Essential oils – prospective candidates for antifungal treatment?

Natu, Kalyani N.; Tatke, Pratima

doi:10.1080/10412905.2019.1604437

Cited by 12 publications

(10 citation statements)

References 83 publications

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“…The antimicrobial effect of essential oils against fungal pathogens has been well studied against the test micro-organisms investigated here-in [ 34 , 35 ]. The genus of Cryptococcus is an important cause of opportunistic fungal infection in severely immunocompromised patients with the primary sites of infection including the lungs [ 36 ]. The lowest MIC value determined for the combination of essential oils against C. neoformans was 0.06 mg/mL for 24 combinations including the combination of Citrus limon (lemon) and Santalum austrocaledonicum (sandalwood), which were shown to have broad-spectrum activity.…”

Section: Resultsmentioning

confidence: 99%

Essential Oil Blends: The Potential of Combined Use for Respiratory Tract Infections

2021

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This study investigated the potential efficacy of 369 commercial essential oil combinations for antimicrobial, anti-toxic and anti-inflammatory activity with the aim of identifying synergy among essential oils commonly used in combination by aromatherapists for respiratory purposes. Essential oil combinations were assessed for their antimicrobial activities using a panel of Gram-positive, Gram-negative, and yeast strains associated with respiratory tract infections. The antimicrobial activity was measured by determining the minimal inhibitory concentration (MIC) of microbial growth. The fractional inhibitory concentration index (ΣFIC) was calculated to determine the antimicrobial interactions between the essential oils in the combination. The toxicity of the essential oil combinations was tested in vitro using the brine shrimp lethality assay, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on RAW 264.7 mouse macrophage cells and A549 lung cancer cell lines. In addition, an inflammatory response was evaluated measuring nitric oxide production. The essential oils, when in combination, demonstrated an increased antimicrobial effect, a reduction in toxicity and provided improved anti-inflammatory outcomes. Five distinct combinations [Cupressus sempervirens (cypress) in combination with Melaleuca alternifolia (tea tree), Hyssopus officinalis (hyssop) in combination with Rosmarinus officinalis (rosemary), Origanum marjorana (marjoram) in combination with M. alternifolia, Myrtus communis (myrtle) in combination with M. alternifolia and Origanum vulgare (origanum) in combination with M. alternifolia] were found to be the most promising, demonstrating antimicrobial activity, reduced cytotoxicity and improved anti-inflammatory effects. With the increased prevalence of respiratory tract infections and the growing antimicrobial resistance development associated with antimicrobial treatments, this study provides a promising complementary alternative for the appropriate use of a selection of essential oil combinations for use in the respiratory tract.

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Section: Resultsmentioning

confidence: 99%

Essential Oil Blends: The Potential of Combined Use for Respiratory Tract Infections

2021

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“…According to Natu and Tatke (2019) the aldehydes like citral and cinnamaldehyde, phenolic compounds like thymol, carvacrol, eugenol are abundantly found in some essential oils and show potent antifungal activity. The terpenes have an ability to cross plasma membrane of fungi and interact with enzymes and proteins of the membrane.…”

Section: Evaluation Of the In Vitro Antifungal Activity Of Citral Against The Fungus Aspergillus Brasiliensismentioning

confidence: 99%

Potential use of lemongrass essential oil as fungicide against Aspergillus brasiliensis and as post-harvest protectant of wheat

Lee¹,

Martinazzo

Teodoro

et al. 2021

Acta Sci. Biol. Sci.

