Essential oil composition, antioxidant and antimicrobial activity of the galbuli of six juniper species

Zheljazkov, Valtcho D.; Kačániová, Miroslava; Dincheva, Ivayla; Radoukova, Tzenka; Semerdjieva, Ivanka; Astatkie, Tess; Schlegel, Vicki

doi:10.1016/j.indcrop.2018.08.013

Cited by 58 publications

(38 citation statements)

References 41 publications

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“…Its higher antioxidant activity in the ABTS assay may be due to the predominance of oxygenated terpenes, reported as more effective in neutralizing free radicals, quenching singlet and triplet oxygen, decomposing peroxides and chelating transition metals [80]. The lowest antioxidant power shown by J. oxycedrus EO, instead, may be due to its high relative content (over 35%) of α-pinene, for which a negative relationship with the antioxidant activity has been reported [81]. The contribution of single EO compounds to their antioxidant activity is still object of many debates.…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition, Antioxidant, Anti-Tyrosinase, Anti-Cholinesterase and Cytotoxic Activities of Essential Oils of Six Algerian Plants

et al. 2020

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In this study, the essential oils (EOs) of six Algerian plants (Artemisia campestris L., Artemisia herba-alba Asso, Juniperus phoenicea L., Juniperus oxycedrus L., Mentha pulegium L. and Lavandula officinalis Chaix) were obtained by hydrodistillation, and their compositions determined by GC-MS and GC-FID. The antioxidant activity of the EOS was evaluated via 2,2′-diphenyl-1-picrylhydrazyl (DPPH), ferric-reducing/antioxidant power (FRAP) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assays. Moreover, their cytotoxic effect was evaluated—as well as their tyrosinase, acetyl- and butyryl-cholinesterase (AChE and BuChE) inhibitory activities. The chemical analyses detected 44, 45, 51, 53, 26 and 40 compounds in EOs of A. campestris, A. herba-alba, J. phoenicea, J. oxycedrus, M. pulegium and L. officinalis, respectively. A. campestris EO was mainly composed of β-pinene (20.7%), while A. herba-alba EO contained davanone D (49.5%) as the main component. α-Pinene (41.8%) was detected as the major constituent in both J. phoenicea (41.8%) and J. oxycedrus (37.8%) EOs. M. pulegium EO was characterized by pulegone as the most abundant (76.9%) compound, while linalool (35.8%) was detected as a major constituent in L. officinalis EO. The antioxidant power evaluation revealed IC50 values ranging from 2.61 to 91.25 mg/mL for DPPH scavenging activity, while the FRAP values ranged from 0.97–8.17 µmol Trolox equivalents (TX)/g sample. In the ABTS assay, the values ranged from 7.01 to 2.40 µmol TX/g sample. In the presence of 1 mg/mL of the samples, tyrosinase inhibition rates ranged from 11.35% to 39.65%, AChE inhibition rates ranged from 40.57% to 73.60% and BuChE inhibition rates ranged from 6.47% to 72.03%. A significant cytotoxic effect was found for A. herba-alba EO. The obtained results support some of the traditional uses of these species in food preservation and for protection against several diseases.

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Section: Discussionmentioning

confidence: 99%

Chemical Composition, Antioxidant, Anti-Tyrosinase, Anti-Cholinesterase and Cytotoxic Activities of Essential Oils of Six Algerian Plants

et al. 2020

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“…Recently, nanoemulsion drug delivery systems have been applied successfully in the treatment of colon cancers (Huang, Wei, Inbraj, & Chen, 2015), Among all natural products, some essential oils have been considered to have dramatic antibacterial, antiviral, antioxidant, and anticancer activities (Donsi & Ferrari, 2016;Pejin, Iodice, Bogdanovic, Kojic, & Tesevic, 2017). A large number of essential oils have been widely studied in medicine and food industry (Atares & Chiralt, 2016;Zheljazkov et al, 2018).…”

Section: The Particle Size Of Nanoemulsion Is Between 20 and 200 Nmmentioning

confidence: 99%

Synthesis ofCarum Carviessential oil nanoemulsion, the cytotoxic effect, and expression of caspase 3 gene

