Essential Oils Derived from Cistus Species Activate Mitochondria by Inducing SIRT1 Expression in Human Keratinocytes, Leading to Senescence Inhibition

Ledrhem, Merieme; Nakamura, Miku; Obitsu, Miyu; Hirae, Kinue; Kameyama, Jun; Bouamama, Hafida; Gadhi, Chemseddoha; Katakura, Yoshinori

doi:10.3390/molecules27072053

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…Due to its large use in Mediterranean traditional medicines [6], the Cistus genus has been widely studied, revealing the presence of specialized metabolites endowed with antioxidant, antimicrobial, anti-inflammatory, and neuroprotective properties [3][4][5][6]10,11].…”

Section: Discussionmentioning

confidence: 99%

“…The glandular trichomes present on the leaves of these plants produce a characteristic resin named ladano, which is responsible for the aromatic scent and contains compounds of pharmacological interest [1,3,7]. Although each species has a distinct phytochemical profile, terpenoids (sesquiterpenes, diterpenes, monoterpenes), polyphenols (flavonoids, tannins, and phenolic acids), coumarins, and alkaloids are commonly found in the aerial parts of Cistus species [8][9][10][11]. Moreover, their essential oils contain mainly monoterpenes, sesquiterpenes, and diterpenes [8].…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Anti-Inflammatory and Antioxidant Potential, Metabolite Composition and Inorganic Profile of Cistus monspeliensis L. Aerial Parts and Roots

Mac Sweeney,

Chiocchio,

Mandrone

et al. 2024

Antioxidants

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This work focuses on Cistus monspeliensis L. aerial parts (AP) and roots (R) extracts, investigating the anti-inflammatory and antioxidant potential of the two organs in comparison. At dosages between 1.56 and 6.25 µg/mL, both extracts showed a protective effect against LPS inflammatory stimulus on a macrophage cell line (RAW 264.7). Interestingly, only R was able to significantly reduce both IL-1β and IL-6 mRNA gene expression in the presence of LPS. Moreover, the treatment of a neuroblastoma cell line (SH-SY5Y) with AP and R at 6.25 µg/mL increased the cell survival rate by nearly 20% after H2O2 insult. However, only R promoted mitochondria survival, exhibited a significantly higher production of ATP and a higher activity of the enzyme catalase than the control. Both AP and R had similar primary metabolites; in particular, they both contained 1-O-methyl-epi-inositol. Labdane and methoxylated flavonoids were the most characteristic compounds of AP, while R contained mainly catechins, gallic acid, and pyrogallol derivatives. Considering the importance of elemental composition in plants, the inorganic profile of AP and R was also investigated and compared. No potentially toxic elements, such as Pb, were detected in any sample.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the Anti-Inflammatory and Antioxidant Potential, Metabolite Composition and Inorganic Profile of Cistus monspeliensis L. Aerial Parts and Roots

Mac Sweeney,

Chiocchio,

Mandrone

et al. 2024

Antioxidants

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“…For example, several Cistus spp. oils significantly attenuated UVB-induced cellular senescence in a keratinocyte cell line (HaCaT) [87], while Cymbopogon nardus and Cymbopogon citratus oils showed cytoprotective properties on doxorubicin-induced senescence in the fibroblast-like kidney cell line (Vero) and fibroblasts (NIH/3T3) [88].…”

Section: Cellular Senescencementioning

confidence: 99%

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

Zuzarte,

Sousa,

Alves-Silva

et al. 2024

Biomedicines

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Ageing is a natural process characterized by a time-dependent decline of physiological integrity that compromises functionality and inevitably leads to death. This decline is also quite relevant in major human pathologies, being a primary risk factor in neurodegenerative diseases, metabolic disorders, cardiovascular diseases and musculoskeletal disorders. Bearing this in mind, it is not surprising that research aiming at improving human health during this process has burst in the last decades. Importantly, major hallmarks of the ageing process and phenotype have been identified, this knowledge being quite relevant for future studies towards the identification of putative pharmaceutical targets, enabling the development of preventive/therapeutic strategies to improve health and longevity. In this context, aromatic plants have emerged as a source of potential bioactive volatile molecules, mainly monoterpenes, with many studies referring to their anti-ageing potential. Nevertheless, an integrated review on the current knowledge is lacking, with several research approaches studying isolated ageing hallmarks or referring to an overall anti-ageing effect, without depicting possible mechanisms of action. Herein, we aim to provide an updated systematization of the bioactive potential of volatile monoterpenes on recently proposed ageing hallmarks, and highlight the main mechanisms of action already identified, as well as possible chemical entity–activity relations. By gathering and categorizing the available scattered information, we also aim to identify important research gaps that could help pave the way for future research in the field.

