Essential Oil Composition and Biological Activities of <i>Aegle marmelos</i> (L.) Correa Grown in Western Ghats Region-South India

Poonkodi, Kathirvel; Vimaladevi, Krishnasamy; Suganthi, M.; Gayathri, N.

doi:10.1080/0972060x.2019.1653796

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…The obtained results are almost similar in Thailand, Vietnam and southern Karnataka origin. Since there were some differences in their composition, due to climatic and geographical changes 19 .…”

Section: Resultsmentioning

confidence: 99%

Chemical Profile and Biological Activities of Essential oil from Artabortrys hexapetalus (L.f.) Bhandari Grown in Southern Parts of Western Ghats

Vimaladevi¹,

Selladurai²,

Poonkodi³

et al. 2022

Orient. J. Chem

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In this invistigation, we assessed the composition of the essential oil from the leaves of Artabortrys hexapetalus (L.f.) Bhandari, in vitro antioxidant and anticancer activities. The hydrodistilled essential oil from A. hexapetalus leaves cultivated in the southern Western Ghats was evaluated by GC/MS for its chemical composition. 34 compounds were present, according to the results of GC/MS analysis. The predominant constituents include Caryophyllene (17.2%), Copaene (12.9%), α-Bisabolene (8.3%), Biocyclogermacrene (6.3%), α-Cadinol (6.2%), β-Myrcene (5.7%), δ- 3-Carene (5.3%), and γ-Muurolene (4.9 %). The minor constituents are Gurjunene (3.5%), Longipinane (3.5%), Patchoulene (3.1%), Trans cadinal (2.8%), Ledol (1.4%), α-Phellandrene (1.3%), and Patchouli alcohol (1.3%). The DPPH and ABTS assays were used to measure the antioxidant activity of the A. hexapetalus essential oil, with ascorbic acid as a reference. The essential oil demonstrated antioxidant activity by having IC50 values of 104 and 122 µl/mL, respectively. Further the essential oil has tested its in vitro anticancer potential using the MTT assay on the HeLa cancer cell line and showed significant anticancer activity with an IC50 value of 36.7 µg/mL.

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Section: Resultsmentioning

confidence: 99%

Chemical Profile and Biological Activities of Essential oil from Artabortrys hexapetalus (L.f.) Bhandari Grown in Southern Parts of Western Ghats

Vimaladevi¹,

Selladurai²,

Poonkodi³

et al. 2022

Orient. J. Chem

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“…They reported that it might inhibit the proliferation of human leukemic-K562, B-lymphoid Raji, T-lymphoid-Jurkat, erythro-leukemic HEL, melanoma-Colo38, and breast cancer-MCF7 and MDA-MB-231 tumor cell lines [41]. Poonkodi and coworkers (2019) studied Western Ghats Region-South India Aegle marmelos (L.) Correa essential oil that showed significant antiproliferative effects against HeLa (human cervical cancer cell line) and less sensitivity against the African Monkey-Kidney normal cell line, Vero [13]. Several other studies also supported the anticancer effects of the essential oil of A. marmelos leaves [2].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have been conducted to determine the antioxidant properties of A. marmelos leaf essential oil [3,47]. The antioxidant activity may be due to limonene or other compounds in A. marmelos leaf essential oil [13,48].…”

Section: Discussionmentioning

confidence: 99%

“…The vast repertoire of studies that focus on the anticancer properties exhibited by essential oils is a testament to their immense potential in healthcare. One such study highlights how Aegle marmelos leaves possess remarkable anticancer activity when subjected to rigorous scientific scrutiny, thus making it an ideal candidate for further research into developing novel therapies for cancer treatment [12,13]. Worldwide, mortality related to oral cavity cancer increased to 1.40-fold during the past three decades [14].…”

