Estimating the total economic costs of Neospora caninum infections in dairy cows in Turkey

Demir, Pınar; Eşki, Funda; Ütük, Armağan Erdem

doi:10.1007/s11250-020-02351-1

Cited by 14 publications

(10 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…N. caninum is a major causative agent of abortion and stillbirths in cattle [2]. Neosporosis is prevalent worldwide [1] and inflicts high economic losses to dairy cattle systems [3,4], which have been estimated above one billion US dollars per annum [5]. A recent meta-analysis study estimated that the highest prevalence of bovine neosporosis occurs in North, Central and South America, followed by Asia, Europe, and Oceania [6].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect against Neosporosis Induced by Intranasal Immunization with Neospora caninum Membrane Antigens Plus Carbomer-Based Adjuvant

et al. 2022

View full text Add to dashboard Cite

Neospora caninum is an obligate intracellular protozoan responsible for abortion and stillbirths in cattle. We previously developed a mucosal vaccination approach using N. caninum membrane proteins and CpG adjuvant that conferred long-term protection against neosporosis in mice. Here, we have extended this approach by alternatively using the carbomer-based adjuvant Carbigen™ in the immunizing preparation. Immunized mice presented higher proportions and numbers of memory CD4+ and CD8+ T cells. Stimulation of spleen, lungs and liver leukocytes with parasite antigens induced a marked production of IFN-γ and IL-17A and, less markedly, IL-4. This balanced response was also evident in that both parasite-specific IgG1 and IgG2c were raised by immunization, together with specific intestinal IgA. Upon intraperitoneal infection with N. caninum, immunized mice presented lower parasitic burdens than sham-immunized controls. In the infected immunized mice, memory CD4+ T cells predominantly expressed T-bet and RORγt, and CD8+ T cells expressing T-bet were found increased. While spleen, lungs and liver leukocytes of both immunized and sham-immunized infected animals produced high amounts of IFN-γ, only the cells from immunized mice responded with high IL-17A production. Since in cattle both IFN-γ and IL-17A have been associated with protective mechanisms against N. caninum infection, the elicited cytokine profile obtained using CarbigenTM as adjuvant indicates that it could be worth exploring for bovine neosporosis vaccination.

show abstract

Section: Introductionmentioning

confidence: 99%

Protective Effect against Neosporosis Induced by Intranasal Immunization with Neospora caninum Membrane Antigens Plus Carbomer-Based Adjuvant

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Neosporosis is of signi cant economic importance in livestock, particularly cattle, in which infection is characterised by abortions, stillbirths, the birth of weak neonates, congenital malformation, increased numbers of culled cows and decreased milk yield (Kierbić et al, 2019;Gharekhani et al, 2020), with associated annual losses running into hundreds of millions of United States dollars (Reichel et al, 2013;Demir et al, 2020). Infection in these intermediate hosts is through ingestion of food and water contaminated with sporulated oocyst (Dubey et al, 2007;McAllister, 2020), with the subsequent vertical transmission in infected herds playing a more signi cant role (Sinnott et al, 2017;Gharekhani et al, 2020;Lefkaditis et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and associated risk factors of Neospora caninum in cattle in the Khomas region of Namibia

Samkange

Chitanga

Tjipura-Zaire

et al. 2022

Preprint

View full text Add to dashboard Cite

Neospora caninum is a coccidian parasite which occurs worldwide and is one of the most important causes of abortion, especially in cattle. However, no studies have been done in Namibia to determine the N. caninum status in livestock. Therefore, this study aimed to determine the seroprevalence level of N. caninum in cattle and the associated risk factors in the Khomas region of Namibia. Seven hundred thirty-six (736) serum samples were collected from female cattle in 32 farming establishments. These comprised 698 beef and 38 dairy cattle sera and were tested using a commercial IDEXX Neospora X2® ELISA kit. Questionnaires were concurrently administered to determine possible risk factors associated with N. caninum seropositivity. A total of 42 sera were positive (all beef), giving an animal-level seroprevalence rate of 5.7%. Eight of the 32 establishments had at least one positive animal, giving a herd-level seroprevalence of 25%. There was no significant association between seropositivity and the presence of dogs, jackals, history of abortions, farm size, number of cattle or average annual rainfall. The establishments with moderate to high numbers of Feliformia were 9.8 times more likely to be seropositive to N. caninum than those with none to low levels of the former (p = 0.0245). The authors concluded that the seroprevalence level of N. caninum in the Khomas region was relatively low compared to other parts of the world and that the role of Feliformia in the epidemiology of bovine neosporosis needed to be further investigated.

show abstract

“…Neosporosis causes significant economic losses both at the level of individual livestock farms and in the entire livestock industry due to the deterioration of reproduction indicators, reduced productivity and the costs associated with preventive measures [24][25][26]. This disease is difficult to control since there is no specific treatment and affordable and efficacious vaccine prevention.…”

Section: Introductionmentioning

confidence: 99%

Pathohistological changes in aborted foetuses of cows due to neosporosis: Evidence from Ukraine

Nyzhnyk¹,

Hrushkovska²,

Kataieva³

et al. 2022

Ukrainian journal of veterinary sciences

View full text Add to dashboard Cite

Neosporosis is a parasitic disease characterized by abortions and the birth of weak offspring in cows. The causative agent of Neospora caninum is an obligate, protozoan parasite that belongs to the type Apicomplexa. The relevance of the study is conditioned upon the adverse impact of neosporosis on the economy of Ukraine (loss of productivity, veterinary and diagnostic costs). Furthermore, the issue of neosporosis is understudied. In this regard, the purpose of this study was to establish pathohistological changes in aborted foetuses and the foetal part of placentas and to confirm the involvement of the parasite (Neospora caninum) in cases of abortions recorded in different regions of the country. Two methods were used to investigate this problem: histological and real-time polymerase chain reaction. In aborted foetuses positive for N. caninum, the following pathohistological changes were most often detected: focal gliosis and perivascular mononuclear infiltrates in the brain; focal or diffuse mononuclear infiltration in the heart and skeletal muscles; periportal mononuclear infiltrates in the liver; focal necrosis of the mucous membrane and mononuclear infiltration in the foetal part of the placenta. Changes were less often detected in the lungs – mononuclear infiltration of the interstitium and diffuse lymphocytic alveolitis, and in the kidneys – diffuse interstitial mononuclear infiltration. No changes were found in the spleen. Neospore-like cysts were found in one out of twelve foetuses. Lesions established of foetal organs and placentas are inherent in neosporosis. The results of histological studies substantially complement the data of other authors, confirm the involvement of N. caninum in the occurrence of abortions in cows in certain regions of Ukraine, and also represent practical value for the diagnosis and control of neosporosis in cattle

show abstract

Estimating the total economic costs of Neospora caninum infections in dairy cows in Turkey

Cited by 14 publications

References 25 publications

Protective Effect against Neosporosis Induced by Intranasal Immunization with Neospora caninum Membrane Antigens Plus Carbomer-Based Adjuvant

Protective Effect against Neosporosis Induced by Intranasal Immunization with Neospora caninum Membrane Antigens Plus Carbomer-Based Adjuvant

Seroprevalence and associated risk factors of Neospora caninum in cattle in the Khomas region of Namibia

Pathohistological changes in aborted foetuses of cows due to neosporosis: Evidence from Ukraine

Contact Info

Product

Resources

About