Essential Oils as Alternative Promising Anti-Candidal Agents: Progress and
Prospects

Shala, A. Y.; Singh, Shweta; Hameed, Saif; Khurana, M

doi:10.2174/1381612827666210914124344

Cited by 5 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secondary metabolites derived from many plants and microorganisms are valuable natural compounds. Many natural products have significant biological activities, such as anti-tumor activity, antibacterial activity [ 63 , 64 , 65 ]. The antagonistic effect of the strain is mainly due to the production of natural secondary metabolites, such as antibiotics and antimicrobial peptides [ 66 , 67 , 68 ].…”

Section: Inhibitory Nature Metabolites Produced By Diverse Antagonistsmentioning

confidence: 99%

Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds

Jin

Zhang

et al. 2022

Antibiotics

View full text Add to dashboard Cite

Candida albicans is an endogenous opportunistic pathogenic fungus that is harmless when the host system remains stable. However, C. albicans could seriously threaten human life and health when the body’s immune function declines or the normal flora is out of balance. Due to the increasing resistance of candidiasis to existing drugs, it is important to find new strategies to help treat this type of systemic fungal disease. Biological control is considered as a promising strategy which is more friendly and safer. In this review, we compare the bacteriostatic behavior of different antagonistic microorganisms (bacteria and fungi) against C. albicans. In addition, natural products with unique structures have attracted researchers’ attention. Therefore, the bioactive nature products produced by different microorganisms and their possible inhibitory mechanisms are also reviewed. The application of biological control strategies and the discovery of new compounds with antifungal activity will reduce the resistance of C. albicans, thereby promoting the development of novel diverse antifungal drugs.

show abstract

Section: Inhibitory Nature Metabolites Produced By Diverse Antagonistsmentioning

confidence: 99%

Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds

Jin

Zhang

et al. 2022

Antibiotics

View full text Add to dashboard Cite

show abstract

“…Nevertheless, Candida albicans, C. glabrata, C. tropicalis, C. parapsilosis and C. krusei have been pointed out as the most prevalent strains in invasive candidiasis. Since several reviews have largely covered the antifungal potential of essential oils on these pathogens [68][69][70][71][72], we now focus on a once considered rare species, Candida auris, that is currently emerging as a major pathogen in certain parts of the world. C. auris infections are difficult to treat as this pathogen does not respond to conventional antifungal drugs.…”

Section: Essential Oils In Respiratory Candidiasismentioning

confidence: 99%

Essential Oils in Respiratory Mycosis: A Review

Zuzarte

Salgueiro

2022

Molecules

View full text Add to dashboard Cite

Respiratory mycosis is a major health concern, due to the expanding population of immunosuppressed and immunocompromised patients and the increasing resistance to conventional antifungals and their undesired side-effects, thus justifying the development of new therapeutic strategies. Plant metabolites, namely essential oils, represent promising preventive/therapeutic strategies due to their widely reported antifungal potential. However, regarding fungal infections of the respiratory tract, information is disperse and no updated compilation on current knowledge is available. Therefore, the present review aims to gather and systematize relevant information on the antifungal effects of several essential oils and volatile compounds against the main type of respiratory mycosis that impact health care systems. Particular attention is paid to Aspergillus fumigatus, the main pathogen involved in aspergillosis, Candida auris, currently emerging as a major pathogen in certain parts of the world, and Cryptococcus neoformans, one of the main pathogens involved in pulmonary cryptococcosis. Furthermore, the main mechanisms of action underlying essential oils’ antifungal effects and current limitations in clinical translation are presented. Overall, essential oils rich in phenolic compounds seem to be very effective but clinical translation requires more comprehensive in vivo studies and human trials to assess the efficacy and tolerability of these compounds in respiratory mycosis.

show abstract

“…However, due to the progressive emergence of fungal resistance and its side effects, as well as treatment costs, the use of Gels 2023, 9, 799 2 of 13 conventional antibiotics now shows major limitations for antifungal treatment. On the other hand, essential oils, apart from having lower toxicity and better biodegradability, are eco-friendly in nature as compared with conventional antibiotics [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Design and Characterization of Citronella Oil-Loaded Micro-Emulgel for the Treatment of Candida Albicans Infection

Singh,

Chauhan,

Gupta

et al. 2023

Gels

View full text Add to dashboard Cite

The purpose of the current study was to prepare and evaluate a citronella oil-loaded microemulsion-based micro-emulgel for the treatment of Candida albicans. The primary objective was to use the skin to transfer hydrophobic medications into the bloodstream. The formulation included cinnamon oil as an antifungal oil and citronella oil as an active pharmaceutical ingredient, respectively. Tween 80 and PEG 200 were used as the surfactant and co-surfactant, respectively, to create phase diagrams. Carbopol 940, one of the frequently used polymers, was investigated for its ability to prepare gel formulations. The optimized (F3) batch contained the highest percentage (87.05 ± 0.03%) of drug content and, according to the statistics provided, had the highest drug release rate of around 87.05% within 4 h. The Korsmeyer–Peppas model with n value of 0.82, which is in the range 0.5–1, had the highest r2 value, indicating that release following non-Fickian/anomalous diffusion provided a better dimension for all of the formulations. The optimized (F3) formulation had stronger antifungal activity in comparison to other formulations. This leads to the conclusion that citronella oil can be made into a micro-emulgel, which may improve its release in aqueous systems while maintaining a high level of drug release at the target site.

show abstract

Essential Oils as Alternative Promising Anti-Candidal Agents: Progress and Prospects

Cited by 5 publications

References 0 publications

Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds

Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds

Essential Oils in Respiratory Mycosis: A Review

Design and Characterization of Citronella Oil-Loaded Micro-Emulgel for the Treatment of Candida Albicans Infection

Contact Info

Product

Resources

About