Establishing baseline framework for hepatitis B virus micro-elimination in Ho Chi Minh City, Vietnam – a community-based seroprevalence study

Pham, Trang Ngoc Doan; Le, Duc H; Dao, Diem V. B.; Phan, Loc; Pham, Thuy T.; Nguyen, Toan B.; Mize, Gary W.; Gish, Robert G.; Lee, William M.; Trang, Amy; Le, Anh N.; Chen, Moon; Phan, Hai Thanh; Nguyen, Binh Thanh; Tang, Hong; Dao, Doan Y.

doi:10.1016/j.lanwpc.2022.100620

Cited by 3 publications

(5 citation statements)

References 17 publications

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“…However, there are a range of community-based organizations (CBOs) and academic collaborations working in the space which could be more actively engaged in government-led efforts. 12 , 19 , 40 , 41 , 42 , 43 Additionally, experience applying local engagement strategies such as community advisory boards (CABs) within the context of HIV programs 44 , 45 , 46 may also serve as a useful model health system engagement. The involvement of such stakeholders in further strategy or policy development would strengthen governance from a PHC perspective.…”

Section: Discussionmentioning

confidence: 99%

“…Small-scale projects have demonstrated the feasibility of community-based screening led by CBOs and clinics for key populations. 12 , 19 , 40 Challenges remain including ensuring linkage from screening to confirmatory testing and care. One positive development has been the introduction of regulations to allow specimens to be transferred between facilities to enable HCV RNA confirmatory testing and HBV DNA testing for treatment eligibility.…”

Section: Discussionmentioning

confidence: 99%

“…17 , 18 Approximately 9% of Vietnamese adults were found to be positive for HBsAg in a recent seroprevalence survey. 16 Other national estimates of chronic hepatitis B range from 7.5% to 25% 15 , 19 and the most up to date global modeling estimates 6.6% prevalence. 6 There have been no recent national prevalence studies of hepatitis B in the Philippines.…”

Section: Introductionmentioning

confidence: 99%

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Embedding viral hepatitis into primary healthcare: results of a strategic landscape analysis in Vietnam and the Philippines

Holt,

Fernandez,

Nguyen

et al. 2024

The Lancet Regional Health - Western Pacific

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Embedding viral hepatitis into primary healthcare: results of a strategic landscape analysis in Vietnam and the Philippines

Holt,

Fernandez,

Nguyen

et al. 2024

The Lancet Regional Health - Western Pacific

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“…Fortunately, regions lacking the birth dose vaccine represent a critical focus group that can be targeted by microelimination studies. A micro-elimination effort in the capital of Vietnam demonstrated a gap in existing vaccination programs [59]. Pham et al noted that Vietnam had implemented a universal childhood vaccination program since 2003 but found in their study that less than < 20% of the adult population was vaccinated despite 37.7% of adults being susceptible to HBV infection.…”

Section: Nd Pillar: Vaccinationmentioning

confidence: 99%

Evidence-Based Strategies for Micro-elimination of Chronic Hepatitis B Virus Infection

Roma

Hsu

Khattak

et al. 2023

Curr Hepatology Rep

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Purpose of Review Hepatitis B (HBV) remains a health threat around the world. Hepatitis C is closer to meeting the World Health Organization’s 2030 elimination goal compared to HBV. To achieve a successful micro-elimination and macro-elimination, there are certain objectives that need to be met. Recent Findings HBV infects more than 262 million people worldwide and is associated with significant morbidity and increased mortality. There have been previous HBV and hepatitis C virus micro-elimination trials with varying success. Micro-elimination programs should be designed to move services forward with a plethora of avenues for monitoring, testing, and treatment. Summary Ultimately, successful and maintained micro-elimination is needed to achieve macro-elimination of HBV. Here, we propose 5 core tenets of micro-elimination that can be expanded to macro-elimination; these 5-line guidelines provide for 5 pillars of HBV management that support a path to a successful global elimination of HBV.

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“…The Western Paci c region is considered as an intermediate HBV-endemic region by World Health Organization (WHO), with an estimated prevalence of 7.1% (6.3-7.9%) (3). Viet Nam, a lower-middleincome country (LMIC) in the Western Paci c region, has a population of 97 million and an estimated HBV prevalence of 7-8% (4). Since 2018, HBV has been the most common etiology of liver cancer in Viet Nam (5,6).…”

Section: Introductionmentioning

confidence: 99%

Low HBV Knowledge is Associated with Low HBV Vaccination Uptake in General Adult Population Despite Incentivization of HBV Vaccination

Kim,

Pham,

et al. 2023

Preprint

Self Cite

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Background. Hepatitis B virus (HBV) vaccination in Vietnamese adults remains low and unequally distributed. We conducted a study on HBV-naïve adults living in Ho Chi Minh City, Viet Nam, to determine barriers associated with HBV vaccination uptake after removing the financial barrier by providing free coupons for HBV vaccination. Methods. After being screened for HBsAg, anti-HBs, and anti-HBc, 284 HBV-naïve study participants aged 18 and over (i.e., negative for HBsAg, anti-HBs, and anti-HBc total) were distributed with free 3-dose HBV vaccine coupons. Next, study participants’ receipt of 1st, 2nd, and 3rd doses of HBV vaccine was documented at a pre-specified study healthcare facility, where HBV vaccines were distributed at no cost to the participants. Upon study entry, participants answered questionnaires on sociodemographics, knowledge of HBV and HBV vaccination, and related social and behavioral factors. The proportions of three doses of HBV vaccine uptake and their confidence intervals were analyzed. Associations of HBV vaccine initiation with exposures at study entry were evaluated using modified Poisson regression. Results. 98.9% (281 of 284) of study participants had complete data and were included in the analysis. The proportion of obtaining the 1st, 2nd, and 3rd doses of HBV vaccine was 11.7% (95%CI 8.0-15.5%), 10.7% (95%CI 7.1-14.3%), and 8.9% (95%CI 5.6-12.2%), respectively. On the other hand, participants were more likely to initiate the 1st dose if they had adequate knowledge of transmission (adjusted relative risk [aRR] = 2.58, 95% Confidence Interval [95% CI] 1.12-5.92), adequate knowledge of severity (aRR = 6.75, 95%CI 3.38-13.48), and annual health-checking seeking behavior (aRR = 2.04, 95%CI 1.07-3.87). Conclusion. We documented a low HBV vaccination uptake despite incentivization. However, increased vaccine initiation was associated with better HBV knowledge and annual health check-up adherence. When considering expanding HBV vaccination to the general adult population, we should appreciate that HBV knowledge is an independent predictor of vaccine uptake.

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Establishing baseline framework for hepatitis B virus micro-elimination in Ho Chi Minh City, Vietnam – a community-based seroprevalence study

Cited by 3 publications

References 17 publications

Embedding viral hepatitis into primary healthcare: results of a strategic landscape analysis in Vietnam and the Philippines

Embedding viral hepatitis into primary healthcare: results of a strategic landscape analysis in Vietnam and the Philippines

Evidence-Based Strategies for Micro-elimination of Chronic Hepatitis B Virus Infection

Low HBV Knowledge is Associated with Low HBV Vaccination Uptake in General Adult Population Despite Incentivization of HBV Vaccination

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