Essential trace elemental levels (zinc, iron and copper) in the biological samples of smoker referent and pulmonary tuberculosis patients

Nizamani, Palwasha; Afridi, Hassan Imran; Kazi, Tasneem Gul; Talpur, Farah Naz; Baig, Jameel Ahmed

doi:10.1016/j.toxrep.2019.11.011

Cited by 17 publications

(10 citation statements)

References 81 publications

(93 reference statements)

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“…The study shows that the copper level higher in TB patients than controls. This finding was matched with (33) who mentioned the level of copper was higher in the biological samples of pulmonary Tuberculosis patients as compared to control (p < .001). This finding also matched with (34) who mentioned that there was a significant increase in serum copper levels of TB patients.…”

Section: Copper Concentrationsupporting

confidence: 80%

Evaluation of some immunological markers related to immune anergy in tuberculosis patients

Israa¹,

Al-Saadi

Hadi

2022

ijhs

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This study was applied on 90 tuberculosis patients admitted in the Babylon Center of Tuberculosis and Chest Diseases in Hilla, Iraq. They were divided into four groups; 50 patients with Pulmonary, 40 patients with Extra pulmonary,20 people as healthy contact group and 20 people as healthy control group. Blood samples were collected from patients and control group to estimate Anti Ascrais lumbricoides-IgG , also Zinc and copper level were also spectrophotometerically estimated. The ages range of all TB cases were ranged from 11 to more than 71 years; TB patients consisted of 51 males and 39 females. The mean of Anti- Ascrais lumbricoides IgG in PTB patient's sera was 0.43±0.17, while in control subjects was 0.20±0.19. The study significantly shows difference between PTB patients and controls, while The mean of anti Ascrais lumbricoides IgG in EPTB patients sera was 0.23±0.02, while in control subjects was0.20±0.19. The study significantly shows no difference between EPTB patients and controls.

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Section: Copper Concentrationsupporting

confidence: 80%

Evaluation of some immunological markers related to immune anergy in tuberculosis patients

Israa¹,

Al-Saadi

Hadi

2022

ijhs

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“…Also, we measurement the levels of albumin and total protein in both groups that were recruited; we found that after 6 months of taking Zn, the albumin concentration was higher and total protein were markedly lower compared to placebo group. Some studies declared possible reasons to the low serum Zn and albumin and total protein in patients with TB infection may be nutritional factors, enteropathy, and acute phase reactant proteins (17)(18)(19). Immune factors such as interleukin-6 and TNF-α are causes to induction of acute phase reactant proteins in the liver, which can lead to decrease of serum albumin also, reason to significant changes in the serum levels of some essential trace elements and total protein (20).…”

Section: Discussionmentioning

confidence: 99%

Investigation of Zinc Supplement Impact on the Serum Biochemical Parameters in Pulmonary Tuberculosis: A Double Blinded Placebo Control Trial

et al. 2021

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Background: Zinc (Zn) is nutritionally essential trace element, and thus deficiency may severely affect human health. The results of cross-sectional studies indicate that micronutrient deficiencies are common in patients with tuberculosis. Our goal is to investigate whether Zn supplementation can increase the effects of anti-TB treatment or not. Methods: Patients with newly diagnosed tuberculosis were divided in to 2 groups. One group (n= 37) received capsule contains 50 mg of elemental zinc (as zinc sulfate) for 6 months every other day (micronutrient group) and Group II (n= 37) received placebo. Both groups received the same anti-tuberculosis treatment recommended by the WHO. Clinical examination, BMI, chest X-ray, direct sputum examination, assessment of serum zinc levels (by atomic absorption spectrophotometry), and biochemical markers serum concentration (by using an RA1000 AutoAnalyzer) were carried out before and after 2-and 6-months anti-tuberculosis treatment. Results: Plasma zinc concentrations in the micronutrient group was higher than placebo group After treatment. In the placebo group increasing in SGOT and SGPT concentrations were significantly higher than micronutrient group after 2 months of treatment (p< 0.05). The significant changes (p< 0.05) were observed on the serum levels of total protein, albumin. Alkaline phosphatase (ALP) levels, serum creatinine, uric acid and urea in groups were not significantly different. Conclusions: Zinc supplementation results in earlier sputum smear conversion in the micronutrient group during the first 6 weeks. Increased body weight and serum zinc and serum albumin and decrease in total protein was observed in the micronutrient group.

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“…For a comprehensive presentation of instrumental conditions and methodological subtleties, we provide detailed data in Supplementary Table S1. In addition, for a holistic understanding of the methods used, we discussed (Nizamani et al 2019; Oan Muhammad Sahito & Rahoojo 2022) in our previous study.…”

Section: Apparatus Reagents and Glasswarementioning

confidence: 99%

Determining the Toxic Elements in Cannabinoid and Opioid Drugs and Their Impact on Addicts' Health

UNAR,

Sahito,

Afridi

2023

Preprint

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Drug addiction is associated with significant health risks, including cardiovascular complications, cancer, and mental disorders. Illicit drugs, such as cannabinoids and opioids, including prescription medications, are widely consumed and have profound health consequences. Understanding the health effects of the toxic elements in these substances is critical for overdose prevention and effective recovery strategies. This study aimed to determine the toxic elements, including arsenic (As), cadmium (Cd), mercury (Hg), and nickel (Ni), in cannabinoid and opioid drugs and in biological samples (blood, scalp hair, and serum) from 311 male drug abuse patients aged 15 to 60 years with a history of drug abuse. The participants were categorized into three age groups. The comparative analysis involved 113 reference subjects of the same age groups. The sample preparation employed microwave-assisted acid digestion, and the toxic elements were quantified using atomic absorption spectrophotometry. Accuracy was ensured using certified reference materials for hair, blood, and serum. Drug-addicted subjects had significantly higher concentrations of toxic elements (arsenic, cadmium, mercury, and nickel) in biological samples than referent subjects (p > 0.001). Elevated levels of these toxic elements may increase susceptibility to infections, possibly due to malnutrition, drug-related effects, and additional contaminants. These findings necessitate further studies to explore the long-term health outcomes, potential treatment options, and broader socioeconomic impacts of substance abuse. This study serves as a baseline for future research in this critical public health field.

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Essential trace elemental levels (zinc, iron and copper) in the biological samples of smoker referent and pulmonary tuberculosis patients

Abstract: Graphical abstract

Cited by 17 publications

References 81 publications

Evaluation of some immunological markers related to immune anergy in tuberculosis patients

Evaluation of some immunological markers related to immune anergy in tuberculosis patients

Investigation of Zinc Supplement Impact on the Serum Biochemical Parameters in Pulmonary Tuberculosis: A Double Blinded Placebo Control Trial

Determining the Toxic Elements in Cannabinoid and Opioid Drugs and Their Impact on Addicts' Health

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