Establishment of reference intervals in Indian population

Ashavaid, Tester F.; Todur, Seema P.; Dherai, Alpa J.

doi:10.1007/bf02867409

Cited by 30 publications

(29 citation statements)

References 7 publications

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“…9), GGT 6.76-51.09, bilirubin 0.40-1.34) as compared to females (SGOT 13-50.43, SGPT 9-63.43, GGT . These findings are consistent to finding of other workers [15][16][17]. These differences can be correlated to dietary habit, smoking and alcoholism.…”

Section: Resultssupporting

confidence: 93%

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Establishment of Reference Interval for Liver Specific Biochemical Parameters in Apparently Healthy North Indian Population

et al. 2012

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Reference intervals (RI) are the most common decision support tool used for interpretation of numerical laboratory reports. The quality of the RI can play as large a role in result interpretation as the quality of the result itself. As such there is hardly any study examining RI for liver specific biochemical parameters in Indian population especially north Indians having drastically different food habits as compared to rest of the India. So there is a need to establish the RI for north Indian population. Present study was conducted on 2,021 apparently healthy individuals of north Indian origin ranging in age from 15-60 years, were selected randomly using defined criteria. Lipemic, hemolysed, icteric and stored samples were also excluded adopting preanalytical criteria for rejection of sample. Non parametric methodology for determination of RI was adopted as most of the biochemical parameters included revealed non Gaussian distribution. Data were analyzed for middle 95 percentile (2.5th-97.5th percentile), median and 95 % confidence interval using SPSS software package version 10.0. The upper and the lower limit of RI (reported Vs observed) for bilirubin (0-1.2 Vs 0.30-1.30 mg/dL), serum glutamate oxaloacetate transferase (SGOT) (0-41 Vs 13-52.80 IU/L), serum glutamate pyruvate transferase (SGPT) (0-50 Vs 10-68 IU/L) showed wide variation as compared to reported standard RI however Gamma glutamyl transferase (GGT) (0-50 Vs 5.00-50.60 IU/L) remained within the reported standard RI. Further gender wise evaluation revealed higher cutoff in males (AST 14-55, ALT 11-70.35, GGT 6.76-51.09 in IU/L, bilirubin (0.40-1.34 mg/dL) as compared to females in IU/L, Bilirubin 0.30-1.20 mg/dL) for both enzymatic and non enzymatic biochemical parameters. The variations may be attributed to dietary pattern smoking and alcoholism.

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Section: Resultssupporting

confidence: 93%

“…12) which showed reverse trend. These findings are consistent to findings observed by other workers [15][16][17]. The increase in RI of SGPT was more pronounced in age group 20-40 years as compared to age groups 41-60 years (Fig.…”

Section: Resultssupporting

confidence: 93%

Establishment of Reference Interval for Liver Specific Biochemical Parameters in Apparently Healthy North Indian Population

et al. 2012

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“…In the present study, RI for these biochemical parameters observed coincided with the reported RI [ Table 1]. In an another study conducted by Ashavaid et al reported lower RI for urea and Creatinine ranging from 4-35mg% and 0.7-1.3mg% respectively in individuals of Mumbai opted for BUPA Health Screening Programme [5]. The lower RI indicates preponderance of vegetarian and young individuals participating in the study.…”

Section: Resultssupporting

confidence: 88%

“…Moreover India is country with extreme seasonal variations, extreme variations in temperature, different dietary habits, life style and physical activity which could affect blood levels of several parameters. There is a need to realize, whether, there is a requirement for restructuring the reference interval for an Indian population [5].…”

Section: Introductionmentioning

confidence: 99%

Reference Interval for Renal Profile parameters in North Indian Population from Rajasthan

Yadav¹,

Gupta²,

Mishra³

et al. 2015

Int J of Adv in Sci Res

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Objective: Reference intervals are an essential part of laboratory medicine. Current study was planned to evaluate renal parameters in the healthy defined group of individuals which would serve as reference values of renal parameters for the North Indian population from Rajasthan. Design & Methods: Present study was conducted on 2021 apparently healthy individuals of North Indian origin ranging in age from 15-60 years, were selected randomly using defined criteria. Fasting samples were analyzed for Urea, Creatinine, Uric Acid, Sodium, Potassium and Chloride. Data were analyzed for middle 95 percentile (2.5th-97.5th percentile), median and 95% confidence interval using SPSS software package version 10.0. Result: RI for Urea, Creatinine and uric acid were lower in female (16-42mg/dl, 0.6-1.2mg/dl, 2.4-6.8mg/dl) as compared to male (17.00-44.35mg/dl, 0.7-1.5mg/dl, 2.8-7.2mg/dl). There was a progressive increase in urea, uric acid and Creatinine with increase in age. Though no appreciable differences could be observed in respect to most of renal parameters in rural versus urban, a wider range for uric acid was observed in urban population (2.50-7.20mg/dl). Except for Na + , K + and Cl -, rest of parameters i.e. urea, creatinine, uric acid were higher range in obese as compared to non obese (17-45 Vs 17-44, 0.66-1.5 Vs 0.60-1.40, 2.5-7.4 Vs 2.5-7.0). Uric acid level was also found to be higher in non vegetarian population (2.6-7.5mg/dl). Conclusion: Findings of this study provide sex, age, BMI, habitat and diet specific renal function reference values to be used for North Indian population.

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“…Our findings are though consistent with studies conducted in south Indian population by Sultana et al and Ashavaid et al to the extent that upper cut off for most of the parameters was higher than the reported RI. However cut off for SGOT, SGPT and GGT in present study was lower as compared to values reported by Sultana et al [2]and Ashavaid et al [3]. The variations in findings may be attributed to differences in size and habitat (rural/urban) of reference population, dietary habits, life style and climatic conditions.…”

Section: Dear Editorcontrasting

confidence: 77%

Reference Intervals of Certain Liver Specific Biochemical Analytes in Indian Population

et al. 2011

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Establishment of reference intervals in Indian population

Cited by 30 publications

References 7 publications

Establishment of Reference Interval for Liver Specific Biochemical Parameters in Apparently Healthy North Indian Population

Establishment of Reference Interval for Liver Specific Biochemical Parameters in Apparently Healthy North Indian Population

Reference Interval for Renal Profile parameters in North Indian Population from Rajasthan

Reference Intervals of Certain Liver Specific Biochemical Analytes in Indian Population

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