Estimating the motor unit number of the flexor carpi ulnaris muscle with <scp>MScanFit MUNE</scp>

Alaydın, Halil Can; Turkmen, Nur; Boran, H. Evren; Çengiz, Bülent

doi:10.1002/mus.27650

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…based on MScanFit-1 analysis [7,22,30]. Our findings are consistent with the notion that CMAP maximum alone is not a reliable indicator of the number of motor units in a muscle [31].…”

Section: Plos Onesupporting

confidence: 88%

Estimation of the number of motor units in the human extensor digitorum brevis using MScanFit

Klein,

Liu,

Xiong

2024

PLoS ONE

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Objective Our aim was to determine the number and size parameters of EDB motor units in healthy young adults using MScanFit, a novel approach to motor unit number estimation (MUNE). Since variability in MUNE is related to compound muscle action potential (CMAP) size, we employed a procedure to document the optimal EDB electromyographic (EMG) electrode position prior to recording MUNE, a neglected practice in MUNE. Methods Subjects were 21 adults 21–44 y. Maximum CMAPs were recorded from 9 sites in a 4 cm2 region centered over the EDB and the site with the largest amplitude was used in the MUNE experiment. For MUNE, the peroneal nerve was stimulated at the fibular head to produce a detailed EDB stimulus-response curve or “MScan”. Motor unit number and size parameters underlying the MScan were simulated using the MScanFit mathematical model. Results In 19 persons, the optimal recording site was superior, superior and proximal, or superior and distal to the EDB mid-belly, whereas in 3 persons it was proximal to the mid-belly. Ranges of key MScanFit parameters were as follows: maximum CMAP amplitude (3.1–8.5 mV), mean SMUP amplitude (34.4–106.7 μV), mean normalized SMUP amplitude (%CMAP max, 0.95–2.3%), largest SMUP amplitude (82.7–348 μV), and MUNE (43–103). MUNE was not related to maximum CMAP amplitude (R2 = 0.09), but was related to mean SMUP amplitude (R2 = -0.19, P = 0.05). Conclusion The EDB CMAP was highly sensitive to electrode position, and the optimal position differed between subjects. Individual differences in EDB MUNE were not related to CMAP amplitude. Inter-subject variability of EDB MUNE (coefficient of variation) was much less than previously reported, possibly explained by better optimization of the EMG electrode and the unique approach of MScanFit MUNE.

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“…based on MScanFit-1 analysis [7,22,30]. Our findings are consistent with the notion that CMAP maximum alone is not a reliable indicator of the number of motor units in a muscle [31].…”

Section: Plos Onesupporting

confidence: 88%

Estimation of the number of motor units in the human extensor digitorum brevis using MScanFit

Klein,

Liu,

Xiong

2024

PLoS ONE

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Reliability of MScanFit Motor Unit Number Estimation in the Trapezius Muscle

Sørensen,

Tankisi

2024

Muscle and Nerve

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Introduction/AimsMScanFit motor unit number estimation (MUNE) is the most recent MUNE method which has shown promising results in extremity muscles, but it has not been applied to bulbar muscles. Bulbar muscles are particularly important in the diagnosis of amyotrophic lateral sclerosis (ALS). This study aimed to investigate the feasibility and reliability of MScanFit MUNE in the accessory nerve and trapezius muscles.MethodsA total of twenty healthy participants were examined twice within 1–2 weeks. We extracted the MScanFit MUNE and size parameter, and compound muscle action potential (CMAP) amplitude values. The reliability of these parameters was assessed using the intra‐rater coefficient of variation (CoV), intraclass correlation coefficient (ICC), and Bland–Altman plots. We also correlated MUNE values with CMAP amplitudes using correlation coefficients.ResultsMean MUNE values (Day 1 = 132.1 and Day 2 = 137.4), CMAP amplitudes (Day 1 = 9.71 mV and Day 2 = 10.10 mV) and size parameters did not differ between the two sessions (p > 0.05). CoV showed excellent reliability for MUNE values, size parameters, and CMAP amplitudes (CoV < 7%) whereas ICCs showed moderate reliability for MUNE values (ICC = 0.619), poor to moderate reliability for size parameters (between 0.393 and 0.689), and good reliability for CMAP amplitude (ICC = 0.864) There was no correlation between MUNE values and CMAP amplitudes.DiscussionMScanFit MUNE is applicable and mostly reliable in the trapezius muscle. Further studies in patients are needed to investigate the sensitivity of MScanFit in this muscle in detecting motor unit loss, particularly in ALS.

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Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres

Sørensen,

Bostock,

Abrahao

et al. 2023

Clinical Neurophysiology

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Estimating the motor unit number of the flexor carpi ulnaris muscle with MScanFit MUNE

Cited by 4 publications

References 15 publications

Estimation of the number of motor units in the human extensor digitorum brevis using MScanFit

Estimation of the number of motor units in the human extensor digitorum brevis using MScanFit

Reliability of MScanFit Motor Unit Number Estimation in the Trapezius Muscle

Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres

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