Estimation of 24-Hour Polyamine Intake From Mature Human Milk

Dorhout, Bernard; Vanbeusekom, Cm; Huisman, Martijn; Kingma, Aw; deHoog, E; Boersma, E. R.; Muskiet, Frits A. J.

doi:10.1097/00005176-199610000-00015

Cited by 34 publications

(33 citation statements)

References 18 publications

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“…Several studies have been published evaluating the polyamine concentrations in human milk, but reported results were highly different because of the different methodologies; milk collection, storage and analysis; and high interindividual variability. All the previous studies support the conclusion that putrescine is less abundant in human milk comparing with spermidine and spermine, and our study agrees with earlier reports by Romain et al [5] , Dorhout et al [27] , and Atiya Ali et al [3] . Regarding spermidine and spermine in human milk, several reports show more heterogenic data.…”

Section: Milk Polyamines Compositionsupporting

confidence: 93%

“…Our results for spermidine were similar to those reported by Romain et al [5] , Dorhout et al [27] , and Atiya Ali et al [3] ; and higher than those reported by Buts et al [4] and Pollack et al [28] . For spermine, our results are similar to those reported by Romain et al [5] and higher than those reported by Buts et al [4] , Pollack et al [28] , Dorhout et al [27] , and Atiya Ali et al [3] . Therefore, common methodologies are required to assess and compare the concentrations of polyamines in human milk.…”

Section: Milk Polyamines Compositionsupporting

confidence: 92%

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Breast Milk Polyamines and Microbiota Interactions: Impact of Mode of Delivery and Geographical Location

et al. 2017

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Background/Aims: The aim of the present study was to identify and quantify the polyamine levels in human milk obtained from different countries and through different modes of delivery, and to investigate their association with breast milk microbes. Methods: Mature breast milk samples were obtained from 78 healthy mothers after 1 month of lactation from 4 different geographical locations: Finland, Spain (Europe); South Africa (Africa); and China (Asia). Polyamines were determined using HPLC after dansyl derivatization and milk microbiota was obtained by 16S rRNA gene sequencing. Results: The mean values of polyamines in breast milk were 70.0, 424.2, and 610.0 nmol/dL for putrescine, spermidine and spermine, respectively, and 1,170.9 nmol/dL of total polyamines. The levels of putrescine were significantly higher in Spain (p < 0.05) and spermidine levels were significantly higher in Finland (p < 0.05) compared with other countries. Cesarean delivery had an impact on polyamine levels and it was related to an increase in the putrescine concentration being significant in Spanish samples (p < 0.01). Furthermore, putrescine levels were correlated positively with Gammaproteobacteria (r = 0.46, p < 0.001), especially with Pseudomonas fragi (r = 0.40, p < 0.001). Conclusions: The results demonstrate significant effect of geographical variations in human milk polyamine concentrations, being correlated with human milk microbiota composition. These differences may have an impact on infant development during lactation.

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Section: Milk Polyamines Compositionsupporting

confidence: 93%

Section: Milk Polyamines Compositionsupporting

confidence: 92%

Breast Milk Polyamines and Microbiota Interactions: Impact of Mode of Delivery and Geographical Location

et al. 2017

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“…() and Dorhout et al . (), being 77 and 129 nmol dL −1 , respectively. This variation in putrescine levels may be a result of dietary variability and methodology, although genetic differences cannot be excluded (Romain et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Polyamine levels in breast milk are associated with mothers' dietary intake and are higher in preterm than full‐term human milk and formulas

Ali

Strandvik

Sabel

et al. 2013

J Human Nutrition Diet

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“…In the present study, all mothers provided samples of hind milk. In another study that analysed breast milk with a relatively low fat content, indicating that it was not hind milk, the putrescine and spermidine concentrations were similar to those shown in the present study (Dorhout et al ., ). This might suggest that the polyamine concentration is not influenced by the emptying phase of the breast.…”

Section: Discussionmentioning

confidence: 99%

Lower polyamine levels in breast milk of obese mothers compared to mothers with normal body weight

Ali

Strandvik

Palme-Kilander

et al. 2013

J Human Nutrition Diet

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Background Obesity is associated with risks for mother and infant, and the mothers' dietary habits influence breast milk composition. Polyamines are secreted in breast milk and are essential for the regulation of intestinal and immune function in newborns and infants. The present study aimed to investigate the level of polyamines in human milk obtained from obese and normal weight mothers at different times of lactation. Methods Breast milk from 50 mothers was obtained at day 3, and at 1 and 2 months after delivery. The mothers had normal body weight [body mass index (BMI) < 25 kg m–2] or were obese (BMI > 30 kg/m2). A subgroup of obese mothers participated in a weight reduction programme during pregnancy. Polyamines were analysed using high‐performance liquid chromatography. Results The total polyamine content was significantly lower at all times in breast milk from obese mothers compared to milk from controls. Spermine levels did not differ between groups at any time in contrast to the levels of putrescine and spermidine. Putrescine concentrations were highest on day 3 and spermidine and spermine were highest at 1 month of lactation. The obese mothers, who received dietary advice during pregnancy based on the Nordic Nutrition Recommendations, had higher concentrations of putrescine and spermidine in their milk than the obese mothers without any intervention. Conclusions Polyamine concentrations were lower in breast milk from obese mothers compared to mothers with a normal weight. General dietary intervention in obese mothers increased the polyamine levels, suggesting that the low levels in obesity were at least partly associated with food habits. However, the consistency of spermine suggests a special metabolic function of this polyamine.

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Estimation of 24-Hour Polyamine Intake From Mature Human Milk

Cited by 34 publications

References 18 publications

Breast Milk Polyamines and Microbiota Interactions: Impact of Mode of Delivery and Geographical Location

Breast Milk Polyamines and Microbiota Interactions: Impact of Mode of Delivery and Geographical Location

Polyamine levels in breast milk are associated with mothers' dietary intake and are higher in preterm than full‐term human milk and formulas

Lower polyamine levels in breast milk of obese mothers compared to mothers with normal body weight

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