Essential oil components with antidiabetic and anti-obesity properties: a review of mechanisms of action and toxicity

Ejiofor, Emmanuel; Oyedemi, Sunday; Egedigwe-Ekeleme, Chima; Obike, Chiemeziem; Aguwamba, Chinedu; Nweje-Anyalowu, Paul; Ejiofor, Maureen; Okwuonu, Oluchi

doi:10.1080/10412905.2023.2236625

Cited by 6 publications

(1 citation statement)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result, high glucose and glycated hemoglobin levels were reduced. In addition, the study reported that during the use of nerolidol, liver integrity was preserved, and the regulation of insulin-dependent glucose transport was improved in skeletal muscles due to the activation of GLU4 (Glucose transporter type 4) [ 87 , 88 ]. It is also worth mentioning that another substance with reported antihyperglycemic activity in the literature is caryophyllene, also identified in the essential oil of M. multiflora , which showed significant antidiabetic effects on glucose homeostasis in diabetic rats at a dose of 200 mg/kg (body weight) [ 89 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

Exploring the Potential of Myrcia Genus Essential Oils: A Review of Biological Activities and Recent Advances

dos Santos,

Bezerra,

da Silva

et al. 2024

Molecules

View full text Add to dashboard Cite

The present study provides a comprehensive analysis of the chemical composition of essential oils from species of the Myrcia genus and their applications. The compiled results highlight the chemical diversity and biological activities of these oils, emphasizing their potential importance for various therapeutic and industrial applications. The findings reveal that Myrcia essential oils present a variety of bioactive compounds, such as monoterpenes and sesquiterpenes, which demonstrate antimicrobial activities against a range of microorganisms, including Gram-positive and Gram-negative bacteria, as well as yeasts. Furthermore, this study highlights the phytotoxic activity of these oils, indicating their potential for weed control. The results also point to the insecticidal potential of Myrcia essential oils against a range of pests, showing their viability as an alternative to synthetic pesticides. Additionally, species of the genus Myrcia have demonstrated promising hypoglycemic effects, suggesting their potential in diabetes treatment. This comprehensive synthesis represents a significant advancement in understanding Myrcia essential oils, highlighting their chemical diversity and wide range of biological activities. However, the need for further research is emphasized to fully explore the therapeutic and industrial potential of these oils, including the identification of new compounds, understanding of their mechanisms of action, and evaluation of safety and efficacy in different contexts.

show abstract

Section: Biological Activitiesmentioning

confidence: 99%

Exploring the Potential of Myrcia Genus Essential Oils: A Review of Biological Activities and Recent Advances

dos Santos,

Bezerra,

da Silva

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

Oral administration of tannic acid attenuates dyslipidemia, hyperglycemia, and oxidative stress in high‐fat and fructose diet‐induced obesity in rats

Ejiofor,

Agwamba,

Egedigwe‐Ekeleme

et al. 2024

Food Safety and Health

View full text Add to dashboard Cite

Obesity and diabetes are considered life‐threatening conditions, characterized by increased oxidative stress, insulin resistance, hepatotoxicity, hyperglycemia, and hypercholesterolemia. Therefore, we studied the effects of tannic acid in a high‐fat and fructose‐diet‐induced rat model of obesity. Administration of tannic acid at doses of 200 and 400 mg/kg significantly reduced fasting blood glucose concentration, reversed disoriented lipid profile, decreased liver enzyme activities, and inhibited oxidative stress compared to the high‐fat, high‐sugar group. Histopathological examination showed preserved pancreas and liver architecture in the tannic acid‐administered groups. The in vitro inhibitory activity of tannic acid against alpha‐amylase, alpha‐glucosidase, and pancreatic lipase showed good inhibitory potential. Molecular docking studies showed high binding affinity and more hydrogen bond interactions between tannic acid and receptor proteins (alpha‐amylase, alpha‐glucosidase, and pancreatic lipase) implicated in obesity and diabetes. In conclusion, tannic acid prevented the onset of oxidative stress, preserved the liver, and restored the disoriented lipid profile in high‐fat and fructose diet‐induced obesity in rats.

show abstract

Linalool as a key component in strawberry volatile organic compounds (VOCs) modulates gut microbiota, systemic inflammation, and glucolipid metabolism

Tan,

Zhao,

Luo

et al. 2024

Food Chemistry

View full text Add to dashboard Cite

Essential oil components with antidiabetic and anti-obesity properties: a review of mechanisms of action and toxicity

Cited by 6 publications

References 140 publications

Exploring the Potential of Myrcia Genus Essential Oils: A Review of Biological Activities and Recent Advances

Exploring the Potential of Myrcia Genus Essential Oils: A Review of Biological Activities and Recent Advances

Oral administration of tannic acid attenuates dyslipidemia, hyperglycemia, and oxidative stress in high‐fat and fructose diet‐induced obesity in rats

Linalool as a key component in strawberry volatile organic compounds (VOCs) modulates gut microbiota, systemic inflammation, and glucolipid metabolism

Contact Info

Product

Resources

About