Establishment of reference values for selected haematological parameters in young adult Nigerians

Ayemoba, Ojor; Hussain, Nazir; Umar, Tahir; Ajemba-Life, Anthony; Kene, Terfa S.; Edom, Uchechukwu; Ogueri, Ikechukwu; Nwagbara, Goodluck; Ochai, Inalegwu; Eneja, Chikwado

doi:10.1371/journal.pone.0213925

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…We observed that the mean Hb concentration and Hct of the participants were 13.0 g/dl and 40% respectively in our study. This corroborates previous research findings among blood donors [21], but lower than reported by Ayemoba et al [15]. Our study recorded a median total white cell count of 4.9/nl among studied subjects.…”

Section: Discussionsupporting

confidence: 93%

“…The majority (85.4%) of the subjects were between ages18 and 39 years old. The demographic findings in this study were comparable with reports from previous studies among prospective whole blood donors in Nigeria [9] [14] [15]. The predominance of the younger people in the blood donor pool may be explained by the fact that the youth have a better knowledge about blood donation, through being vast in digital technology.…”

Section: Discussionsupporting

confidence: 88%

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Haematology Parameters of Apparently Healthy Prospective Whole Blood Donors in a Nigerian Hospital Setting

Balogun,

Aile,

Nnamani

et al. 2023

OJBD

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Background: Adequate selection of a prospective whole blood donor protects his health and safety of the recipient. Objectives: The main objective of this study was to determine the haematology parameters of apparently healthy prospective whole blood donors. Participants and Methods: This was a hospital based prospective study carried out from August to October 2020 at the blood transfusion unit of the Lagos State University Teaching Hospital (LASUTH), Ikeja, Nigeria. A structured pretested questionnaire was used for data collection. The socio demographic status and the haematology parameters of apparently healthy prospective whole blood donors who tested negative for HIV, hepatitis B and C markers were captured. Obtained data were analysed with the statistical package for the social scientist software version 20. Results: One hundred male (97.1%) and three female (2.9%) apparently healthy prospective whole blood donors were studied. The median age of study subjects was 30 years. Obtained median haematology parameter values were 13 g/dl, 40%, 4.9/nl and 203.9/nl for haemoglobin concentration, haematocrit, total white cell and platelet counts respectively. The median values for the mean corpuscular haemoglobin concentration (MCHC), mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV) of participants were 32.6 g/dl, 27.7 pg and 85.7 fl respectively. Observed prevalence of subnormal haematology parameters for haemoglobin concentration, total white cells, platelets were 12.6%, 25.2%, and 13.6% respectively. Also subnormal values for MCHC, MCH, MCV were 11.7%, 26.2%, and 16.5% respectively among prospective whole blood donors in this study. No higher than normal haematology parameter values were observed. Median values for erythrocyte sedimentation rate was 8.4 mm/hr. Conclusion: A significant

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 88%

Haematology Parameters of Apparently Healthy Prospective Whole Blood Donors in a Nigerian Hospital Setting

Balogun,

Aile,

Nnamani

et al. 2023

OJBD

View full text Add to dashboard Cite

show abstract

“…Korea 2018 [27] Thai 2018 [23] Nigeria 2019 [25] Brazil 2019 [10] Iraq 2020 [13] Iran 2021 [7] Age Canada 2015 [35] Kuwait 2016 [14] Mali 2017 [2] Oman 2018 [3] Kenya 2018 [41] Korea 2018 [27] Thai 2018 [23] Nigeria 2019 [25] Brazil 2019 [10] Iraq 2020 [13] Iran 2021 [7] F menstruation (34). In the current study, the platelet-related findings are consistent with literature (1,27,32,42).…”