Section: Introductionmentioning

confidence: 99%

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Aegle marvels (L.) Correa Leaf Essential Oil and Its Phytoconstituents as an Anticancer and Anti-Streptococcus mutans Agent

et al. 2023

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Aegle mamelons (A. marmelos) or Indian Bael leaves possess anti-cancerous and antibacterial properties and are used in the traditional medicine system for the treatment of oral infections. In the present study, the essential oil of the leaves of A. marmelos was explored for its anticancer, antioxidant, and anti-cariogenic properties. The hydro-distilled oil of A. marmelos leaves was analyzed using gas chromatography coupled with mass spectrometry (GC-MS). Monoterpene limonene (63.71%) was found to have the highest percentage after trans-2-Hydroxy-1,8-cineole and p-Menth-2,8-dien-1-ol. The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay was used to investigate the anticancer activity of the extracted oil against human oral epidermal carcinoma (KB), and the results showed significantly higher (**** p < 0.0001) anticancer activity (45.89%) in the doxorubicin (47.87%) when compared to the normal control. The antioxidant activity of the essential oil was evaluated using methods of DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)). The results showed a significant (*** p < 0.001) percentage of inhibition of DPPH-induced free radical (70.02 ± 1.6%) and ABTS-induced free radical (70.7 ± 1.32%) at 100 µg/mL with IC50, 72.51 and 67.33 µg/mL, respectively, comparatively lower than standard compound ascorbic acid. The results of the molecular docking study of the significant compound limonene with the receptors tyrosinase and tyrosine kinase 2 supported the in vitro antioxidant potential. The anti-cariogenic activity was evaluated against Streptococcus mutans (S. mutans). Results showed a significant minimum inhibitor concentration of 0.25 mg/mL and the killing time was achieved at 3 to 6 h. The molecular-docking study showed that limonene inhibits the surface receptors of the S. mutans c-terminal domain and CviR protein. The study found that A. marmelos leaves have potential anti-carcinoma, antioxidant, and anti-cariogenic effects on human oral epidermal health, making them a valuable natural therapeutic agent for managing oral cancer and infections.

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“…It demonstrates a high cytotoxic effect against HeLa cells compared to doxorubicin, with an IC 50 4.7 µg/mL [101]. Aegle marmelos EO demonstrates a cytotoxic potential at IC 50 of 85.6 µg/mL against HeLa cells due to its major compounds, p-mentha-1,4(8)-diene (33.2%) and limonene (13.1%) [102]. Other herbal EOs that contain monoterpenes as their major constituents, such as Aloysia citriodora (α-citral 43.46-47.62%), Crassocephalum crepidioides (β-myrcene 65.9%), and Litsea cubeba (geranial 37.67%), reported cytotoxicity to HeLa cells [103][104][105].…”

Section: Essential Oils With High Monoterpenesmentioning

confidence: 99%

Essential Oils in Cervical Cancer: Narrative Review on Current Insights and Future Prospects

Abd Rashid,

Mohamad Najib,

Abdul Jalil

et al. 2023

Antioxidants

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Cervical cancer is a prevalent and often devastating disease affecting women worldwide. Traditional treatment modalities such as surgery, chemotherapy, and radiation therapy have significantly improved survival rates, but they are often accompanied by side effects and challenges that can impact a patient’s quality of life. In recent years, the integration of essential oils into the management of cervical cancer has gained attention. This review provides an in-depth exploration of the role of various essential oils in cervical cancer, offering insights into their potential benefits and the existing body of research. The review also delves into future directions and challenges in this emerging field, emphasizing promising research areas and advanced delivery systems. The encapsulation of essential oils with solid lipid nanoparticles, nanoemulsification of essential oils, or the combination of essential oils with conventional treatments showed promising results by increasing the anticancer properties of essential oils. As the use of essential oils in cervical cancer treatment or management evolves, this review aims to provide a comprehensive perspective, balancing the potential of these natural remedies with the challenges and considerations that need to be addressed.

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Essential Oil Composition and Biological Activities of Aegle marmelos (L.) Correa Grown in Western Ghats Region-South India

Cited by 9 publications

References 20 publications

Chemical Profile and Biological Activities of Essential oil from Artabortrys hexapetalus (L.f.) Bhandari Grown in Southern Parts of Western Ghats

Chemical Profile and Biological Activities of Essential oil from Artabortrys hexapetalus (L.f.) Bhandari Grown in Southern Parts of Western Ghats

Aegle marvels (L.) Correa Leaf Essential Oil and Its Phytoconstituents as an Anticancer and Anti-Streptococcus mutans Agent

Essential Oils in Cervical Cancer: Narrative Review on Current Insights and Future Prospects

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