2019
DOI: 10.1002/jcla.23144
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Establishing a reference range for thromboelastography maximum amplitude in patients administrating with antiplatelet drugs

Abstract: Objective:We aimed to establish the reference range of thromboelastograph (TEG) maximum amplitude (MA) in patients taking antiplatelet drugs. Methods:Between August 2015 and July 2018, a total of 4614 patients administrating with antiplatelet drugs (clopidogrel and aspirin) were retrospectively analyzed in this study. For MA A parameter, we used the 10th and 90th percentiles to establish a reference range. The Spearman correlation was used for the correlation analysis among the inhibition rate of adenosine dip… Show more

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Cited by 6 publications
(5 citation statements)
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“…Both these parameters reflect the strength of the blood clot and depend on platelet count and function and the integrity of the fibrin network (fibrin levels and polymerization, factor XIII). 41,45 High MA and MCF values have been strongly associated with an increased risk of thromboembolic complications in hospitalized patients [46][47][48][49] ; however, these data are derived from non-COVID-19 studies. A clinical consequence of hypercoagulability in severely ill COVID-19 patients may be the frequent occurrence of venous and arterial thrombotic events.…”
Section: Discussionmentioning
confidence: 99%
“…Both these parameters reflect the strength of the blood clot and depend on platelet count and function and the integrity of the fibrin network (fibrin levels and polymerization, factor XIII). 41,45 High MA and MCF values have been strongly associated with an increased risk of thromboembolic complications in hospitalized patients [46][47][48][49] ; however, these data are derived from non-COVID-19 studies. A clinical consequence of hypercoagulability in severely ill COVID-19 patients may be the frequent occurrence of venous and arterial thrombotic events.…”
Section: Discussionmentioning
confidence: 99%
“…The results of hematological examinations indicated that DAPT exerted an insignificant influence on the platelet count (PLT), and the extrinsic and intrinsic coagulation pathways of the enrolled patients. The MA ADP and MA AA values in TEG-PM indicated low platelet function in both groups (reference range: 19.8-43.2 mm for MA ADP , 18.9-37.7 mm for MA AA ) [19].…”
Section: Resultsmentioning
confidence: 85%
“…Pre-extraction TEG TEG technology has been described elsewhere [18,19]. Briefly, TEG was performed using a Thrombelastograph Analyser 5000 (Haemoscope Corp., Niles, IL, USA), standard cups and pins after the collection of venous blood samples in the morning.…”
Section: Patient Enrollmentmentioning
confidence: 99%
“…The calculation of the inhibition rate is more reliable when the MA value is within a reasonable range. 87 …”
Section: The Application Of Teg In Aismentioning
confidence: 99%
“…The calculation of the inhibition rate is more reliable when the MA value is within a reasonable range. 87 In a study evaluating the efficiency of antiplatelet therapy, 202 AIS patients were divided into four groups: aspirin only, clopidogrel only, both aspirin and clopidogrel, and no antiplatelet. In the dual antiplatelet therapy group (mean R = 5.5 min, mean MA = 59.3 mm, mean α-angle = 57.8°), patients tend to have fewer and weaker clots than no antiplatelet therapy (mean R = 4.6 min, mean MA = 64.5 mm, mean angle = 64.5°).…”
Section: Disease Monitoring In Aismentioning
confidence: 99%