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“…de Carvalho et al [127] found that the essential oil of Eugenia uniflora promoted mitochondrial membrane dysfunction in Drosophila melanogaster by inhibiting oxidative phosphorylation. Similarly, essential oils isolated from several species of Cistus are reported to ameliorate ultraviolet-B-induced mitochondrial damage and cellular senescence in human keratinocytes [128]. Essential oils containing β-caryophyllene as a major constituent in plant species, such as Pterodon emarginatus, Aloysia citrodora, Syzygium aromaticum, Eplingiella fruticosa, Ocimum basilicum, and Salvia rosmarinus, have the potential to counter oxidative stress and mitochondrial dysfunction and have possible links to neuroprotection [129].…”

Section: Msleo Prevents Mitochondrial Membrane Potential (∆ψM) From L...mentioning

confidence: 99%

Mesosphaerum suaveolens Essential Oil Attenuates Inflammatory Response and Oxidative Stress in LPS-Stimulated RAW 264.7 Macrophages by Regulating NF-κB Signaling Pathway

et al. 2023

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Mesosphaerum suaveolens (L.) Kuntze (Syn. Hyptis suaveolens (L.) Poit.) is a wild essential-oil-bearing plant having multiple uses in traditional medicine, perfumery, food, agriculture, and pharmaceutical industries. The present paper is the first report on the in vitro anti-inflammatory effects of the leaf essential oil of M. suaveolens (MSLEO) and unravels its molecular mechanism in LPS-stimulated RAW 264.7 macrophage cells. GC-MS analysis of the essential oil (EO) isolated from the leaves by hydro-distillation led to the identification of 49 constituents, accounting for 90.55% of the total oil, and β-caryophyllene (16.17%), phyllocladene (11.85%), abietatriene (11.46%), and spathulenol (7.89%) were found to be the major components. MSLEO treatment had no effect on the viability of RAW 264.7 cells up to a concentration of 100 μg/mL, and the EO was responsible for a reduction in proinflammatory cytokines like IL-6, IL-1β, and TNF-α, a decrease in intracellular ROS production, and the restoration of oxidative damage by elevating the levels of endogenous antioxidative enzymes like CAT, SOD, GPx, and GSH. RT-qPCR analysis indicated that MSLEO reduced the mRNA expression levels of iNOS and COX-2 as compared to the LPS-induced group. In addition, a confocal microscopy analysis showed that MSLEO inhibited the translocation of NF-κB from the cytosol to the nucleus. The results of this experiment demonstrate that MSLEO possesses significant anti-inflammatory potential by preventing the activation of NF-κB, which, in turn, inhibits the downstream expression of other inflammatory mediators associated with the activation of the NF-κB pathway in LPS-induced RAW 264.7 cells. Thus, the leaf essential oil of M. suaveolens may prove to be a promising therapeutic agent for the treatment of inflammation, and targeting the NF-κB signaling pathway may be considered as an attractive approach for anti-inflammatory therapies.

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Essential Oils Derived from Cistus Species Activate Mitochondria by Inducing SIRT1 Expression in Human Keratinocytes, Leading to Senescence Inhibition

Cited by 6 publications

References 23 publications

Exploring the Anti-Inflammatory and Antioxidant Potential, Metabolite Composition and Inorganic Profile of Cistus monspeliensis L. Aerial Parts and Roots

Exploring the Anti-Inflammatory and Antioxidant Potential, Metabolite Composition and Inorganic Profile of Cistus monspeliensis L. Aerial Parts and Roots

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

Mesosphaerum suaveolens Essential Oil Attenuates Inflammatory Response and Oxidative Stress in LPS-Stimulated RAW 264.7 Macrophages by Regulating NF-κB Signaling Pathway

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