Essential oil from Eugenia stipitata McVaugh leaves has antinociceptive, anti-inflammatory and antipyretic activities without showing toxicity in mice

Costa, Wêndeo Kennedy; Oliveira, João Ricardhis Saturnino de; Oliveira, Alisson Macário de; Santos, Izabelly Bianca da Silva; Cunha, Rebeca Xavier da; Freitas, Anderson Felipe Soares de; Silva, Janderson Weydson Lopes Menezes da; Silva, Valquíria Bruna Guimarães; Aguiar, Júlio César de Oliveira Farias de Ribeiro; Silva, Alexandre Gomes da; Navarro, Daniela Maria do Amaral Ferraz; Lima, Vera Lúcia de Menezes; Silva, Márcia Vanusa da

doi:10.1016/j.indcrop.2019.112059

Cited by 39 publications

(16 citation statements)

References 57 publications

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“…20 Likewise, the EO of the leaves from the Brazilian Northeast was characterized by guaiol (13.7%) and E -caryophyllene (11.3%). 21 The variability in the chemical compositions of Eugenia spp. may be related to the environmental differences of the collection sites since this is a factor that can influence chemotypes varieties.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Cytotoxic Activities of Myrtaceae Essential Oils Rich in Terpenoids From Brazil

Jerônimo

Costa

Pinto

et al. 2021

Natural Product Communications

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This work analyzed the chemical compositions and evaluated the antioxidant and cytotoxic activities of essential oils (EO) of Eugenia patrisii (Epat), Eugenia stipitata (Esti), Myrcia splendens (Mspl), Myrcia sylvatica (Msyl), Psidium guajava (Pgua), and Psidium guineense (Pgui-1 and Pgui-2) from the Brazilian Amazon. Sesquiterpenoids were found in high concentrations in the oils of E. patrisii and M. splendens, which were rich in E-caryophyllene (32.0% and 45.8%); E. stipitata and M. sylvatica, which displayed germacrene D (11.8%) and germacrene B (24.5%); and P. guajava that showed epi-β-bisabolol (16.1%) as the main compound. However, P. guineense samples (Pgui-1 and Pgui-2) were rich in monoterpenoids such as limonene (Pgui-1: 30.2%; Pgui-2 30.4%) and α-pinene (Pgui-1: 22.5%; Pgui-2: 17.7%). The samples showed a weak and moderate antioxidant activities in the DPPH assay, displaying inhibition rates from 11.5% to 38.6% (at 10 mg/mL). All samples were cytotoxic against human cancer cells by the MTT method. Epat oil showed higher activity against melanoma (SKMEL-19, IC505.8 µg/mL), gastric (AGP01, IC503.2 µg/mL), and colon (HCT116, IC506.7 µg/mL). Meanwhile, the samples Pgua and Pgui were more active against breast cancer cells (MCF7, IC5012.4 µg/mL and 11.6 µg/mL, respectively).

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Section: Resultsmentioning

confidence: 99%

Antioxidant and Cytotoxic Activities of Myrtaceae Essential Oils Rich in Terpenoids From Brazil

Jerônimo

Costa

Pinto

et al. 2021

Natural Product Communications

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“…No quesito sensorial, a fruta se destaca possuindo uma polpa carnuda, suculenta, aromática e levemente ácida (W. K. Costa et al, 2020), características comuns em frutos tropicais e muito apreciado tanto para consumo in natura quanto para preparo de sucos e doces.…”

Section: Introductionunclassified

Comportamento higroscópico da polpa de Araçá-boi (Eugenia stipitata) em pó obtida pelo método de liofilização com diferentes concentrações de maltodextrina

Andrade

Ferreira

Lima

et al. 2021

RSD

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Esse estudo objetivou-se avaliar as características físico-químicas do pó de Araçá-boi liofilizado, e o comportamento higroscópico utilizando isotermas de adsorção e diferentes modelos matemáticos. As formulações da polpa de Araçá-boi com diferentes concentrações de maltodextrina (14, 21 e 28%) foram congeladas em freezer à -18 °C, em seguida, desidratadas em liofilizador de bancada. Foram determinados os parâmetros de teor de água, sólidos totais, pH e acidez titulavel. As isotermas de adsorção de água do pó de Araçá-boi nas temperaturas de 25, 30 e 35 °C foram determinadas usando o método especial indireto estático, utilizando o higrômetro Aqualab, para medir a atividade de água. Os modelos de Henderson, Oswin, Halsey, GAB e Peleg foram ajustados às isotermas de adsorção de água utilizando regressão não linear. A partir do coeficiente de determinação (R2) e do desvio percentual médio (P), verificou-se que, entre os modelos estudados e considerando as temperaturas testadas, os valores de R2 obtidos em GAB, Halsey e Peleg estão tão próximos entre si que, no pior dos casos, não superam 0,9% de diferença. A melhor representação matemática das isotermas foi obtida pelo modelo de GAB, uma vez que apresentou os menores valores para Xm, sendo, portanto, o modelo que melhor explica o ganho de água.

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“…In the present work, the sample that had the highest toxicity was from July (dry), that had LC 50 (14.45 ± 0.25 μg·mL −1 ) ( Table 6 ), which presented as main constituents β-phellalandrene and elemicin ( Table 3 ). In general, all the essential oil fractions tested had LC50 < 100 μg·mL −1 values, which means that essential oils have high toxicity [ 43 ], and values > 1000 μg·mL −1 can be considered of low toxicity [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Preliminary Toxicity Evaluation of the Essential Oil from Peperomia circinnata Link var. circinnata. (Piperaceae) in Artemia salina Leach

et al. 2021

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Peperomia Ruiz and Pav, the second largest genus of the Piperaceae, has over the years shown potential biological activities. In this sense, the present work aimed to carry out a seasonal and circadian study on the chemical composition of Peperomia circinata essential oils and aromas, as well as to evaluate the preliminary toxicity in Artemia salina Leach and carry out an in silico study on the interaction mechanism. The chemical composition was characterized by gas chromatography (GC/MS and GC-FID). In the seasonal study the essential oil yields had a variation of 1.2–7.9%, and in the circadian study the variation was 1.5–5.6%. The major compounds in the seasonal study were β-phellandrene and elemicin, in the circadian they were β-phellandrene and myrcene, and the aroma was characterized by the presence of β-phellandrene. The multivariate analysis showed that the period and time of collection influenced the essential oil and aroma chemical composition. The highest toxicity value was observed for the essential oil obtained from the dry material, collected in July with a value of 14.45 ± 0.25 μg·mL−1, the in silico study showed that the major compounds may be related to potential biological activity demonstrated by the present study.

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Essential oil from Eugenia stipitata McVaugh leaves has antinociceptive, anti-inflammatory and antipyretic activities without showing toxicity in mice

Cited by 39 publications

References 57 publications

Antioxidant and Cytotoxic Activities of Myrtaceae Essential Oils Rich in Terpenoids From Brazil

Antioxidant and Cytotoxic Activities of Myrtaceae Essential Oils Rich in Terpenoids From Brazil

Comportamento higroscópico da polpa de Araçá-boi (Eugenia stipitata) em pó obtida pelo método de liofilização com diferentes concentrações de maltodextrina

Chemical Composition and Preliminary Toxicity Evaluation of the Essential Oil from Peperomia circinnata Link var. circinnata. (Piperaceae) in Artemia salina Leach

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