Section: [41]mentioning

confidence: 99%

Hematological indices in the adult saudi population: Reference intervals by gender, age, and region

et al. 2022

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IntroductionHematological parameters are critical in disease diagnosis, management, and monitoring; however, complete blood count (CBC) reference intervals vary across populations. The aim of the current study was to provide the reference ranges of hematological parameters/indices in the healthy adult Saudi population.MethodsA multicenter retrospective cross-sectional study was conducted with a sample of employees who were screened pre-employment from January 2015 to December 2019, at tertiary care hospitals in three regions. Demographic and CBC data were extracted from the electronic health system. The 2.5th and 97.5th percentiles were used to determine the reference intervals.ResultsOf a total of 1,388 participants, 53.82% were male. The majority 96% was less than 40 years old, and 85% were from the Central region. Gender-related differences were observed for the RBC count, Hb, HCT, MCV, MCH, MCHC, and the platelet count. Age-related differences were observed for the RBC, Hb, HCT, and eosinophils. The WBC parameters did not differ by gender or age categories. Region-related differences were observed for the RBC, hemoglobin, HCT, MCV, WBC, and basophils. The platelet count was higher in the female group, the age group 40 years and above, and in the Western region. The prevalence of anemia was high in the female group and the Eastern region. The overall neutropenia rate was 12.8%.ConclusionThe data from this study provide hematological parameter reference ranges for the adult Saudi population by gender, age, and region. Gender and age-related differences were observed for the hematological parameters. Anemia was more frequent in the female group and the Eastern region. Caution must be taken when comparing or interpreting results from different age groups, gender, region of origin, and ethnicity.

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“…Studies have equally reported significantly higher values of reticulocyte counts, RBC counts, HGB, and HCT% in adult males compared to the females [ 1 , 2 , 9 , 17 , 20 – 22 ]. B12 deficiency and comorbidities were more common in elderly men [ 23 ], while in a population-based study among healthy Ugandan population, RBC counts, HGB, and HCT% were higher in adult males than females [ 2 ].…”

Section: Resultsmentioning

confidence: 99%

Establishment of Hematological Reference Values among Healthy Adults in Bamenda, North West Region of Cameroon

Nlinwe

Kumenyuy

Funwi

2021

Anemia

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The use of the reference range of values of a laboratory test is highly significant in diagnostic accuracy. However, race and ethnic variations may affect the safe use of reference ranges from a different setting/population. Because the establishment of reference ranges for the Cameroonian population will possibly improve the quality of health care, this study was designed to establish hematological reference ranges among healthy adults in Bamenda, North West region of Cameroon. This was a cross-sectional study carried out within the period of five months from February 2020 to June 2020, at the Bamenda Regional Hospital. A total of 350 (139 females and 211 males) study participants who met the inclusion criteria were included in the study. The Urit 3300 autoanalyzer (Urit Medical Electronic (Group) Co., Ltd, Guilin, China) was used to analyze the hematological parameters. The general health questionnaire for donors, for verification of reference range study and laboratory tests, was used for data collection. Descriptive statistics were used to calculate reference ranges, means, and medians at 95% confidence intervals. Maximum and minimum reference ranges were computed at 97.5th and 2.5th percentiles. The nonparametric test (Mann–Whitney test) was used to determine the significance of the difference in hematological values between the male and female groups. Three (MID%, LYM#, and MID#) out of the 19 hematological parameters were verified, while sixteen (WBC, LYM%, GRAN%, GRAN#, RBC, HGB, HCT%, MCV, MCH, MCHC, RDW_CV, RDW_SD, PLT, MPV, PDW, and PCT%) were established. The currently used reference intervals do not represent the population of the North West region. Therefore, other regional hospitals in Cameroon should establish reference intervals applicable to their respective regions.

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Establishment of reference values for selected haematological parameters in young adult Nigerians

Cited by 6 publications

References 24 publications

Haematology Parameters of Apparently Healthy Prospective Whole Blood Donors in a Nigerian Hospital Setting

Haematology Parameters of Apparently Healthy Prospective Whole Blood Donors in a Nigerian Hospital Setting

Hematological indices in the adult saudi population: Reference intervals by gender, age, and region

Establishment of Hematological Reference Values among Healthy Adults in Bamenda, North West Region of Cameroon

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