Establishment and validation of a DNA damage repair gene based model for ovarian cancer typing and prognosis

Abstract

Background Under physiological conditions, DNA damage and repair are in a dynamic equilibrium. When this equilibrium is disrupted, the cell undergoes pathological changes, eventually the cell becomes cancerous. Ovarian cancer (OC) is a malignant disease with unique genomic characteristics, most of the chemotherapeutic agents currently used in ovarian cancer depend on the balance between damage and repair of DNA (DDR). DDR-related genes have potential value as prognostic indicators for ovarian cancer. Results DDR-related genes can well typing ovarian cancer patients, 16 genes associated with prognosis of ovarian cancer patients (CH25H, CCR7, CACNA1C, SLC4A8, CXCL11, UBD, TRPV4, RPS6KA2, FCGBP, TOMM20L, STX18, PI3, CMBL, ISG20, AKAP12, and PIGS) were screened as risk genes for the construction of ovarian cancer prognostic models. Conclusion Based on DDR-related genes for ovarian cancer typing and studying the prognostic relevance of differential genes between typing on ovarian cancer, 16 genes were screened for predicting poor prognosis of OC. To provide research directions for subsequent drug development and research basis for clinical application.