Estimating GFR in children with ^99mTc‐DTPA renography: a comparison with single‐sample ⁵¹Cr‐EDTA clearance

Abstract

Glomerular filtration rate (GFR) measurement by (51)Cr-ethylenediaminetetraacetic acid (EDTA) and blood sampling in children is usually cumbersome for the patient, parents and laboratory technicians. We have previously developed a method accurately estimating GFR in adults. The aim of the present study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from (99m)Tc-diethylene triamine pentaacetic acid (DTPA) renography and compared with (51)Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4.7 years). The correlation between (99m)Tc-DTPA renography and (51)Cr-EDTA plasma clearance was for all children R = 0.96 (n = 29, P<0.0001), for children above 2 years of age R = 0.96 (n = 18, P<0.0001) and for children <2 years R = 0.84 (n = 11, P<0.001). We conclude that assessment of GFR from (99m)Tc-DTPA renography is reliable and comparable to GFR calculated from (51)Cr-EDTA plasma clearance. Because our method is non-invasive and only takes 21 min, it may be preferable in many cases where an assessment of renal function is needed in children especially when renography is performed anyhow.

Effect of hydroxyurea treatment on renal function parameters: Results from the multi‐center placebo‐controlled BABY HUG clinical trial for infants with sickle cell anemia

“…Although the norms reported in the literature are for 51 Cr-EDTA-GFR, the correlation between 99m Tc-DTPA and 51 Cr-EDTA plasma clearances is excellent. DTPA may give slightly higher values than EDTA (<5% difference), but this difference is not clinically significant [21, 33]. …”

Pediatric Renal Ontogeny and Applications in Drug Development

“…The correlation between 99m Tc‐DTPA renography and 51 Cr‐EDTA plasma CL was for all children R = 0.96 (n = 29; P < .0001), for children >2 years of age R = 0.96 (n = 18; P < .0001) and for children <2 years R = 0.84 (n = 11; P < .001). The authors concluded that the assessment of GFR from 99m Tc‐DTPA renography is reliable and comparable to GFR calculated from 51 Cr‐EDTA plasma CL and, given that it is less invasive, may be preferable in the pediatric population …”

“…The authors concluded that the assessment of GFR from 99m Tc-DTPA renography is reliable and comparable to GFR calculated from 51 Cr-EDTA plasma CL and, given that it is less invasive, may be preferable in the pediatric population. 34…”

Assessment of the CKD-EPI Equation to Estimate Glomerular Filtration Rate in Adults from a Chinese CKD Population

“…24 The patients in the present study represented all five stages of renal disease, according to K/DOQI guidelines 12 and, because 59% of them were in CKD stages 1 -2 and had raised GFR levels, the GFR was underestimated by all four equations. This underestimation was consistent with previous reports for the MDRD equations.…”