Essential tremor: the most common form of cerebellar degeneration?

Louis, Elan D.; Faust, Phyllis L.

doi:10.1186/s40673-020-00121-1

Cited by 52 publications

(24 citation statements)

References 187 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one study, tandem gait was abnormal in 50% of 36 ET patients as compared to 28% of age-matched controls [ 33 ]. Several studies have provided evidence for a link between ET and cerebellar dysfunction and pathology [ 34 35 36 ]. In our study, subjective imbalance by history was present in 27.3% of all patients, and 23.0% had abnormal tandem gait on examination.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic Features of Isolated Essential Tremor, Essential Tremor Plus, and Essential Tremor-Parkinson’s Disease in a Movement Disorders Clinic

Bellows

Jankovic

2021

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

Background: Patients with essential tremor were initially considered to have isolated tremor, but additional motor and non-motor features have been increasingly recognized. The term "essential tremor plus" was adopted by the Task Force on Tremor of the International Parkinson and Movement Disorder Society to describe essential tremor patients with additional neurologic signs.Objectives: To characterize essential tremor patients and their phenotypes in a movement disorders clinic population in the context of the new tremor classification.Methods: Demographic, clinical, historical, treatment, and diagnostic data were retrospectively collected on 300 patients diagnosed by movement disorder experts with essential tremor. Patients were classified as having essential tremor, essential tremor plus, or essential tremor-Parkinson's disease combination, and features between these groups were compared. Results:Of the 300 patients, 20.7% were classified as isolated essential tremor, 53.3% as essential tremor plus, and 26.0% as essential tremor-Parkinson's disease. There was no significant difference in the duration of tremor symptoms. Essential tremor plus patients were more likely to have dystonia, tandem gait abnormalities, head tremor and greater tremor severity. Essential tremor-Parkinson's disease patients were more likely to have RBD symptoms. There was no significant difference in cognitive impairment between essential tremor plus and essential tremor-Parkinson's disease patients.Conclusions: Additional motor and non-motor features, including parkinsonism, are common in patients with essential tremor. Further studies are needed to clarify essential tremor phenotypes and to provide insights into possible subtypes.Highlights: 300 patients with essential tremor from a movement disorders clinic were re-classified based on the Movement Disorder Society Consensus Statement on the Classification of Tremors. Additional motor and non-motor features, including parkinsonism, were common, and only 20.7% of patients remained classified as isolated essential tremor.

show abstract

Section: Discussionmentioning

confidence: 99%

Phenotypic Features of Isolated Essential Tremor, Essential Tremor Plus, and Essential Tremor-Parkinson’s Disease in a Movement Disorders Clinic

Bellows

Jankovic

2021

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

show abstract

“…In contrast, in ET patients the main pathology might be located within the cerebello-thalamo-cortical loop with a dysfunctional motor controller in the cerebellum [16]. In ET patients, cerebellar pathology has been described [35,36]. Thus it was proposed that the direct generator of both tremor entities might be the cerebello-thalamo-cortical network, however the difference might be the way, this network is activated to oscillate.…”

Section: Discussionmentioning

confidence: 99%

Short-Pulse and Directional Thalamic Deep Brain Stimulation - Differential Effects in Parkinsonian and Essential Tremor

Hidding

Schaper

Gulberti

et al. 2021

Preprint

View full text Add to dashboard Cite

The aim of this study was to assess the effects of novel stimulation algorithms of deep brain stimulation (short pulse and directional stimulation) in the ventrointermediate thalamus and posterior subthalamic area (VIM/PSA-DBS) on tremor in Parkinson´s disease (PD) and to compare the effects with those in Essential tremor (ET). Methods: We recruited six PD patients (70.8±10.4 years) and seven ET patients (64.4±9.9 years) with implanted VIM/PSA-DBS in a stable treatment condition (>3months postoperatively). Tremor severity and ataxia were assessed in four different stimulation conditions in a randomized order: DBS switched off (STIM OFF), omnidirectional stimulation with 60µs (oDBS60), omnidirectional stimulation with 30µs (oDBS30), directional stimulation at the best segment with 60µs (dDBS60)). Results: In both patient groups, all three DBS stimulation modes reduced the total tremor score compared to STIM OFF, whereas stimulation-induced ataxia was reduced by oDBS30 and partially by dDBS60 compared to oDBS60. Tremor reduction was more pronounced in PD than in ET due to a limited DBS effect on intention and action-specific drawing tremor. Conclusion: In PD and ET tremor, the use of short pulse or directional VIM/PSA-DBS is an effective tool to enhance the therapeutic window.The study was registered in the DRKS (ID DRKS00025329, 18.05.2021).

show abstract

“…A few previous works hypothesize that the dopamine depletion in the BG-T-C system may lead to the occurrence of the tremor symptom (Dovzhenok and Rubchinsky, 2012;Helmich et al, 2012;Cagnan et al, 2014). However, recent evidences from clinical, neuroimaging and postmortem studies link essential tremor to cerebellar dysfunction (Louis et al, 2006;Mirdamadi, 2016;Louis, 2018;Louis and Faust, 2020). The authors hypothesize that the cerebellum influenced by dopamine depletion may also contribute to the enhancement of the tremor.…”

Section: Tremor Symptommentioning

confidence: 97%

Neuro4PD: An Initial Neurorobotics Model of Parkinson's Disease

et al. 2021

View full text Add to dashboard Cite

In this work, we present the first steps toward the creation of a new neurorobotics model of Parkinson's Disease (PD) that embeds, for the first time in a real robot, a well-established computational model of PD. PD mostly affects the modulation of movement in humans. The number of people suffering from this neurodegenerative disease is set to double in the next 15 years and there is still no cure. With the new model we were capable to further explore the dynamics of the disease using a humanoid robot. Results show that the embedded model under both conditions, healthy and parkinsonian, was capable of performing a simple behavioural task with different levels of motor disturbance. We believe that this neurorobotics model is a stepping stone to the development of more sophisticated models that could eventually test and inform new PD therapies and help to reduce and replace animals in research.

show abstract

Essential tremor: the most common form of cerebellar degeneration?

Cited by 52 publications

References 187 publications

Phenotypic Features of Isolated Essential Tremor, Essential Tremor Plus, and Essential Tremor-Parkinson’s Disease in a Movement Disorders Clinic

Phenotypic Features of Isolated Essential Tremor, Essential Tremor Plus, and Essential Tremor-Parkinson’s Disease in a Movement Disorders Clinic

Short-Pulse and Directional Thalamic Deep Brain Stimulation - Differential Effects in Parkinsonian and Essential Tremor

Neuro4PD: An Initial Neurorobotics Model of Parkinson's Disease

Contact Info

Product

Resources

About