2021
DOI: 10.48550/arxiv.2105.06853
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Estimation of Parameters for an Archetypal Model of Cardiomyocyte Membrane Potentials

Abstract: Contemporary realistic mathematical models of single-cell cardiac electrical excitation are immensely detailed. Model complexity leads to parameter uncertainty, high computational cost and barriers to mechanistic understanding. There is a need for reduced models that are conceptually and mathematically simple but physiologically accurate. To this end, we consider an archetypal model of single-cell cardiac excitation that replicates the phase-space geometry of detailed cardiac models, but at the same time has a… Show more

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