Essential Oils from Ugandan Medicinal Plants: <i>In Vitro</i> Cytotoxicity and Effects on IL‐1<i>β</i>‐Induced Proinflammatory Mediators by Human Gingival Fibroblasts

Ocheng, Francis; Bwanga, Freddie; Boström, Elisabeth A.; Joloba, Moses; Borg‐Karlson, Anna‐Karin; Yucel‐Lindberg, Tülay; Obua, Celestino; Gustafsson, Anders

doi:10.1155/2016/5357689

Cited by 17 publications

(11 citation statements)

References 53 publications

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“…2 Meanwhile, Z. avicennae and Z. chalybeum EOs showed strong cytotoxicity against K-562 cells and human gingival fibroblasts, with IC 50 values of 1.76 µg/mL and 26 µg/mL, respectively. 34,35 In the present study, GC-MS analysis revealed that ZN-L, ZN-F, and ZN-B essential oils contained a variety of phytochemicals, including monoterpenes, sesquiterpenes, hydrocarbons, and nonterpenic acyclic ketones. Furthermore, as discussed earlier, each EO also contained unique bioactive compounds that are present either at a minimal quantity or completely undetected in other EOs.…”

Section: Cytotoxic Activitysupporting

confidence: 51%

Chemical Composition, Antimicrobial, and Cytotoxic Activities of Leaf, Fruit, and Branch Essential Oils Obtained From Zanthoxylum nitidum Grown in Vietnam

Tuyến

Quân

Lê

et al. 2021

Natural Product Communications

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Zanthoxylum nitidum (Roxb.) DC is a traditional Vietnamese medicine to treat coughs, stomachache, toothache, blood stagnation, and sore throats. The essential oils (EOs) of the leaves, fruits, and stems of this plant were extracted by hydrodistillation and subjected to analysis by gas chromatography (GC)-flame ionization detector (FID) and GC-mass spectrometry (MS). The isolated EOs were then evaluated in terms of their antimicrobial activity by minimum inhibitory concentration (MIC) assay and in vitro cytotoxic effect against 5 human tumor cell lines. GC-MS-FID analysis showed 35, 32, and 25 compounds accounting for 97.6%, 91.7%, and 96.2% of the total EO contents from the leaves, fruits, and stems, respectively. The major compounds of the leaf EO were limonene (44.3%), β-caryophyllene (12.5%), linalool (11.0%), germacrene D (5.3%), and α-pinene (4.9%); the major compounds of the fruit EO were n-pentadecane (34.8%), sabinene (18.3%), and n-heptadecane (4.7%), and the major components of the stem EO were 2-undecanone (72.3%), β-caryophyllene (5.8%), and germacrene D (4.0%). The EOs of leaves, fruits, and stems of Z. nitidum exhibited antibacterial activity against Bacillus subtilis, Escherichia coli, and Fusarium oxysporum with MIC values of 100 µg/mL. The leaf and branch EOs exhibited cytotoxic activity against all tested cancer cell lines, especially A-549 and HepG-2. Findings from the present study provide important knowledge about the potential uses of Z. nitidum EOs as a natural antibacterial and antitumor agents.

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Section: Cytotoxic Activitysupporting

confidence: 51%

Chemical Composition, Antimicrobial, and Cytotoxic Activities of Leaf, Fruit, and Branch Essential Oils Obtained From Zanthoxylum nitidum Grown in Vietnam

Tuyến

Quân

Lê

et al. 2021

Natural Product Communications

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“…Skimmianine, furoquinoline alkaloid skimmianine, the benzophenanthridine alkaloids chelerythrine and nitidine, the aporphine alkaloids tembetarine, magnoflorine, N-methylcorydine, N-methylisocorydine (menisperine), and berberine and the phenylethylamine candicine, alkamide, fagaramide, dihydrochelerythrine, lupeol, and sesamin [172] Extracts showed moderate cytotoxicity with IC 50 values below 50 μM against the drug-sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cell lines [172] Stem bark extracts exhibited potential cytotoxicity effect with LC 50 value of 5.74 μg/mL in brine shrimp assay [173] Cytotoxicity reported against human cancer cell line HL-60 cells with IC 50 of 137.31 μg/mL and selectivity index of 3.81 [174]. Cytotoxicity against human gingival fibroblasts cells with IC 50 of 26 ± 3 μg/mL [175] Cytotoxicity of root bark extracts reported with IC 50 of 38.5, 68.9 and < 500 μg/mL in brine shrimp toxicity assay [97,134,176] Evidence-Based Complementary and Alternative Medicine concomitantly in several plants [166], and some studies demonstrated that there is a positive linear relationship between antioxidant activity and anticancer effect of plant extracts [249]. Plant phytochemicals such as artemisinin from the Artemisia genus are reported to have an endoperoxide moiety which is strategic for their bioactivity.…”

