Estimation of myocardial flow reserve utilizing an ultrafast cardiac SPECT: Comparison with coronary angiography, fractional flow reserve, and the SYNTAX score

The potential of regional myocardial blood flow measurement with SPECT

“…Of interest, these flow parameters better predicted the presence of impaired FFR compared to conventional semi-quantitative perfusion parameters derived from relative perfusion images. These results support those of Miyagawa et al 15 who showed a significant correlation (r = 0.62) between FFR and regional CFR index in a larger population.…”

“…While some studies use extraction fraction parameters of other tracers such as ammonia to calculate index of MBF, 8 others rely on ratios of K1 values avoiding extraction fraction correction. 15 SPECT MBF measurements with extraction fraction correction correlate well with PET measurements using a 1-tissue-compartment model 12 and a retention model, 9 suggesting that this approach with extraction fraction correction is optimal. Multicenter studies assessing the diagnostic performance and the prognostic utility of SPECT MBF are also necessary to determine its incremental value relative to relative perfusion imaging.…”

Modern scintigraphic methods for assessing myocardial blood flow and reserve

“…В исследовании M. Miyagawa и соавт. [55], которое посвящено оценке состояния коронарной гемодинамики у пациентов с многососудистым поражением коронарных артерий, выявлено наличие статистически значимых взаимосвязей сцинтиграфического показателя РКК со значением фракции выброса левого желудочка, ФРК и величиной SYNTAX Score. Чувствительность и специфичность динамической ОФЭКТ в идентификации многососудистого поражения коронарных артерий при выборе пограничного значения РКК = 1,3 составили 93,3 и 75,9% соответственно.…”

Clinical usefulness of quantification of myocardial blood flow and flow reserve using CZT-SPECT for detecting coronary artery disease in patients with normal stress perfusion imaging

“…Dedicated ultra-fast cardiac cameras using cadmium zinc telluride (CZT) have greatly improved sensitivity and they do not require to be rotated around the patient. The detectors facilitate tomographic dynamic acquisition and offer the theoretical possibility of investigating radiotracer kinetics in vivo [3,[16][17][18]. However, there is no published report that evaluates the detection of balanced ischemia due to multi-vessel CAD limited to patients with normal stress MPS, that is, summed stress score (SSS)…”