Established prognostic variables in NO oral carcinoma

Abstract

Tumor thickness is the most important predictor of occult regional metastases in oral cavity cancer.

Primary Tumor Staging for Oral Cancer and a Proposed Modification Incorporating Depth of Invasion

“…This has led to numerous proposed modifications of the staging system based on a variety of clinicopathological factors including DOI, 9,10 which is now well established as an independent predictor of recurrence and survival in oral SCC. [5][6][7][8][9][10][11][12][13][14][15] In the present study, when patients were restaged with a modification of the current AJCC staging system that incorporates DOI, we observed improved discrimination between T categories with respect to both DSS and OS.In agreement with other studies, we found that DOI is an independent predictor of DSS in multivariable analyses. [5][6][7][8][9][10][11][12][13][14][15] Importantly, the association between pathological T cat- egory and DSS remained significant after controlling for DOI, suggesting that they provide complementary information.…”

The Fatty Acid Synthase Inhibitor Orlistat Reduces the Growth and Metastasis of Orthotopic Tongue Oral Squamous Cell Carcinomas

“…Currently, the presence of metastasis in the neck lymph nodes has been considered the most important prognostic factor for OTSCC and responsible for a decrease in the overall survival rates by nearly 50% (6)(7)(8). Of note, 10% to 50% of the patients with OTSCC without clinical evidence of neck lymph node metastasis (N0) may present occult metastatic foci (8)(9)(10). Local recurrences and second primary tumors also negatively impact the prognosis of patients with OTSCC, which usually present significantly worse prognosis than those with squamous cell carcinomas of the oropharynx, larynx, hypopharynx, and other oral cavity sites (11)(12)(13).…”

Conservative Neck Dissection in Oral Cancer Patients: a 5 Year Retrospective Study in Malaysia

“…In different studies, tumor thickness of 3 mm to 5 mm in oral tongue carcinoma,1.5 mm to 3 mm in floor-of-mouth carcinoma, and above 6 mm in buccal mucosa carcinoma were associated with significantly higher rates of occult metastases (Mohit-Tabatabai et al, 1986, Spiro et al, 1986, Fukano et al, 1997, Urist et al, 1987. Clark et al (2006) reported 10% and 46% incidence of regional disease in thin (<5 mm) and thick (>5 mm) tumors, respectively.…”