2021
DOI: 10.1038/s41570-021-00302-4
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Establishing electron diffraction in chemical crystallography

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Cited by 53 publications
(40 citation statements)
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“…A diffraction theory that is more dynamic than the well-known X-ray diffraction is required, and electron crystallography is more complex than kinematic diffraction. Moreover, a specialized detector was used for the experiment, limiting broad adaptability [ 115 ]. Thus far, electron crystallography has only played a minor role in structural chemistry.…”
Section: Discussionmentioning
confidence: 99%
“…A diffraction theory that is more dynamic than the well-known X-ray diffraction is required, and electron crystallography is more complex than kinematic diffraction. Moreover, a specialized detector was used for the experiment, limiting broad adaptability [ 115 ]. Thus far, electron crystallography has only played a minor role in structural chemistry.…”
Section: Discussionmentioning
confidence: 99%
“…Erste Unternehmen produ-Ein sehr lesenswerter, detaillierter Perspektivenartikel über 3D-ED als zu etablierende Methode in der analytischen Chemie ist gerade erschienen und geht auf Gemeinsamkeiten und Unterschiede zur Röntgenbeugung sowie auf praktische Aspekte dieser Methode ein. 89)…”
Section: Elektronendiffraktometrieunclassified
“…11 Excitingly, the emergence of microcrystal electron diffraction (MicroED), a 3D electron diffraction (ED) technique, has allowed for the determination of structures of small molecules and proteins using sub-micrometre-sized crystalline samples. [12][13][14][15][16] Pharmaceutical APIs may readily form crystalline powders suitable for MicroED, simplifying or even eliminating the need to perform crystallization screenings. The MicroED technique has the potential to unlock structural information for thousands of APIs for which growing large crystals is challenging.…”
mentioning
confidence: 99%
“…Unfortunately, unlike X-ray diffraction, ED has not been demonstrated to produce significant anomalous signals, precluding the application of the Flack parameter in the determination of absolute structures from MicroED data. 16 Two methods have emerged for the determination of absolute structures using ED data: using a combination of ED imaging coupled with atomic resolution crystal imaging for inorganic materials 17 , 18 and applying dynamical refinement for small molecules. 19 Unfortunately, collection of atomic resolution imaging mode images is not currently possible for radiation sensitive materials such as pharmaceutical APIs.…”
mentioning
confidence: 99%
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