Esterification process to synthesize isopropyl chloroacetate catalyzed by lanthanum dodecyl sulfate

Abstract

-Isopropyl chloroacetate has been synthesized by esterification of chloroacetic acid and isopropanol, using lanthanum dodecyl sulfate (LDDS) as the catalyst. Various factors that affected the esterification have been investigated, such as reaction time, different water-carrying agent and the amount of catalyst. Under the condition of 1.2/1 molar ratio of isopropanol to chloroacetic acid, 1.0% catalyst (molar percent of chloroacetic acid), 2.5 h reaction time, 5 mL cyclohexane as water-carrying agent and reflux temperature, the esterification conversion of isopropyl chloroacetate reaches 98.3%. The catalytic activity of LDDS is almost equal to that of a Brønsted acid. LDDS, as one kind of water-tolerant Lewis acid, is an excellent catalyst compared to the traditional Lewis acid.

MEASUREMENTS AND THERMODYNAMIC MODELING OF VAPOR-LIQUID EQUILIBRIA FOR BINARY SYSTEMS OF ISOPROPYL CHLOROACETATE WITH CYCLOHEXANE, ISOPROPANOL AND BENZENE AT 101.3 kPa

“…Until now, some works have reported the preparation of isopropyl chloroacetate (Xu et al, 2011;Liu and You, 2012). However, for separation of isopropyl chloroacetate from the reacted solution, the VLE data for the systems of isopropyl chloroacetate + isopropanol, isopropyl chloroacetate + cyclohexane and isopropyl chloroacetate + benzene have not been reported in the NIST database.…”