Section: Oxalis Corniculatamentioning

confidence: 99%

Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies

Omara

Kiprop

Ramkat

et al. 2020

Evidence-Based Complementary and Alternative Medicine

108

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The burden of neoplastic diseases is a significant global health challenge accounting for thousands of deaths. In Uganda, about 32,617 cancer cases were reported in 2018, accompanied by 21,829 deaths. In a view to identify some potential anticancer plant candidates for possible drug development, the current study was designed to compile the inventory of plants with reported anticancer activity used in rural Uganda and the evidences supporting their use in cancer therapy. An electronic survey in multidisciplinary databases revealed that 29 plant species belonging to 28 genera distributed among 24 families have been reported to be used in the management of cancer in Uganda. Anticancer plants were majorly from the families Bignoniaceae (7%), Caricaceae (7%), Fabaceae (7%), Moraceae (7%), and Rutaceae (7%). Most species occur in the wild (52%), though some are cultivated (48%). The growth habit of the plants is as trees (55%) or herbs (45%). Anticancer extracts are usually prepared from leaves (29%), bark (24%), roots (21%), and fruits (13%) through decoctions (53%), as food spices (23%) or pounded to produce ointments that are applied topically (10%). Prunus africana (Hook.f.) Kalkman, Opuntia species, Albizia coriaria (Welw. ex Oliver), Daucus carota L., Cyperus alatus (Nees) F. Muell., Markhamia lutea (Benth.) K. Schum., and Oxalis corniculata L. were the most frequently encountered species. As per global reports, Allium sativum L., Annona muricata L., Carica papaya L., Moringa oleifera Lam., Opuntia species, Prunus africana (Hook.f.) Kalkman, and Catharanthus roseus (L.) G. Don. are the most studied species, with the latter having vincristine and vinblastine anticancer drugs developed from it. Prostate, cervical, breast, and skin cancers are the top traditionally treated malignancies. There is a need to isolate and evaluate the anticancer potential of the bioactive compounds in the unstudied claimed plants, such as Cyperus alatus (Nees) F. Muell., Ficus dawei Hutch., Ficus natalensis Hochst., and Lovoa trichilioides Harms, and elucidate their mechanism of anticancer activity.

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“…Lemongrass ( Cymbopogon flexuosus ) essential oil (LEO 1 ) has been traditionally used as a remedy for a variety of health conditions. Recent scientific studies have provided evidence supporting its antimicrobial, antioxidant, antifungal, and anti-inflammatory properties in several disease models [1] , [2] , [3] , [4] , [5] , [6] . Boukhatem et al.…”

Section: Introductionmentioning

confidence: 97%

Lemongrass ( Cymbopogon flexuosus ) essential oil demonstrated anti-inflammatory effect in pre-inflamed human dermal fibroblasts

Han¹,

Parker²

2017

Biochimie Open

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Lemongrass (Cymbopogon flexuosus) essential oil (LEO), which has citral as its main component, has exhibited anti-inflammatory effect in both animal and human cells. In this study, we evaluated the anti-inflammatory activity of a commercially available LEO in pre-inflamed human dermal fibroblasts. We first studied the impact of LEO on 17 protein biomarkers that are critically associated with inflammation and tissue remodeling. LEO significantly inhibited production of the inflammatory biomarkers vascular cell adhesion molecule 1 (VCAM-1), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and monokine induced by gamma interferon (MIG); decreased levels of the tissue remodeling biomarkers collagen-I and III, epidermal growth factor receptor (EGFR), and plasminogen activator inhibitor (PAI-1); and inhibited the immunomodulatory biomarker macrophage colony-stimulating factor (M-CSF). Furthermore, we studied the impact of LEO on genome-wide gene expression profiles. LEO significantly modulated global gene expression and robustly impacted signaling pathways, many of which are critical for inflammation and tissue remodeling processes. This study provides the first evidence of the anti-inflammatory activity of LEO in human skin cells and indicates that it is a good therapeutic candidate for treating inflammatory conditions of the skin.

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Essential Oils from Ugandan Medicinal Plants: In Vitro Cytotoxicity and Effects on IL‐1β‐Induced Proinflammatory Mediators by Human Gingival Fibroblasts

Cited by 17 publications

References 53 publications

Chemical Composition, Antimicrobial, and Cytotoxic Activities of Leaf, Fruit, and Branch Essential Oils Obtained From Zanthoxylum nitidum Grown in Vietnam

Chemical Composition, Antimicrobial, and Cytotoxic Activities of Leaf, Fruit, and Branch Essential Oils Obtained From Zanthoxylum nitidum Grown in Vietnam

Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies

Lemongrass ( Cymbopogon flexuosus ) essential oil demonstrated anti-inflammatory effect in pre-inflamed human dermal fibroblasts

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