Estimating Cyclic Shear Strain in the Common Carotid Artery Using Radiofrequency Ultrasound

Idzenga, Tim; Holewijn, Suzanne; Hansen, Hendrik H.G.; Korte, Chris L. de

doi:10.1016/j.ultrasmedbio.2012.07.022

Cited by 35 publications

(33 citation statements)

References 28 publications

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“…Second, we did not confirm whether principal strains would allow better plaque delineation (Majdouline et al, 2014a). It could also prove useful to assess how anisotropy varies during atherosclerotic plaque development (Idzenga et al, 2012). Clinicians could potentially use this information to either reverse or slow down the atherosclerotic process (Meaney et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Principal Strain Vascular Elastography: Simulation and Preliminary Clinical Evaluation

Nayak

Huntzicker

Ohayon

et al. 2017

Ultrasound in Medicine & Biology

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It is difficult to produce reliable polar strain elastograms (radial and circumferential) because the center of carotid artery is typically unknown. Principal strain imaging can overcome this limitation, but suboptimal lateral displacement estimates measured with conventional ultrasonic imaging methods make this an impractical approach for visualizing the mechanical properties within the carotid artery. We hypothesize that compounded plane wave imaging can minimize this problem. To corroborate this hypothesis, we performed (a) simulations with vessels of varying morphology and mechanical behavior (i.e., isotropic and transversely isotropic), and (b) a pilot study with 10 healthy volunteers. The accuracy of principal and polar strain (computed using knowledge of the precise vessel center) elastograms varied between 7–17%. In both types of elastograms, strain concentrated at the junction between the fibrous cap and the vessel wall, and the strain magnitude decreased with increasing fibrous cap thickness. Elastograms obtained from healthy volunteers were consistent with those obtained from transversely isotropic homogeneous vessels; they were spatially asymmetric–a trend that was common to both principal and polar strains. No significant differences were observed in the mean strain recovered from principal and polar strains (p > 0.05). This investigation demonstrates that principal strain elastograms measured with compounding plane wave imaging overcame problems incurred when polar strain elastograms are computed with imprecise estimates of the vessel center.

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Section: Discussionmentioning

confidence: 99%

Principal Strain Vascular Elastography: Simulation and Preliminary Clinical Evaluation

Nayak

Huntzicker

Ohayon

et al. 2017

Ultrasound in Medicine & Biology

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“…We have, however, shown that in both large predominantly elastic arteries and in large muscular arteries there is a distinct bi-directional displacement of the arterial wall during the cardiac cycle [18]. The intima-media of these arteries exhibits a longitudinal displacement that is larger than that of the adventitial region [18] and thus, there is shear strain and shear stress within the arterial wall [18][19][20][21]. We have recently reported that longitudinal movement and intramural shear strain undergo profound changes in response to the important circulatory hormones adrenalin and noradrenalin [22], indicating that the longitudinal movements and resulting intramural shear strain can constitute an important but overlooked mechanism in the cardiovascular system.…”

Section: Introductionmentioning

confidence: 98%

Iterative 2D Tissue Motion Tracking in Ultrafast Ultrasound Imaging

et al. 2018

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Abstract:In order to study longitudinal movement and intramural shearing of the arterial wall with a Lagrangian viewpoint using ultrafast ultrasound imaging, a new tracking scheme is required. We propose the use of an iterative tracking scheme based on temporary down-sampling of the frame-rate, anteroposterior tracking, and unbiased block-matching using two kernels per position estimate. The tracking scheme was evaluated on phantom B-mode cine loops and considered both velocity and displacement for a range of down-sampling factors (k = 1-128) at the start of the iterations. The cine loops had a frame rate of 1300-1500 Hz and were beamformed using delay-and-sum. The evaluation on phantom showed that both the mean estimation errors and the standard deviations decreased with an increasing initial down-sampling factor, while they increased with an increased velocity or larger pitch. A limited in vivo study shows that the major pattern of movement corresponds well with state-of-the-art low frame rate motion estimates, indicating that the proposed tracking scheme could enable the study of longitudinal movement of the intima-media complex using ultrafast ultrasound imaging, and is one step towards estimating the propagation velocity of the longitudinal movement of the arterial wall.

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“…There are fewer studies of noninvasive carotid plaque imaging using elastography, and strain imaging (Maurice et al 2004; Maurice et al 2005; Ribbers et al 2007; Schmitt et al 2007; Shi and Varghese 2007; Maurice et al 2008; Shi et al 2008a; Hansen et al 2009; Hansen et al 2010; McCormick et al 2011; Idzenga et al 2012; McCormick et al 2012). Maurice et al (2004) proposed a Von Mises parameter to characterize vessel wall and utilized a Lagrangian speckle model estimator to calculate the strain tensor in order to estimate axial, lateral, shear and radial strain in the plaque.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Cognitive Function with Ultrasound Strain Indices in Carotid Plaque

Wang

Jackson

Varghese

et al. 2014

Ultrasound in Medicine & Biology

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Instability in carotid vulnerable plaque can generate cerebral microemboli, that may be related to both stroke and eventual cognitive abnormality. Strain imaging to detect plaque vulnerability based on regions with large strain fluctuations, with arterial pulsation, may be able to determine risk of cognitive impairment. Plaque instability may be characterized by increased strain variations over a cardiac cycle. Radiofrequency signals for ultrasound strain imaging were acquired from the carotid arteries of 24 human subjects using a Siemens Antares with a VFX 13-5 linear array transducer. These patients underwent standardized cognitive assessment (Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)). Plaque regions were segmented by a radiologist at end-diastole using the Medical Imaging Interaction Toolkit. A hierarchical block-matching motion tracking algorithm was utilized to estimate the cumulated axial, lateral, and shear strains within the imaging plane. The maximum, minimum and peak-to-peak strain indices in the plaque computed from the mean cumulated strain over a small region of interest in the plaque with large deformations, were obtained. The maximum and peak-to-peak mean cumulated strain indices over the entire plaque region were also computed. All the strain indices were then correlated with RBANS Total performance. Overall cognitive performance (RBANS Total) was negatively associated with values of the maximum strain and the peak-to-peak for axial and lateral strains respectively. There was no significant correlation between the RBANS Total score and shear strain, and strain indices averaged over the entire identified plaque for this group of patients. However, correlation of the maximum lateral strain was higher for symptomatic patients (r=−0.650, p=0.006) than that for asymptomatic patients (r=−0.115, p=0.803). On the other hand correlation for maximum axial strain averaged over the entire plaque region was significantly higher for asymptomatic patients (r=−0.817, p=0.016) than that for symptomatic patients (r=−0.224, p=0.402). The results reveal a direct relationship between the maximum axial and lateral strain indices in carotid plaque with cognitive impairment.

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Estimating Cyclic Shear Strain in the Common Carotid Artery Using Radiofrequency Ultrasound

Cited by 35 publications

References 28 publications

Principal Strain Vascular Elastography: Simulation and Preliminary Clinical Evaluation

Principal Strain Vascular Elastography: Simulation and Preliminary Clinical Evaluation

Iterative 2D Tissue Motion Tracking in Ultrafast Ultrasound Imaging

Correlation of Cognitive Function with Ultrasound Strain Indices in Carotid Plaque

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