Ester-Based Hydrophilic Cyclodextrin Nanosponges for Topical Ocular Drug Delivery

Hayiyana, Zikhona; Choonara, Yahya E.; Makgotloe, Aubrey; Toit, Lisa C. du; Kumar, Pradeep; Pillay, Viness

doi:10.2174/1381612822666161216113207

Cited by 18 publications

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“…The differences in the release patterns show that the migration of the guest molecules and the ability of NSs to entrap the drug molecules depend on the crosslinking between the cyclodextrin monomers. A higher concentration of cross-linker results in hindering of the interaction of MPH and CYT with the cavities of the NSs, thus reducing their effectiveness as a drug carrier [ 53 , 54 ].…”

Section: Resultsmentioning

confidence: 99%

Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan

Salazar

Yutronic

Kogan

et al. 2021

IJMS

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This article describes the synthesis and characterization of β-cyclodextrin-based nano-sponges (NS) inclusion compounds (IC) with the anti-tumor drugs melphalan (MPH) and cytoxan (CYT), and the addition of gold nanoparticles (AuNPs) onto both systems, for the potential release of the drugs by means of laser irradiation. The NS-MPH and NS-CYT inclusion compounds were characterized using scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), energy dispersive spectroscopy (EDS), thermogravimetric analysis (TGA), UV–Vis, and proton nuclear magnetic resonance (1H-NMR). Thus, the inclusion of MPH and CYT inside the cavities of NSs was confirmed. The association of AuNPs with the ICs was confirmed by SEM, EDS, TEM, and UV–Vis. Drug release studies using NSs synthesized with different molar ratios of β-cyclodextrin and diphenylcarbonate (1:4 and 1:8) demonstrated that the ability of NSs to entrap and release the drug molecules depends on the crosslinking between the cyclodextrin monomers. Finally, irradiation assays using a continuous laser of 532 nm showed that photothermal drug release of both MPH and CYT from the cavities of NSs via plasmonic heating of AuNPs is possible.

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Section: Resultsmentioning

confidence: 99%

Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan

Salazar

Yutronic

Kogan

et al. 2021

IJMS

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“…The β-CD:cross-linker molar ratio influence on drug release was investigated. It was found that the β-CD and cross-linker affect the nano-channels produced and, therefore, the extent of hydrogel swelling, drug loading capacity, and the rate of drug release [34,35]. Moreover, to control and design the delivery kinetics, deep knowledge of the cross-linking properties of polymeric structures is a mandatory step [36].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Cross-Linking Density on the Swelling and Rheological Behavior of Ester-Bridged β-Cyclodextrin Nanosponges

et al. 2021

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The cross-linking density influences the physicochemical properties of cyclodextrin-based nanosponges (CD-NSs). Although the effect of the cross-linker type and content on the NSs performance has been investigated, a detailed study of the cross-linking density has never been performed. In this contribution, nine ester-bridged NSs based on β-cyclodextrin (β-CD) and different quantities of pyromellitic dianhydride (PMDA), used as a cross-linking agent in stoichiometric proportions of 2, 3, 4, 5, 6, 7, 8, 9, and 10 moles of PMDA for each mole of CD, were synthesized and characterized in terms of swelling and rheological properties. The results, from the swelling experiments, exploiting Flory–Rehner theory, and rheology, strongly showed a cross-linker content-dependent behavior. The study of cross-linking density allowed to shed light on the efficiency of the synthesis reaction methods. Overall, our study demonstrates that by varying the amount of cross-linking agent, the cross-linked structure of the NSs matrix can be controlled effectively. As PMDA βCD-NSs have emerged over the years as a highly versatile class of materials with potential applications in various fields, this study represents the first step towards a full understanding of the correlation between their structure and properties, which is a key requirement to effectively tune their synthesis reaction in view of any specific future application or industrial scale-up.

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“…Fourier transform infrared spectroscopy in attenuated total reflectance geometry (FTIR-ATR), CHNS/O analysis, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) analysis, light scattering analysis [133], low-frequency Raman scattering [134], high-resolution magic angle spinning (HRMAS) NMR spectroscopy, carbon-13 nuclear magnetic resonance ( 13 C NMR), proton nuclear magnetic resonance ( 1 H NMR), thermogravimetric analysis (TGA), potentiometric titration, Brunauer-Emmett-Teller (BET) analysis, transmission electron microscopy (TEM), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) have been extensively employed in the studies over the years. In addition, the nano-formulations developed need to be evaluated as far as encapsulation efficiency and loading capacity, stability, in vitro drug release, in vivo pharmacokinetic release, efficacy and toxicity are concerned in order to ensure quality and efficacy [35,37,53,56,57,73,76,78,98,109,122,125,[135][136][137][138][139][140].…”

Section: From 2016 To Present: State-of-the-art and Future Prospects Of Nanospongesmentioning

confidence: 99%

“…( 1 H NMR), thermogravimetric analysis (TGA), potentiometric titration, Brunauer-Emmett-Teller (BET) analysis, transmission electron microscopy (TEM), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) have been extensively employed in the studies over the years. In addition, the nano-formulations developed need to be evaluated as far as encapsulation efficiency and loading capacity, stability, in vitro drug release, in vivo pharmacokinetic release, efficacy and toxicity are concerned in order to ensure quality and efficacy [35,37,53,56,57,73,76,78,98,109,122,125,[135][136][137][138][139][140].…”

Section: From 2016 To Present: State-of-the-art and Future Prospects Of Nanospongesmentioning

confidence: 99%

History of Cyclodextrin Nanosponges

et al. 2020

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Nowadays, research in the field of nanotechnology and nanomedicine has become increasingly predominant, focusing on the manipulation and development of materials on a nanometer scale. Polysaccharides have often been used as they are safe, non-toxic, hydrophilic, biodegradable and are low cost. Among them, starch derivatives and, in particular, cyclodextrin-based nanosponges (CD NSs) have recently emerged due to the outstanding properties attributable to their peculiar structure. In fact, alongside the common polysaccharide features, such as the presence of tunable functional groups and their ability to interact with biological tissues, thus giving rise to bioadhesion, which is particularly useful in drug delivery, what makes CD NSs unique is their three-dimensional network made up of crosslinked cyclodextrin units. The name “nanosponge” appeared for the first time in the 1990s due to their nanoporous, sponge-like structure and responded to the need to overcome the limitations of native cyclodextrins (CDs), particularly their water solubility and inability to encapsulate charged and large molecules efficiently. Since CD NSs were introduced, efforts have been made over the years to understand their mechanism of action and their capability to host molecules with low or high molecular weight, charged, hydrophobic or hydrophilic by changing the type of cyclodextrin, crosslinker and degree of crosslinking used. They enabled great advances to be made in various fields such as agroscience, pharmaceutical, biomedical and biotechnological sectors, and NS research is far from reaching its conclusion. This review gives an overview of CD NS research, focusing on the origin and key points of the historical development in the last 50 years, progressing from relatively simple crosslinked networks in the 1960s to today’s multifunctional polymers. The approach adopted in writing the present study consisted in exploring the historical evolution of NSs in order to understand their role today, and imagine their future.

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Ester-Based Hydrophilic Cyclodextrin Nanosponges for Topical Ocular Drug Delivery

Abstract: The ester-based hydrophilic cyclodextrin-based nanosponge derivative can be used as a drug delivery system in topical ocular drug delivery, to improve stability, solubility and corneal permeation.

Cited by 18 publications

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Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan

Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan

Effect of the Cross-Linking Density on the Swelling and Rheological Behavior of Ester-Bridged β-Cyclodextrin Nanosponges

History of Cyclodextrin Nanosponges

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