et al. 2019

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Scientists are attempting to find novel methods to overcome cancers. Nanoemulsion systems as the novel drug delivery tools have been widely used in cancer therapy. In this study, the Carum Carvi oil nanoemulsions (CCONE) were prepared and its cytotoxic activity was studied on human colon cancer HT‐29 cells using MTT assay. Flow cytometry and Real‐time qPCR were triggered to evaluate the nanoemulsions' apoptotic properties. The results showed a significant negative association between the HT‐29 cancer cell viability and CCONE doses of treatments compared with Huvec normal cells (p value < 0.001). The IC50 values were estimated 12.5 µg/ml and 50 µg/ml for HT‐29 and Huvec, respectively. Moreover, we observed that increasing concentrations of nanoemulsions significantly upregulate Caspase‐3 gene expression. The results showed the CCONE is an efficient novel apoptosis inducer for human colon cancer cells without any undesirable side effects. However, further in vitro and in vivo researches are required. Practical applications Cancer is a complex and usually untreatable disorder. Several types of cancer therapy strategies have been applied widely to overcome cancers. Chemotherapy has been used in various types of cancers. In most cases, not only it had not been effective on cancer cells but also been distractive within normal tissues. According to results, Carum Carvi essential oil nanoemulsions have apoptotic and cytotoxic effects on colon cancer cells (HT‐29). When it comes to cancer of any kind, it's important to realize that no dietary supplement can fully treat, cure, or prevent cancer. However, there are some supplements that can potentially decrease the risk of cancer. Nanoemulsions present several advantages including the ability to incorporate hydrophilic, amphiphilic, and lipophilic excipient ingredients, high physical stability, and rapid gastrointestinal digestibility. The Carum Carvi essential oil nanoemulsion can also be applied as an effective food supplement due to its potent apoptotic activity.

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“…The antibacterial activity has been tested against Staphylococcus aureus, Escherichia coli, Shigella sonei, Yersinia enterocolitica and Streptococcus pneumoniae (Eryi git et al 2014;Radoukova et al 2018;Salamon et al 2019). The EO from J. communis berries was more bioactive than the EO extracted from its leaves against Gram-positive (G+ve) and Gram-negative (GÀve) bacteria (Haziri et al 2013;Falcão et al 2018;Zheljazkov et al 2018). Moreover, the possible cytotoxic activity of the EOs from different juniper species has been reported (Topҫu et al 2005;El-Sawi et al 2007;Maurya et al 2018;Vasilijevi c et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Biological investigations of essential oils extracted from threeJuniperusspecies and evaluation of their antimicrobial, antioxidant and cytotoxic activities

Elshafie

Caputo

Martino

et al. 2020

J. Appl. Microbiol.

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Aims: To conduct biological investigations and to evaluate the antimicrobial and antioxidant activities of the essential oils (EOs) extracted from Juniperus communis, J. scopulorum and J. horizontalis; to screen their mechanisms of action by conducting the cell membrane permeability assay (CMP); and to determine the possible cytotoxicity of the three EOs against human neuroblastoma cells (SH-SY5Y). Methods and Results: The antifungal activity was tested against four phytopathogenic fungi (Monilinia fructicola, Aspergillus niger, Penicillium expansum and Botrytis cinerea). The antibacterial activity was evaluated against two Gram-positive (G+ve) (Bacillus megaterium and Clavibacter michiganensis) and three Gram-negative (GÀve) bacterial strains (Pseudomonas fluorescens, P. syringae pv. phaseolicola and Xanthomonas campestris). Results showed that the three tested EOs have antifungal activity against M. fructicola and P. expansum and effective antibacterial activity against P. syringae pv. phaseolicola and B. megaterium. Moreover, the three EOs were evaluated for their ability to inhibit the growth of SH-SY5Y cells with MTT assay. J. communis EO was the more effective with an IC 50 of 53Á7 lg ml À1. The antioxidant capacity of the three EO did not differ as measured by the DPPH assay. Conclusions: The three tested juniper EOs showed promising antimicrobial and antioxidant activity and cytotoxic effects against human neuroblastoma cell line. Significance and Impact of the Study: The outfindings from this research showed promising antimicrobial effects of the three oils against the majority of the tested phytopathogens with a potential to utilize them as natural alternatives to synthetic drugs, the cause of global environmental problems, pathogen resistance and difficulty to control many post-harvest plant diseases.

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Essential oil composition, antioxidant and antimicrobial activity of the galbuli of six juniper species

Cited by 58 publications

References 41 publications

Chemical Composition, Antioxidant, Anti-Tyrosinase, Anti-Cholinesterase and Cytotoxic Activities of Essential Oils of Six Algerian Plants

Chemical Composition, Antioxidant, Anti-Tyrosinase, Anti-Cholinesterase and Cytotoxic Activities of Essential Oils of Six Algerian Plants

Synthesis ofCarum Carviessential oil nanoemulsion, the cytotoxic effect, and expression of caspase 3 gene

Biological investigations of essential oils extracted from threeJuniperusspecies and evaluation of their antimicrobial, antioxidant and cytotoxic activities

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