Essential Oil Composition and Bioactivities of Waldheimia glabra (Asteraceae) from  Qinghai-Tibet Plateau

De, Ji; Lu, Yan; Ling, Liuyi; Peng, Nan; Zhong, Yang

doi:10.3390/molecules22030460

Cited by 19 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent references mention e.g. 32% a-thujone in Cotula cinerea (Ghouti et al 2018), 51.8% a-thujone and 14.6% b-thujone in Anthemis mixta (Tadrent et al 2016), 84% b-thujone in Senecio chrysanthemoides (Mengi et al 1995) or 5.7% athujone may appear in some accessions of Waldheimia glabra (De et al 2017). Characteristically, these thujone-accumulating species of the family are not closely related to each other, either botanically or geographically.…”

Section: Occurence Of Thujone In Aromatic Plants Chemotaxonomic Aspectsmentioning

confidence: 99%

Thujone, a widely debated volatile compound: What do we know about it?

Németh

Nguyen

2020

Phytochem Rev

View full text Add to dashboard Cite

Thujone is a volatile monoterpene ketone of plant origin which is produced by several plants that are frequently used for flavoring foods and beverages. The use of thujone and thujone-containing plant parts for human consumption is currently regulated by the European Parliament and Council and the European Medicines Agency. The best known neurotoxic effects are connected to the GABA-gated chloride channel, where a-thujone is a modulator roughly two to three times as potent as the b isomer. Based primarily on in vitro experiments, genotoxicity and carcinogenic properties of thujones have also been detected in parallel with antimutagenic and immune-modulatory effects. Some of the controversial effects seem to be strongly dose-dependent. Data on antidiabetic and antimicrobial activities of thujones may show new ways to use them. This review also describes the main steps of the biosynthetic route of thujones and their occurrence in the plant kingdom. The accumulation of these compounds seems to be more abundant in some plant families (e.g. Asteraceae or Cupressaceae) than in others. Four species (Artemisia absinthium, Salvia

show abstract

Section: Occurence Of Thujone In Aromatic Plants Chemotaxonomic Aspectsmentioning

confidence: 99%

Thujone, a widely debated volatile compound: What do we know about it?

Németh

Nguyen

2020

Phytochem Rev

View full text Add to dashboard Cite

show abstract

“…Bioactive components were mostly represented by mono-terpenes with piperitone, camphor and ethyl cinnamate as the main compounds [54]. Similarly, NOinhibiting activity was determined in the EO derived from the Chinese traditional herb Waldheimia glabra (Decne), where α-bisabolol, valeranone and chamazulene were dominating compounds [55]. Anti-inflammatory activity also has been determined in EO derived from Hibiscus sabdariffa L., with n-Hexadecanoic acid as the most abundant volatile component.…”

Section: In Vitro Raw 2647 Macrophage Test Systemmentioning

confidence: 99%

Potential Application of the Plant-Derived Essential Oils for Atherosclerosis Treatment: Molecular Mechanisms and Therapeutic Potential

et al. 2023

View full text Add to dashboard Cite

Essential oils (EOs) are complex secondary metabolites identified in many plant species. Plant-derived EOs have been widely used in traditional medicine for centuries for their health-beneficial effects. Some EOs and their active ingredients have been reported to improve the cardiovascular system, in particular to provide an anti-atherosclerotic effect. The objective of this review is to highlight the recent research investigating the anti-inflammatory, anti-oxidative and lipid-lowering properties of plant-derived EOs and discuss their mechanisms of action. Also, recent clinical trials exploring anti-inflammatory and anti-oxidative activities of EOs are discussed. Future research on EOs has the potential to identify new bioactive compounds and invent new effective agents for treatment of atherosclerosis and related diseases such as diabetes, metabolic syndrome and obesity.

show abstract

“…BCP has been recognized in the essential oil of Waldheimia glabra (Decne.) Regel, popularly known as 'Ghaan-Poe', is used for influenza in Tibetan medicine (Manzo et al, 2016;De et al, 2017). The essential oil showed antiviral activity against influenza virus H3N2 in an in vitro assay and was found comparable to ribavirin, a standard antiviral drug (Manzo et al, 2016).…”

Section: Antiviral Properties Of Bcpmentioning

confidence: 99%

β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19

et al. 2021

View full text Add to dashboard Cite

Coronavirus disease (COVID-19), caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic and presents a public health emergency. It has affected millions of people and continues to affect more, despite tremendous social preventive measures. Identifying candidate drugs for the prevention and treatment of COVID-19 is crucial. The pathogenesis and the complications with advanced infection mainly involve an immune-inflammatory cascade. Therefore, therapeutic strategy relies on suppressing infectivity and inflammation, along with immune modulation. One of the most promising therapeutic targets for the modulation of immune-inflammatory responses is the endocannabinoid system, particularly the activation of cannabinoid type 2 receptors (CB2R), a G-protein coupled receptor which mediates the anti-inflammatory properties by modulating numerous signaling pathways. To pharmacologically activate the CB2 receptors, a naturally occurring cannabinoid ligand, beta-caryophyllene (BCP), received attention due to its potent anti-inflammatory, antiviral, and immunomodulatory properties. BCP is recognized as a full selective functional agonist on CB2 receptors and produces therapeutic effects by activating CB2 and the nuclear receptors, peroxisome proliferator-activated receptors (PPARs). BCP is regarded as the first dietary cannabinoid with abundant presence across cannabis and non-cannabis plants, including spices and other edible plants. BCP showed tissue protective properties and favorably modulates numerous signaling pathways and inhibits inflammatory mediators, including cytokines, chemokines, adhesion molecules, prostanoids, and eicosanoids. Based on its pharmacological properties, molecular mechanisms, and the therapeutic potential of BCP as an immunomodulator, anti-inflammatory, organ-protective, and antiviral, we hypothesize that BCP could be a promising therapeutic and/or preventive candidate to target the triad of infection, immunity, and inflammation in COVID-19. In line with numerous studies that proposed the potential of cannabinoids in COVID-19, BCP may be a novel candidate compound for pharmaceutical and nutraceutical development due to its unique functional receptor selectivity, wide availability and accessibility, dietary bioavailability, nonpsychoactivity, and negligible toxicity along with druggable properties, including favorable pharmacokinetic and physicochemical properties. Based on reasonable pharmacological mechanisms and therapeutic properties, we speculate that BCP has potential to be investigated against COVID-19 and will inspire further preclinical and clinical studies.

show abstract

Essential Oil Composition and Bioactivities of Waldheimia glabra (Asteraceae) from Qinghai-Tibet Plateau

Cited by 19 publications

References 17 publications

Thujone, a widely debated volatile compound: What do we know about it?

Thujone, a widely debated volatile compound: What do we know about it?

Potential Application of the Plant-Derived Essential Oils for Atherosclerosis Treatment: Molecular Mechanisms and Therapeutic Potential

β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19

Contact Info

Product

Resources

About