Estimated glomerular filtration rate and functional status among older people: A systematic review

Corsonello, Andrea; Roller‐Wirnsberger, Regina; Rosa, Mirko Di; Fabbietti, Paolo; Wirnsberger, Gerhard; Kostka, Tomasz; Guligowska, Agnieszka; Tap, Lisanne; Mattace-Raso, Francesco; Gil, Pedro; Guardado-Fuentes, Lara; Meltzer, Itshak; Yehoshua, Ilan; Artzi-Medevdik, Rada; Formiga, Francesç; Moreno-González, Rafael; Weingart, Christian; Freiberger, Ellen; Ärnlöv, Johan; Carlsson, Axel C.; Lattanzio, Fabrizia

doi:10.1016/j.ejim.2018.05.030

Cited by 21 publications

(24 citation statements)

References 65 publications

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Section: Methodsmentioning

confidence: 99%

“…Kidney function was measured, according to estimated glomerular filtration rate (eGFR) category, based on the GFR BIS equation, which is among the few equations specifically developed and validated among people aged 70 or more [31,32]: 3736 Â creatinine -0:87 Â age -0:95 Â0:82 if female ½ Participants were divided into 4 groups presenting stages of CKD: G1-2 (60 or more); G3A (45-59.9); G3B (30-44.9); G4 (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), and were also dichotomized as CKD(−) group (GFR ≥ 60) and CKD(+) group (GRF < 60) [33].…”

Section: Kidney Functionmentioning

confidence: 99%

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Association between kidney function, nutritional status and anthropometric measures in older people

Lattanzio

Corsonello

Bustacchini³

et al. 2020

BMC Geriatr

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Background Different mechanisms connect the nutritional status with the occurrence and the course of chronic kidney disease (CKD). The end-stage renal disease is complicated by catabolic inflammatory reactions and cachexia which leads to malnutrition (undernutrition). On the other hand, obesity is an important risk factor for the development and acceleration of CKD. Methods In the SCOPE study, community-dwelling persons aged 75 years and over, from 6 European countries and Israel were examined at the baseline phase. We assessed the relationship between anthropometric measures (Body Mass Index (BMI), circumferences of arm (AC), waist (WC), hip (HC), and calf (CC), waist-to-hip ratio - WHR, waist-to-height ratio - WHtR, risk of malnutrition (Mini Nutritional Assessment - MNA), serum albumin) and estimated glomerular filtration rate (eGFR) calculated by Berlin Initiative Study (BIS) equation. Results We studied 2151 subjects (932 men and 1219 women) with a mean age of 79.5 ± 5.9 years. A total of 1333 (62%) participants had CKD (GRF < 60 ml/min/1.73 m2). Negative correlations between eGFR and weight, AC, WC, HC, CC, BMI, WHtR were observed. Positive correlation occurred between eGFR and MNA score (Spearman’s rho = 0.11) and albumin concentration (rho = 0.09). Higher weight, AC, WC, HC, CC, BMI and WHtR increased the odds ratio of CKD; higher MNA (OR = 0.98, 95% CI 0.94–1.0) and higher serum albumin (OR = 0.73, 95% CI 0.53–1.0) were weakly associated with reduced odds. The risk of malnutrition was the highest with eGFR < 30 as compared to eGFR > 60 (OR = 2.95, 95%CI = 1.77–4.94 for MNA < 24; OR = 5.54, 95%CI = 1.66–18.5 for hypoalbuminemia < 3.5 g/dL). Conclusion The population of community dwelling people aged 75+ with CKD shows general features of overweight and obesity with a small prevalence of malnutrition. For anthropometric measures, the strongest association with eGFR and the highest odds of CKD were identified using WC, HC, CC and WHtR. Albumin level and MNA, but not MNA Short Form, indicated an increased odds of malnutrition with a decrease in eGFR.

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Section: Methodsmentioning

confidence: 99%

Section: Kidney Functionmentioning

confidence: 99%

Association between kidney function, nutritional status and anthropometric measures in older people

Lattanzio

Corsonello

Bustacchini³

et al. 2020

BMC Geriatr

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“…Frailty can be present even in the absence of chronic conditions, suggesting that there are different pathways leading to its development (71). Evidence showing how multimorbidity can lead to frailty is still lacking (72,73) and more research on this is needed. The prevalence of both conditions increases with age, even if they do not affect only older persons (40,74).…”

Section: Frailty and Multimorbiditymentioning

confidence: 99%

The Importance of Taking a Patient-Centered, Community-Based Approach to Preventing and Managing Frailty: A Public Health Perspective

Adja

Lenzi

Sezgin

et al. 2020

Front. Public Health

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“…The SCOPE project (screening for chronic kidney disease among older people across Europe, grant agreement number 634869) was funded under the umbrella of the Horizon 2020 program of the European Commission (EC) in 2015. The project involves nine partners across Europe and Israel and aims at developing new standards in diagnostics and treatment of older citizens at risk for chronic kidney disease (CKD), as screening programs in Europe are highly heterogeneous, fragmented and in most cases based on opportunistic rather than structured assessments of patients [20,21]. During the SCOPE project, the impact of an innovative comprehensive screening methodology specifically targeting CKD among older people across Europe is addressed.…”

Section: The Project "Screening For Chronic Kidney Disease Among Oldementioning

confidence: 99%

Massive open online courses (MOOCs) for long-distance education in geriatric medicine across Europe

Roller‐Wirnsberger

Zitta²,

Herzog

et al. 2019

Eur Geriatr Med

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The aim of the paper is to give insight into MOOCs in general and to specifically describe a MOOC developed in the course of the SCOPE project "Screening for Chronic Kidney Disease (CKD) among older People across Europe". Findings The major target of the MOOC was the improvement of knowledge for a broad audience. The SCOPE MOOCs are freely accessible, structured in three modules, offer additional learning material and guarantee knowledge dissemination about aging and chronic kidney diseases. Message The MOOCs represent a contemporary example of how modern technology is supporting a transition to modern training in geriatrics.

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Estimated glomerular filtration rate and functional status among older people: A systematic review

Abstract: Available data do not support the superiority of one of the eGFR equations in terms of measuring or predicting functional decline.

Cited by 21 publications

References 65 publications

Association between kidney function, nutritional status and anthropometric measures in older people

Association between kidney function, nutritional status and anthropometric measures in older people

The Importance of Taking a Patient-Centered, Community-Based Approach to Preventing and Managing Frailty: A Public Health Perspective

Massive open online courses (MOOCs) for long-distance education in geriatric medicine across Europe

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