was found to be more efficient, while the essential oil exhibited the highest acetylcholinesterase inhibitory activity. Analysis of the antibacterial activity showed that A. herba-alba methanolic extract and essential oil are efficient against gram positive and gram negative bacteria.

Asteraceae Artemisia campestris and Artemisia herba-alba Essential Oils Trigger Apoptosis and Cell Cycle Arrest in Leishmania infantum Promastigotes

“…The other samples had a high proportion of borneol and thujone [42]. Recently, we studied the essential oil of an A. ha sample from Kairouan (Central Tunisia, upper arid bioclimate) and we found β -thujone (41.9%) as the major compound [29]. In other countries like Jordan, oxygen-containing monoterpenes represent also the main compounds of the oil [43].…”

“…An amount of 150 g of ground material of each species was hydrodistilled in 1 L of water during 3 hours in a clevenger type apparatus. The obtained oil was dried using anhydrous sodium sulphate, centrifuged, weighed, and then stored at 4°C until analyses [29]. The oil yield was calculated in terms of % of its dry weight.…”

“…The compositions of the essential oils were determined, as described previously [29], by GC/MS with an Agilent Technologies 7890A apparatus equipped with a HP-5MS fused silica column (30 m × 0.25 mm; 0.25  μ m film thickness) and split mode injection (split ratio 1 : 50) where the oil samples were diluted in 50% hexane before injection. Mass spectrometry (MS) analysis was performed on an Agilent mass selective detector 5975 C inert MSD.…”

“…A. ha has been shown previously to contain methylated flavonoids such as Hispidulin and Cirsilineol [27, 28]. More recently, our team has showed that methanolic extract from A. ha was mainly represented by C-glycosyl flavonoids and caffeoylquinic acids [29]. …”

Antioxidative and xanthine oxidase inhibitory activities and phytochemical screening of the hydro-alcoholic extract of mace, aril of Myristica fragrans: Implication as an adjuvant therapy in gout

“…Natural products obtained from dietary and non-dietary sources are an armamentarium of pharmacological agents that have the potential to make a difference in the way alternative therapies are used in disease prevention. Studies have reported the pharmacological significance and associated health benefits of a number of spices used in various ethnic cuisines and food cultures worldwide [42][43][44].Modern medicine has revolutionized treatment strategies in the current period. However, in the light of emerging drug resistance in the cases of antibiotics and anti-cancer drugs, associated ill effects, organ toxicities, and expensive commercial interests leading to inaccessibility, it is believed to be judicious to have alternative strategies, such as prophylactic interventions, for most diseases associated with poor lifestyles, including stressful conditions, such as diabetes and gout.…”