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Fungi are among the main responsible for damage and loss in stored grains, its control has been done through synthetic substances, which are harmful to man and the environment. Brazil, one of the leading countries in agriculture, has optimal environmental conditions for the development of mycotoxigenic fungi. Most of the synthetic chemicals used as preservatives have often been realized to be toxic to humans and also cause adverse environmental effects. Thus, it is necessary to search for alternative methods of controlling. In this study the aimed was to evaluate the efficacy of lemongrass essential oil in the control of the Aspergillus brasiliensis. In vitro and serial microdilution tests were carried out at different concentrations of essential oil and citral, which corresponds to 72% of the total oil composition. Inhibition of fungal growth on contaminated wheat grain was evaluated. The in vitro test results showed that the essential oil has fungicidal potential at concentrations from 0.6 μL mL-1, the minimum inhibitory concentration was determined at 0.8 μL mL-1. The tests with citral showed fungal control at concentrations from 0.6 μL mL-1 onwards. For wheat grain, fungal growth inhibition was obtained at the concentration of 1.6 μL mL-1. The essential oil of Cymbopogon flexuosus showed fungicidal activity against the fungus Aspergillus brasiliensis.

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“…Herein however, it can be seen that L. domatiophorus oil displayed higher inhibition against S.aureus with MIC and MLC of 0.25% and 0.5% (v/v) respectively, compared to that of M. alternifolia, C. carvi, P. cablin and P. graveolens oils. According to Mondello et al, M. alternifolia oil inhibited Candida strains with MIC ranging from 0.03% to 0.25% [54]. On the contrary, L. domatiophorus essential oil displayed promising inhibition against Candida species, especially in C. parapsilosis with MIC and MLC values of 0.12% (v/v).…”

Section: Antiviral Activitymentioning

confidence: 99%

In Vitro Antimicrobial Activity of Essential Oil Extracted from Leaves of Leoheo domatiophorus Chaowasku, D.T. Ngo and H.T. Le in Vietnam

Doan

et al. 2020

Plants

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The present study aimed to determine the antimicrobial activity and chemical composition of leaves-extracted essential oil of Leoheo domatiophorus Chaowasku, D.T. Ngo and H.T. Le (L. domatiophorus), including antibacterial, antimycotic, antitrichomonas and antiviral effects. The essential oil was obtained using hydrodistillation, with an average yield of 0.34 ± 0.01% (v/w, dry leaves). There were 52 constituents as identified by GC/MS with available authentic standards, representing 96.74% of the entire leaves oil. The essential oil was comprised of three main components, namely viridiflorene (16.47%), (-)-δ-cadinene (15.58%) and γ-muurolene (8.00%). The oil showed good antimicrobial activities against several species: Gram-positive strains: Staphylococcus aureus (two strains) and Enterococcus faecalis, with Minimum Inhibitory Concentration (MIC) and Minimum Lethal Concentration (MLC) values from 0.25 to 1% (v/v); Gram-negative strains such as Escherichia coli (two strains), Pseudomonas aeruginosa (two strains) and Klebsiella pneumoniae, with MIC and MLC values between 2% and 8% (v/v); and finally Candida species, having MIC and MLC between 0.12 and 4% (v/v).Antitrichomonas activity of the oil was also undertaken, showing IC50, IC90 and MLC values of 0.008%, 0.016% and 0.03% (v/v), respectively, after 48h of incubation. The essential oil resultedin being completely ineffective against tested viruses, ssRNA+ (HIV-1, YFV, BVDV, Sb-1, CV-B4), ssRNA- (hRSVA2, VSV), dsRNA (Reo-1), and dsDNA (HSV-1, VV) viruses with EC50 values over 100 µg/mL. This is the first, yet comprehensive, scientific report about the chemical composition and pharmacological properties of the essential oil in L. domatiophorus.

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Essential oils – prospective candidates for antifungal treatment?

Cited by 12 publications

References 83 publications

Essential Oil Blends: The Potential of Combined Use for Respiratory Tract Infections

Essential Oil Blends: The Potential of Combined Use for Respiratory Tract Infections

Potential use of lemongrass essential oil as fungicide against Aspergillus brasiliensis and as post-harvest protectant of wheat

In Vitro Antimicrobial Activity of Essential Oil Extracted from Leaves of Leoheo domatiophorus Chaowasku, D.T. Ngo and H.T. Le in Vietnam

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